morpholinobenzyl formamide | 22027-75-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: morpholinobenzyl formamide
• 英文别名: MBF；N-(morpholin-4-yl-phenyl-methyl)-formamide；N-[morpholin-4-yl(phenyl)methyl]formamide
• CAS: 22027-75-4
• 化学式: C₁₂H₁₆N₂O₂
• 分子量: 220.271
• InChiKey: OEWHIZXNHWGCEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  morpholinobenzyl formamide 在 sodium carbonate 、 三氯氧磷 作用下， 生成 α-morpholinobenzyl isocyanide
  参考文献：
  名称：

  Synthesis of α-Amino Isocyanides and α-Alkylthio Isocyanides

  摘要：

  通过脱水 N-(δ-吗啉苄基)甲酰胺和 N-[1-(烷硫基)烷基]甲酰胺，以良好的收率合成了δ-吗啉苄基异氰酸酯和三种 1-(芳基[或烷基]硫基)烷基异氰酸酯，它们本身是由 1-(1-甲酰氨基烷基)苯并三唑与吗啉或硫醇一起制备的。

  DOI：

  10.1055/s-1993-25788
• 作为产物：
  描述：

  吗啉 、 1-(α-formylaminobenzyl)benzotriazole 在 potassium carbonate 作用下， 以 甲醇 为溶剂， 反应 12.0h， 以62%的产率得到morpholinobenzyl formamide
  参考文献：
  名称：

  Synthesis of α-Amino Isocyanides and α-Alkylthio Isocyanides

  摘要：

  通过脱水 N-(δ-吗啉苄基)甲酰胺和 N-[1-(烷硫基)烷基]甲酰胺，以良好的收率合成了δ-吗啉苄基异氰酸酯和三种 1-(芳基[或烷基]硫基)烷基异氰酸酯，它们本身是由 1-(1-甲酰氨基烷基)苯并三唑与吗啉或硫醇一起制备的。

  DOI：

  10.1055/s-1993-25788

文献信息

• Monoacylaminals by the Benzotriazole-Assisted Aminoalkylation of Amides
  作者：Alan R. Katritzky

  DOI：10.1055/s-1998-2164

  日期：1998.10
• Sekiya,M.; Sakai,H., Chemical and pharmaceutical bulletin, 1969, vol. 17, # 1, p. 32 - 35
  作者：Sekiya,M.、Sakai,H.

  DOI：——

  日期：——
• Peroxo complexes of uranium(VI) containing nitrogen and oxygen donor ligands
  作者：Balgar Singh、Simpy Mahajan、H. N. Sheikh、Mohita Sharma、Bansi Lal Kalsotra

  DOI：10.1134/s003602361208013x

  日期：2012.8

  The uranium(VI) peroxo complexes containing Mannich base ligands having composition [UO(O-2)L-L(NO3)(2)] where L-L = morpholinobenzyl acetamide (MBA), piperidinobenzyl acetamide (PBA), morpholinobenzyl benzamide (MBB), piperidinobenzyl benzamide (PBB), morpholinomethyl benzamide (MMB), piperidinomethyl benzamide (PMB), morpholinobenzyl formamide (MBF)}, piperidinobenzyl formamide (PBF) are reported. In a typical reaction UO2(NO3)(2) center dot 6H(2)O (1 mmol, 0.502 g) was dissolved in methanol. An equimolar (1 mmol) methanolic solution (30 mL) of the ligand (Mannich bases) was added to a solution of uranyl nitrate followed by addition of potassium hydroxide (KOH) (2 mmol, 0.1122 g). The solution was refluxed for 15 min and then 10 mL of 30% hydrogen peroxide (H2O2) was added dropwise and was refluxed for an additional 1 h. The synthesized complexes have been characterized by various physico-chemical techniques, viz. elemental analysis, molar conductivity, magnetic susceptibility measurements, infra red, electronic, mass spectral and TGA/DTA studies. These studies revealed that the synthesized complexes are non-electrolytic and diamagnetic in nature. The ligands are bound to metal in a bidentate mode through carbonyl oxygen and the ring nitrogen. Thermal analysis result provides conclusive evidence for the absence of water molecule in the complexes. Mass spectra confirm the molecular mass of the complexes. Antibacterial activity of complexes revealed enhanced activity of complexes as compared to corresponding free ligands. Molecular modeling suggests pentagonal bipyramidal structure for complexes.
• A Convenient Synthesis of N-(α-Aminobenzyl)formamides
  作者：Purabi Devi、A. J. Boulton

  DOI：10.1080/00397919508015428

  日期：1995.6

  Three-component condensation of benzaldehyde, formamide, and morpholine or piperidine, results in an expeditious synthesis of the N-(alpha-dialkylaminobenzyl)-formamides.
• Katritzky Alan R., Xie Linghong, Fan Wei-Qiang, Synthesis, (1993) N 1, S 45-47
  作者：Katritzky Alan R., Xie Linghong, Fan Wei-Qiang

  DOI：——

  日期：——

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