2-methoxybenzyl 3-<(3,4-dimethoxyphenethyl)amino>-2-hydroxypropionate | 83230-64-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-methoxybenzyl 3-<(3,4-dimethoxyphenethyl)amino>-2-hydroxypropionate
• 英文别名: 2-Methoxybenzyl 3-[[N-(3,4-Dimethoxyphenethyl)]amino]-2-hydroxypropionate；(2-methoxyphenyl)methyl 3-[2-(3,4-dimethoxyphenyl)ethylamino]-2-hydroxypropanoate
• CAS: 83230-64-2
• 化学式: C₂₁H₂₇NO₆
• 分子量: 389.448
• InChiKey: HEHJBYCDODCLFB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  28
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  86.2
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  3,4-二甲氧基苯乙胺 在 盐酸 作用下， 以 苯 为溶剂， 反应 21.0h， 生成 2-methoxybenzyl 3-<(3,4-dimethoxyphenethyl)amino>-2-hydroxypropionate
  参考文献：
  名称：

  [(Arylcarbonyl)oxy]propanolamines. 1. Novel .beta.-blockers with ultrashort duration of action

  摘要：

  Novel [(arylcarbonyl)oxy]propanolamines were synthesized and investigated as potential ultrashort-acting beta-adrenergic receptor blockers. Many of these analogues exhibited good potency and short duration. The N-ureidoalkyl analogue 85 (ACC-9089) has a potency equal to propranolol and a duration of action of about 21 min in the dog. It has been selected as a candidate for further clinical study. Structure-activity relationships and structure-duration relationships for these new beta-blockers are also discussed.

  DOI：

  10.1021/jm00374a013

文献信息

• Method for treatment or prophylaxis of cardiac disorders
  申请人：American Hospital Supply Corporation

  公开号：US04405642A1

  公开（公告）日：1983-09-20

  A method for the treatment or prophylaxis of cardiac disorders in a mammal, comprising administering to such mammal a short-acting .beta.-blocking compound of the formula: ##STR1## wherein X is an ester-containing group; R may be lower alkyl, aralkyl or an ester-containing group; R.sub.1 may be lower alkyl; and Ar may be substituted or unsubstituted aromatic; or a pharmaceutically acceptable salt thereof. Novel compounds possessing short acting .beta.-adrenergic blocking activity are also disclosed.

  一种治疗或预防哺乳动物心脏疾病的方法，包括向该哺乳动物投与公式为：##STR1##其中X是酯基含有的基团；R可以是较低烷基，芳基烷基或酯基含有的基团；R.sub.1可以是较低烷基；Ar可以是取代或未取代的芳香基；或其药学上可接受的盐。还揭示了具有短效β-肾上腺素能阻滞活性的新化合物。
• Compounds for treatment or prophylaxis of cardiac disorders
  申请人：American Hospital Supply Corporation

  公开号：US04604481A1

  公开（公告）日：1986-08-05

  A method for the treatment or prophylaxis of cardiac disorders in a mammal, comprising administering to such mammal a short-acting .beta.-blocking compound of the formula: ##STR1## wherein X is an ester-containing group; R may be lower alkyl, aralkyl or an ester-containing group; R.sub.1 may be lower alkyl; and Ar may be substituted or unsubstituted aromatic; or a pharmaceutically acceptable salt thereof. Novel compounds possessing short acting .beta.-adrenergic blocking activity are also disclosed.

  一种治疗或预防哺乳动物心脏疾病的方法，包括向该哺乳动物投与式为：##STR1## 其中X为酯基含有的基团；R可以是较低的烷基、芳基烷基或酯基含有的基团；R.sub.1可以是较低的烷基；Ar可以是取代或未取代的芳香族基；或其药学上可接受的盐。还披露了具有短效β-肾上腺素能阻滞活性的新化合物。
• METHOD FOR TREATMENT OR PROPHYLAXIS OF CARDIAC DISORDERS
  申请人：AMERICAN HOSPITAL SUPPLY CORPORATION

  公开号：EP0065964A1

  公开（公告）日：1982-12-08
• EP0065964A4
  申请人：——

  公开号：EP0065964A4

  公开（公告）日：1983-04-06
• US4405642A
  申请人：——

  公开号：US4405642A

  公开（公告）日：1983-09-20