1,5,6,7-Tetrahydro-2-methyl-1-tosyl-4H-indol-4one | 95526-50-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,5,6,7-Tetrahydro-2-methyl-1-tosyl-4H-indol-4one
• 英文别名: 2-Methyl-4-oxo-1-tosyl-4,5,6,7-tetrahydroindole；2-methyl-1-(4-methylphenyl)sulfonyl-6,7-dihydro-5H-indol-4-one
• CAS: 95526-50-4
• 化学式: C₁₆H₁₇NO₃S
• 分子量: 303.382
• InChiKey: YPSNFSLHLMPFQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  64.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,5,6,7-Tetrahydro-2-methyl-1-tosyl-4H-indol-4one 、 氮甲基苯胺三氟乙酸 生成 2-Methyl-5-methylidene-1-(4-methylphenyl)sulfonyl-6,7-dihydroindol-4-one
  参考文献：
  名称：

  LE, TOURNEAU MICHAEL E.;MCCARTHY, JAMES R.;TREPANIER, DONALD L.

  摘要：

  DOI：
• 作为产物：
  描述：

  2-甲基-4,5,6,7-四氢-1H-吲哚-4-酮 在 四丁基溴化铵 、 对甲苯磺酰氯 作用下， 以 四氢呋喃 、 NaOH 、 水 、 乙腈 为溶剂， 反应 1.0h， 以97%的产率得到1,5,6,7-Tetrahydro-2-methyl-1-tosyl-4H-indol-4one
  参考文献：
  名称：

  EP1367050

  摘要：

  公开号：

文献信息

• 2-methylindole-4-acetic acid, process for producing the same, and process for producing intermediate therefor
  申请人：——

  公开号：US20040092750A1

  公开（公告）日：2004-05-13

  2-Methylindole-4-acetic acid, which is represented by the formula (I) and is an intermediate for an important indole derivative as medicines; and a process for producing the compound and the synthetic intermediates. The process for producing 2-methylindole-4-acetic acid and synthetic intermediates is described in this invention. As shown in formula (I), 2-methylindole-4-acetic acid is an intermediate of important indole derivative which is useful tools for medicine. 1 According to the process described in this invention, 2-methylindole-4-acetic acid, which is an intermediate of important indole derivative as medicines, can be produced in high yield using inexpensive reagents under mild conditions which are suitable for industrial production.

  2-甲基吲哚-4-乙酸，化学式表示为（I），是一种重要的吲哚衍生物药物中间体；本发明提供了一种制备该化合物和合成中间体的方法。本发明描述了制备2-甲基吲哚-4-乙酸和合成中间体的方法。如化学式（I）所示，2-甲基吲哚-4-乙酸是重要的吲哚衍生物的中间体，是药物研究中有用的工具。根据本发明所述的方法，可以在适宜于工业生产的温和条件下，使用廉价试剂高产地制备2-甲基吲哚-4-乙酸，该化合物是重要的吲哚衍生物药物中间体。
• Novel aryloxycycloalkanolaminoalkylene aryl ketones
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0127143A2

  公开（公告）日：1984-12-05

  This invention relates to aryloxycycloalkanolaminoalkylene aryl ketones to the processes for their preparation and to their use as antihypertensive agents.

  本发明涉及芳氧基环烷醇氨基亚烷基芳基酮及其制备工艺和作为降压药的用途。
• 2-METHYLINDOLE-4-ACETIC ACID, PROCESS FOR PRODUCING THE SAME, AND PROCESS FOR PRODUCING INTERMEDIATE THEREFOR
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1367050A1

  公开（公告）日：2003-12-03

  2-Methylindole-4-acetic acid, which is represented by the formula (I) and is an intermediate for an important indole derivative as medicines; and a process for producing the compound and the synthetic intermediates. The process for producing 2-methylindole-4-acetic acid and synthetic intermediates is described in this invention. As shown in formula (I), 2-methylindole-4-acetic acid is an intermediate of important indole derivative which is useful tools for medicine. According to the process described in this invention, 2-methylindole-4-acetic acid, which is an intermediate of important indole derivative as medicines, can be produced in high yield using inexpensive reagents under mild conditions which are suitable for industrial production.

  2-甲基吲哚-4-乙酸，由式（I）表示，是一种重要的药物吲哚衍生物的中间体；以及生产该化合物和合成中间体的工艺。 本发明描述了生产 2-甲基吲哚-4-乙酸和合成中间体的工艺。如式（I）所示，2-甲基吲哚-4-乙酸是重要吲哚衍生物的中间体，是有用的医药工具。 根据本发明所述工艺，可在温和的条件下使用廉价试剂高产制得 2-甲基吲哚-4-乙酸，而 2-甲基吲哚-4-乙酸是重要的吲哚衍生物中间体，适合工业化生产。
• LETOURNEAU, MICHAEL E.;MCCARTHY, JAMES R.;TREPANIER, DONALD L.
  作者：LETOURNEAU, MICHAEL E.、MCCARTHY, JAMES R.、TREPANIER, DONALD L.

  DOI：——

  日期：——
• EP0127143B1
  申请人：——

  公开号：EP0127143B1

  公开（公告）日：1990-03-21