3,5-dimaleimidobenzoic acid N-hydroxysuccinimide ester | 105039-62-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,5-dimaleimidobenzoic acid N-hydroxysuccinimide ester
• 英文别名: (2,5-Dioxopyrrolidin-1-yl) 3,5-bis(2,5-dioxopyrrol-1-yl)benzoate
• CAS: 105039-62-1
• 化学式: C₁₉H₁₁N₃O₈
• 分子量: 409.312
• InChiKey: XQKWMVCLKMJNNJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  138
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  、 3,5-dimaleimidobenzoic acid N-hydroxysuccinimide ester 在 硫代异氰酸苯酯 作用下， 以 乙腈 为溶剂， 以91%的产率得到
  参考文献：
  名称：

  Functionalized Keggin- and Dawson-type cyclopentadienyltitanium heteropolytungstate anions: small, individually distinguishable labels for conventional transmission electron microscopy. 2. Reactions

  摘要：

  DOI：

  10.1021/ja00285a013
• 作为产物：
  描述：

  3,5-二氨基苯甲酸 在 sodium hydroxide 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 1.0h， 生成 3,5-dimaleimidobenzoic acid N-hydroxysuccinimide ester
  参考文献：
  名称：

  Functionalized Keggin- and Dawson-type cyclopentadienyltitanium heteropolytungstate anions: small, individually distinguishable labels for conventional transmission electron microscopy. 2. Reactions

  摘要：

  DOI：

  10.1021/ja00285a013

文献信息

• KEANA J. F. W.; OGAN M. D.; LU YIXIN; BEER M.; VARKEY J., J. AMER. CHEM. SOC., 108,(1986) N 25, 11-13
  作者：KEANA J. F. W.、 OGAN M. D.、 LU YIXIN、 BEER M.、 VARKEY J.

  DOI：——

  日期：——
• DETECTION OF ANTIBODY THAT BINDS TO WATER SOLUBLE POLYMER-MODIFIED POLYPEPTIDES
  申请人：Lubich Christian

  公开号：US20110070592A1

  公开（公告）日：2011-03-24

  The present invention provides analytical methods for detecting anti-polymer antibody in an individual. The methods involve contacting a sample from the individual with a water soluble polymer-modified carrier and detecting binding of antibody to the water soluble polymer on the water soluble polymer-modified carrier wherein binding is indicative of the presence of antibody to the water polymer-modified polypeptide. Antibody may be detected to water soluble polymers such as polyethylene glycol, polysialic acid, dextran, hydroxyalkyl starch, or hydroxyethyl starch. When antibody to the water soluble polymer polyethylene glycol is to be detected, the carrier is modified with a non-linear polyethylene glycol derivative.
• US8216793B2
  申请人：——

  公开号：US8216793B2

  公开（公告）日：2012-07-10
• [EN] DETECTION OF ANTIBODY THAT BINDS TO WATER SOLUBLE POLYMER-MODIFIED POLYPEPTIDES<br/>[FR] DÉTECTION D'ANTICORPS LIANT DES POLYPEPTIDES MODIFIÉS PAR DES POLYMÈRES HYDROSOLUBLES
  申请人：BAXTER INT

  公开号：WO2010138474A1

  公开（公告）日：2010-12-02

  The present invention provides analytical methods for detecting anti- polymer antibody in an individual. The methods involve contacting a sample from the individual with a water soluble polymer-modified carrier and detecting binding of antibody to the water soluble polymer on the water soluble polymer-modified carrier wherein binding is indicative of the presence of antibody to the water polymer-modified polypeptide. Antibody may be detected to water soluble polymers such as polyethylene glycol, polysialic acid, dextran, hydroxyalkyl starch, or hydroxyethyl starch. When antibody to the water soluble polymer polyethylene glycol is to be detected, the carrier is modified with a non-linear polyethylene glycol derivative.
• Functionalized Keggin- and Dawson-type cyclopentadienyltitanium heteropolytungstate anions: small, individually distinguishable labels for conventional transmission electron microscopy. 2. Reactions
  作者：John F. W. Keana、Marc D. Ogan、Yixin. Lu、Michael. Beer、J. Varkey

  DOI：10.1021/ja00285a013

  日期：1986.12