N-[8-(bis(allyloxycarbonylmethyl)amino)-3,6-dioxaoctyl]-(2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9-hexadecafluoro-10-(pyren-1-ylmethoxy)decyloxy)acetamide | 917232-18-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 芘
• 英文名称: N-[8-(bis(allyloxycarbonylmethyl)amino)-3,6-dioxaoctyl]-(2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9-hexadecafluoro-10-(pyren-1-ylmethoxy)decyloxy)acetamide
• CAS: 917232-18-9
• 化学式: C₄₅H₄₄F₁₆N₂O₉
• 分子量: 1060.83
• InChiKey: NZYUGLQPSDPMTQ-UHFFFAOYSA-N

物化性质

• 沸点：
  849.9±65.0 °C(Predicted)
• 密度：
  1.388±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  9.11
• 重原子数：
  72.0
• 可旋转键数：
  32.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.49
• 拓扑面积：
  121.86
• 氢给体数：
  1.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  吗啉 、 N-[8-(bis(allyloxycarbonylmethyl)amino)-3,6-dioxaoctyl]-(2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9-hexadecafluoro-10-(pyren-1-ylmethoxy)decyloxy)acetamide 在 四(三苯基膦)钯 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以37%的产率得到
  参考文献：
  名称：

  The Effect of Receptor Clustering on Vesicle−Vesicle Adhesion

  摘要：

  As part of our studies into how the localization of cell adhesion molecules into lipid rafts may affect cell adhesion, we developed Cu(1), a synthetic copper(iminodiacetate)-capped receptor able to phase separate from fluid phospholipid bilayers. The extent to which Cu(1) clustered into adhesive patches on the surface of vesicles could be controlled by changing vesicle composition. Extensive receptor phase separation significantly enhanced vesicle-vesicle adhesion; only vesicles with adhesive patches (blue fluorescence) adhered to their conjugate histidine-coated vesicles (red fluorescence) to form large vesicle aggregates (shown).

  DOI：

  10.1021/ja0657612
• 作为产物：
  描述：

  烯丙基2-溴乙酸乙酯 在 N,N-二异丙基乙胺 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 77.0h， 生成 N-[8-(bis(allyloxycarbonylmethyl)amino)-3,6-dioxaoctyl]-(2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9-hexadecafluoro-10-(pyren-1-ylmethoxy)decyloxy)acetamide
  参考文献：
  名称：

  The Effect of Receptor Clustering on Vesicle−Vesicle Adhesion

  摘要：

  As part of our studies into how the localization of cell adhesion molecules into lipid rafts may affect cell adhesion, we developed Cu(1), a synthetic copper(iminodiacetate)-capped receptor able to phase separate from fluid phospholipid bilayers. The extent to which Cu(1) clustered into adhesive patches on the surface of vesicles could be controlled by changing vesicle composition. Extensive receptor phase separation significantly enhanced vesicle-vesicle adhesion; only vesicles with adhesive patches (blue fluorescence) adhered to their conjugate histidine-coated vesicles (red fluorescence) to form large vesicle aggregates (shown).

  DOI：

  10.1021/ja0657612