[2-[3-[2-(4-Aminobenzoyl)oxyacetyl]oxypropoxy]-2-oxoethyl] 4-aminobenzoate | 1127406-72-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [2-[3-[2-(4-Aminobenzoyl)oxyacetyl]oxypropoxy]-2-oxoethyl] 4-aminobenzoate
• CAS: 1127406-72-7
• 化学式: C₂₁H₂₂N₂O₈
• 分子量: 430.414
• InChiKey: WBOPZQPHHSAZAO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  31
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  157
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  propane-1,3-diylbis(chloroacetate) 在 Raney-Nickel 氢气 、 三乙胺 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 30.0h， 生成 [2-[3-[2-(4-Aminobenzoyl)oxyacetyl]oxypropoxy]-2-oxoethyl] 4-aminobenzoate
  参考文献：
  名称：

  HYDROLYSABLE LINKERS AND CROSS-LINKERS FOR ABSORBABLE POLYMERS

  摘要：

  本发明涉及一种新型线性和多臂可水解连接剂和交联剂的发现，用于合成可生物降解聚合物，如聚酯、聚氨酯、聚酰胺、聚脲和可降解环氧胺树脂。本发明的线性和多臂可水解连接剂包括对称和/或非对称的醚羧酸、胺、酰胺二醇、胺多元醇和异氰酸。

  公开号：

  US20120197037A1

文献信息

• BIOABSORBABLE POLYMERS FROM BIOABSORBABLE POLYISOCYANATES AND USES THEREOF
  申请人：Bezwada Rao S.

  公开号：US20090292029A1

  公开（公告）日：2009-11-26

  Novel bioabsorbable and/or biocompatible polyurethanes, polyureas, polyamideurethanes and polyureaurethanes with tunable physical, mechanical properties and hydrolytic degradation profiles are provided for use in biomedical applications such as stents, stent coatings, scaffolds, foams, and films. The disclosed polymers may be derived from biocompatible and/or bioabsorbable polyisocyanates. The present invention also relates to new and improved methods for the preparation of the biocompatible and/or bioabsorbable polyisocyanates.

  提供了一种新型的可生物吸收和/或生物相容的聚氨酯、聚脲、聚酰胺-聚氨酯和聚脲-聚氨酯，具有可调节的物理、机械性能和水解降解特性，可用于生物医学应用，如支架、支架涂层、支架、泡沫和薄膜。所披露的聚合物可以来源于生物相容和/或可生物吸收的聚异氰酸酯。本发明还涉及用于制备生物相容和/或可生物吸收聚异氰酸酯的新型和改进的方法。
• FUNCTIONALIZED BIODEGRADABLE TRICLOSAN MONOMERS AND OLIGOMERS FOR CONTROLLED RELEASE
  申请人：Bezwada Rao S.

  公开号：US20090105352A1

  公开（公告）日：2009-04-23

  This invention relates to the discovery of functionalized triclosan monomers and oligomers that, when incorporated into a substrate of, or applied as part of a coating to, medical devices and/or consumer products may extend the duration of antimicrobial properties to the medical devices and/or consumer products.

  这项发明涉及发现的功能化三氯生单体和寡聚体，当它们被纳入医疗设备的基质中，或作为涂层的一部分应用于医疗设备和/或消费品时，可以延长医疗设备和/或消费品的抗菌性能持续时间。
• CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE COMPOUNDS
  申请人：Bezwada Rao S.

  公开号：US20090060979A1

  公开（公告）日：2009-03-05

  The present invention relates to biodegradable polymers (e.g., polyesters and polyester amides) derived from functionalized biologically active compounds that can provide site specific delivery of bioactive compounds upon biodegradation in a controlled manner.

  本发明涉及由功能化的生物活性化合物衍生出的可生物降解聚合物（例如聚酯和聚酰胺），这些聚合物可以在控制的方式下在生物降解时提供生物活性化合物的位点特异性输送。
• Multi-putty adhesive and cement compositions for tissue hemostasis, repair and reconstruction
  申请人：Abyrx, Inc.

  公开号：US11116866B2

  公开（公告）日：2021-09-14

  The disclosure relates to polyurethane and polyureaurethane based putty compositions which harden into a fully cured solid form at room temperature and body temperature and are suitable for use as a bone cement, bone substitute, hard tissue adhesive, or bone hemostatic agent.

  本公开涉及以聚氨酯和聚脲烷为基础的腻子组合物，这些组合物在室温和体温下硬化成完全固化的固体形式，适合用作骨水泥、骨替代物、硬组织粘合剂或骨止血剂。
• BIOABSORBABLE POLYESTERAMIDES AND USES THEREOF
  申请人：Bezwada Rao S.

  公开号：US20090285896A1

  公开（公告）日：2009-11-19

  Novel biodegradable polyesteramides derived from optionally functionalized diacids and optionally functionalized diamines or from compounds having both optionally functionalized acid and optionally functionalized amine moieties, their preparation, and absorbable surgical articles fabricated therefrom, such as monofilament and multifilament sutures, films, sheets, plates, clips, staples, pins, screws, stents, stent coatings, packaging materials, and other implantable surgical devices, and the like, are described herein.