1-[2-hydroxy-2-(2,4-dichlorophenyl)hexyl]imidazole | 70827-17-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[2-hydroxy-2-(2,4-dichlorophenyl)hexyl]imidazole
• 英文别名: 2-(2,4-dichlorophenyl)-1-imidazol-1-ylhexan-2-ol
• CAS: 70827-17-7
• 化学式: C₁₅H₁₈Cl₂N₂O
• 分子量: 313.227
• InChiKey: PYXAKRMMFYLCJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  38
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2’-(1H-咪唑-1-基)-2,4-二氯苯乙酮 在 copper (I) iodide 、 sodium hydride 、 magnesium 作用下， 以 四氢呋喃 、 二甲基亚砜 为溶剂， 反应 3.0h， 生成 1-[2-hydroxy-2-(2,4-dichlorophenyl)hexyl]imidazole
  参考文献：
  名称：

  Bawden; Gymer; Marriott, European Journal of Medicinal Chemistry, 1983, vol. 18, # 1, p. 91 - 96

  摘要：

  DOI：

文献信息

• .beta.-Hydroxyarylethylimidazoles
  申请人：Rohm and Haas Company

  公开号：US04413003A1

  公开（公告）日：1983-11-01

  This invention relates to .beta.-hydroxyarylethylimidazoles, their enantiomorphs, acid addition salts and metal salt complexes. This invention also relates to the method of preparation and use of these compounds. These compounds and salts thereof are highly active broad-spectrum systemic fungicides effective in controlling phytopathgogenic fungi such as barley net blotch (Helminthosporium teres), grey mold (Botrytis cinerea), bean powdery mildew (Erysiphe polygoni), grape downy mildew (Plasmopora viticola), rice blast (Piricularia oryzae), tomato late blight (Phytophthora infestans), and wheat stem rust (Puccinia graminis f. sp. tritici race 15B-2).

  该发明涉及β-羟基芳基乙基咪唑，其对映体，酸盐和金属盐络合物。该发明还涉及这些化合物的制备方法和用途。这些化合物及其盐对诸如大麦网斑病（Helminthosporium teres）、灰霉病（Botrytis cinerea）、豆粉霉病（Erysiphe polygoni）、葡萄霜霉病（Plasmopora viticola）、稻瘟病（Piricularia oryzae）、番茄晚疫病（Phytophthora infestans）和小麦枝锈病（Puccinia graminis f. sp. tritici race 15B-2）等广谱系统性真菌具有高活性，有效控制作用。
• Antifungal imidazole derivatives, process for their preparation and pharmaceutical compositions thereof
  申请人：Pfizer Limited

  公开号：EP0023103A1

  公开（公告）日：1981-01-28

  2-Aryl-2-hydroxy-1-(1-imidazolyl)-alkanes and alkenes of the formula: where R is a straight or branched chain alkyl or alkenyl group of from 2 to 10 carbon atoms or a cycloalkylalkyl group of from 4 to 10 carbon atoms and R' and R2 are each hydrogen, halogen, lower alkyl or lower alkoxy and pharmaceutically acceptable salts thereof are antifungal agents useful in the treatment of fungal infections in animals including humans. Processes for their preparation and pharmaceutical compositions are described.

  式中的 2-芳基-2-羟基-1-(1-咪唑基)-烷烃和烯烃： 其中 R 是 2 至 10 个碳原子的直链或支链烷基或烯基，或 4 至 10 个碳原子的环烷基烷基，R'和 R2 各为氢、卤素、低级烷基或低级烷氧基，以及它们的药学上可接受的盐类是治疗动物（包括人类）真菌感染的抗真菌剂。本文介绍了其制备方法和药物组合物。
• Novel substituted imidazoles and triazoles, fungicidal compositions containing them and the use of the novel compounds for combating fungi
  申请人：ROHM AND HAAS COMPANY

  公开号：EP0076628A2

  公开（公告）日：1983-04-13

  Novel compounds are provided which exhibit fungicidal activity against phytopathogenic fungi. The novel compounds are of Formula I below: wherein: Z is phenyl or naphthyl each being optionally substituted with up to three of the same or different substituents selected from halogen, nitro, trihalomethyl, cyano, (C1-C6)alkyl, (C1-C6)alkoxy, (C,-Ce)alkylthio, (C1-C6)alkylsulfinyl, (C1-C6) alkylsulfonyl and (C2-Ce)alkenyl; R' is hydrogen, (C1-C12)alkyl, (C3-C8)cycloalkyl, (C2-C8)alkenyl, (C5-C8)cycloalkenyl, (C2-C8)alkynyl, phenyl, naphthyl each of the last groups being optionally substituted with up to three of the same or different substituents selected from halogen, nitro, trihalomethyl, cyano, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)-alkynyl, (C1-C6)alkoxy, (C,-C6)alkylsulfinyl and (C1-C6)alkylsulfonyl; R2 is hydrogen, phenyl optionally substituted with up to three of the same or different substituents selected from nitro, trihalomethyl, cyano, (C1-C6)alkyl, (C2-Ce)alkenyl, (C2-C6)alkynyl, (C1-C6)alkoxy, (C1-C6)alkylsulfinyl and (C1-C6)-alkylsulfonyl; and Q is 1-imidazolyl, or 1- or 4-(1,2,4-triazolyl).

  本发明提供了对植物病原真菌具有杀菌活性的新型化合物。这些新型化合物如下式 I 所示： 其中 Z 是苯基或萘基，每个苯基或萘基任选被至多三个相同或不同的取代基取代，这些取代基选自卤素、硝基、三卤甲基、氰基、(C1-C6)烷基、(C1-C6)烷氧基、(C,-Ce)烷硫基、(C1-C6)烷基亚磺酰基、(C1-C6)烷基磺酰基和(C2-Ce)烯基； R'是氢、(C1-C12)烷基、(C3-C8)环烷基、(C2-C8)烯基、(C5-C8)环烯基、(C2-C8)炔基、苯基、萘基，最后每个基团可任选被至多三个相同或不同的取代基取代，这些取代基选自卤素、硝基、三卤甲基、氰基、(C1-C6)烷基、(C2-C6)烯基、(C2-C6)炔基、(C1-C6)烷氧基、(C,-C6)烷基亚磺酰基和(C1-C6)烷基磺酰基； R2 是氢、可任选被最多三个相同或不同取代基取代的苯基，这些取代基选自硝基、三卤甲基、氰基、(C1-C6)烷基、(C2-Ce)烯基、(C2-C6)炔基、(C1-C6)烷氧基、(C1-C6)烷基亚磺酰基和(C1-C6)-烷基磺酰基；以及 Q 是 1-咪唑基，或 1-或 4-(1,2,4-三唑基)。
• BAWDEN, D.;GYMER, G. E.;MARRIOTT, M. S.;TUTE, M. S., EUR. J. MED. CHEM.-CHIM. THER., 1983, 18, N 1, 91-96
  作者：BAWDEN, D.、GYMER, G. E.、MARRIOTT, M. S.、TUTE, M. S.

  DOI：——

  日期：——
• MILLER, G. A.;HAK-FOON, CHAN
  作者：MILLER, G. A.、HAK-FOON, CHAN

  DOI：——

  日期：——