cyclohexyl-1,4-dicarbamic acid | 40200-14-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: cyclohexyl-1,4-dicarbamic acid
• 英文别名: 1,4-cyclohexane dicarbamate；[4-(Carboxyamino)cyclohexyl]carbamic acid
• CAS: 40200-14-4
• 化学式: C₈H₁₄N₂O₄
• 分子量: 202.21
• InChiKey: OTVLKBIPXOBNDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  98.7
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  二氧化碳 、 1,4-环己烷二胺 在 Ru/Al2O3 、 水 作用下， 生成 cyclohexyl-1,4-dicarbamic acid
  参考文献：
  名称：

  Catalytic hydrogenation of 1,4-phenylenediamine to 1,4-cyclohexanediamine

  摘要：

  Catalytic hydrogenation of 1,4-phenylenediamine to 1,4-cyclohexanediamine using Ru/Al2O3 as a catalyst was carried out in water, and the results were compared with those in isopropanol and SC-CO2. 80% 1,4-phenylenediamine conversion with 87% selectivity to 1,4-cyclohexanediamine was achieved on 5% Ru/Al2O3 catalyst at 90A degrees C and H-2 pressure of 4 MPa. The hydrogenation of 1,4-phenylenediamine is influenced by the solvent. A systematic study of the hydrogenation of 1,4-phenylenediamine revealed that the reaction was consecutive. The longer the time, the lower was the CHDA selectivity. Also, the reaction temperature was an important parameter and played a vital role in preventing the formation of side products.

  DOI：

  10.1134/s1070427214030239

文献信息

• PARTICULATE CARBAMATE FUNCTIONAL COMPOUNDS AND POWDER COATINGS COMPRISING THE SAME
  申请人：BASF CORPORATION

  公开号：EP1159360B1

  公开（公告）日：2004-08-18
• POWDER SLURRY COATING COMPOSITION CONTAINING PARTICULATE CARBAMATE FUNCTIONAL COMPOUNDS AND A LIQUID COMPONENT
  申请人：Basf Corporation

  公开号：EP1159361B1

  公开（公告）日：2002-10-02
• COMPOUNDS AND METHODS FOR CD73 MODULATION AND INDICATIONS THEREFOR
  申请人：Plexxikon Inc.

  公开号：US20210198239A1

  公开（公告）日：2021-07-01

  Disclosed are compounds of Formula I: or a pharmaceutically acceptable salt, a solvate, a tautomer, a stereoisomer or a deuterated analog thereof, wherein R 1 , R 2 , R 3 , A, L, and G are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.
• [EN] METHOD FOR THE PRODUCTION OF POLYOXAZOLIDINONE POLYMER COMPOUNDS<br/>[FR] PROCÉDÉ DE PRODUCTION DE COMPOSÉS POLYMÈRES DE POLYOXAZOLIDINONE
  申请人：COVESTRO DEUTSCHLAND AG

  公开号：WO2018141743A1

  公开（公告）日：2018-08-09

  Method for the production of polyoxazolidinone compounds, comprising the reaction of at least one biscarbamate compound (A) with at least one bisepoxide compound (B) in the presence of at least one base (D), at least one Lewis acid catalyst (E), and optionally at least one compound (C), wherein the compound (C) comprising a mono-carbamate group, a mono-isocyanate group and/or a mono-epoxide group, and wherein the base (D) having a pKb-value of < 9. The invention is also related to the resulting polyoxazolidinone compounds.