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(4R)-2-[4-acetylthio-2-oxoazetidin-1-yl]-2-triphenylphosphoranylideneacetic acid p-nitrobenzyl ester | 71053-51-5

中文名称
——
中文别名
——
英文名称
(4R)-2-[4-acetylthio-2-oxoazetidin-1-yl]-2-triphenylphosphoranylideneacetic acid p-nitrobenzyl ester
英文别名
p-nitrobenzyl 2-(4-acetylthio-2-oxo-1-azetidinyl)-2-triphenylphosphoranylideneacetate;(2-acetylsulfanyl-4-oxo-azetidin-1-yl)-(triphenyl-λ5-phosphanylidene)-acetic acid 4-nitro-benzyl ester;(4-nitrophenyl)methyl 2-(2-acetylsulfanyl-4-oxoazetidin-1-yl)-2-(triphenyl-λ5-phosphanylidene)acetate
(4R)-2-[4-acetylthio-2-oxoazetidin-1-yl]-2-triphenylphosphoranylideneacetic acid p-nitrobenzyl ester化学式
CAS
71053-51-5
化学式
C32H27N2O6PS
mdl
——
分子量
598.616
InChiKey
KJSFJULORFCISX-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    5.4
  • 重原子数:
    42
  • 可旋转键数:
    10
  • 环数:
    5.0
  • sp3杂化的碳原子比例:
    0.12
  • 拓扑面积:
    135
  • 氢给体数:
    0
  • 氢受体数:
    7

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量
  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

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文献信息

  • Antibacterial agents, and 4-thio azetidinone intermediates
    申请人:Bristol-Myers Company
    公开号:US04272437A1
    公开(公告)日:1981-06-09
    This invention relates to 2-substituted and 2,6-disubstituted penem compounds of the formula ##STR1## wherein Y is hydrogen, halo or certain organic substituents and X represents certain organic substituents. Also included in the invention are pharmaceutically acceptable salts of the above compounds and derivatives of the above compounds in which the carboxyl group at the 3-position is protected as by an easily removable ester protecting group. The compounds of the present invention are potent antibacterial agents or are of use as intermediates in the preparation of such agents.
    本发明涉及2-取代和2,6-二取代的青霉烯化合物,其公式为##STR1##,其中Y是氢、卤素或某些有机取代基,X代表某些有机取代基。发明还包括上述化合物的药用可接受盐和上述化合物的衍生物,其中3位的羧基被易于移除的酯保护基团所保护。本发明的化合物是强效的抗菌剂,或可用于制备此类药物的中间体。
  • Thia-aza compounds with a .beta.-lactam ring
    申请人:Ciba-Geigy Corporation
    公开号:US04331676A1
    公开(公告)日:1982-05-25
    2-Penem-3-carboxylic acid compounds of the formula ##STR1## in which R.sub.1 represents hydrogen, an organic radical bonded by a carbon atom to the ring carbon atom or an etherified mercapto group and R.sub.2 represents hydroxy or a radical R.sub.2.sup.A forming together with the carbonyl grouping --C(.dbd.O)-- a protected carboxyl group, 1-oxides thereof, as well as salts of such compounds having salt-forming groups, in racemic and optically active form, processes for their preparation, pharmaceutical compositions containing such compounds, and their use as antibiotics, and intermediates and their processes which are useful in the production of the compounds of the formula I.
    公式为##STR1##的2-青霉素-3-羧酸化合物,其中R.sub.1代表氢,由碳原子与环碳原子结合的有机基团或醚化巯基团,R.sub.2代表羟基或与羰基团--C(.dbd.O)--一起形成保护羧基的基团R.sub.2.sup.A,其1-氧化物,以及具有形成盐的盐基团的这种化合物的盐,以拉克米和光学活性形式存在,它们的制备方法,含有这种化合物的药物组合物,以及它们作为抗生素的用途,以及在生产公式I化合物中有用的中间体及其制备方法。
  • 2-Methylpenem-3-carboxylic acid antibiotics
    申请人:Bristol-Myers Company
    公开号:US04155912A1
    公开(公告)日:1979-05-22
    There is described the preparation of novel 2-penem-3-carboxylic acid compounds having the formula ##STR1## and easily cleavable esters and carboxylic acid salts thereof. The compounds of formula I, particularly the dextrorotatory isomers thereof, are potent antibacterial agents or are of use as intermediates in the preparation of such agents.
    描述了制备新型2-青霉烷-3-羧酸化合物的方法,其化学式为##STR1##以及易于水解的酯和羧酸盐。式I的化合物,特别是它们的右旋异构体,是有效的抗菌剂,或者可用作制备这种药剂的中间体。
  • Novel phosphorane intermediates for use in preparing penem antibiotics
    申请人:Bristol-Myers Company
    公开号:US04169833A1
    公开(公告)日:1979-10-02
    Disclosed are novel phosphorane intermediates of the formula ##STR1## wherein Z is phenyl or C.sub.1 -C.sub.6 alkyl. The intermediates are of use in preparing 2-penem-3-carboxylic acid compounds having potent antibacterial activity.
    本发明涉及一种新型的磷酰胺中间体,其化学式为 ##STR1## 其中Z为苯基或C.sub.1-C.sub.6烷基。这些中间体可用于制备具有强效抗菌活性的2-青霉烷-3-羧酸化合物。
  • Antibacterial agents and metal containing azetidinone intermediates
    申请人:Bristol Myers Company
    公开号:US04378314A1
    公开(公告)日:1983-03-29
    This invention relates to 2-substituted and 2,6-disubstituted penem compounds of the formula ##STR1## wherein Y is hydrogen, halo or certain organic substituents and X represents certain organic substituents. Also included in the invention are pharmaceutically acceptable salts of the above compounds and derivatives of the above compounds in which the carboxyl group at the 3-position is protected as by an easily removable ester protecting group. The compounds of the present invention are potent antibacterial agents or are of use as intermediates in the preparation of such agents.
    本发明涉及公式为 ##STR1## 的2-取代和2,6-二取代的青霉烷类化合物,其中Y为氢、卤素或某些有机取代基,X代表某些有机取代基。本发明还包括上述化合物的药学上可接受的盐以及上述化合物的衍生物,其中3-位上的羧基被易于去除的酯保护基保护。本发明的化合物是有效的抗菌剂,或者用作制备这种剂的中间体。
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