4-(Diphenyl-phosphinoyl)-6-phenyl-4,5-dihydro-2H-pyridazin-3-one | 266001-31-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-(Diphenyl-phosphinoyl)-6-phenyl-4,5-dihydro-2H-pyridazin-3-one
• 英文别名: 4-(diphenylphosphoryl)-6-phenyl-4,5-dihydropyridazin-3(2H)-one；5-diphenylphosphoryl-3-phenyl-4,5-dihydro-1H-pyridazin-6-one
• CAS: 266001-31-4
• 化学式: C₂₂H₁₉N₂O₂P
• 分子量: 374.379
• InChiKey: VCERTAWDAJLQIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  58.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(Diphenyl-phosphinoyl)-6-phenyl-4,5-dihydro-2H-pyridazin-3-one 在 溴 、 溶剂黄146 作用下， 反应 3.0h， 以94%的产率得到4-(Diphenyl-phosphinoyl)-6-phenyl-2H-pyridazin-3-one
  参考文献：
  名称：

  ACTION DES HYDRAZINES SUR LES γ,β'-DICARBONYLPHOSPHONATES ET PHOSPHINEOXIDES: SYNTHESE DE 4-PHOSPHOPYRIDAZINES ET PYRIDAZIN-3-ONES

  摘要：

  gamma,beta'-Dicarbonylphosphonates and phosphincoxides 1 and 2 react with hydrazines to give 4-phosphopyridazine and pyridazin-3-one derivatives 3, 4 and 5, 4-Phosphodihydro-pyridazin-3-ones 5 were dehydrogenated by the action of bromine in acetic acid to give phosphopyridazinones 6. The structure of all obtained products is confirmed by NMR and IR spectroscopy.

  DOI：

  10.1080/10426509808043626
• 作为产物：
  描述：

  3-苯甲酰丙烯酸 在 一水合肼 作用下， 以 乙醇 、 苯 为溶剂， 反应 14.0h， 生成 4-(Diphenyl-phosphinoyl)-6-phenyl-4,5-dihydro-2H-pyridazin-3-one
  参考文献：
  名称：

  Synthesis and Heterocyclization of β-Aroyl- -diphenylphosphorylpropionic Acids

  摘要：

  DOI：

  10.1023/b:cohc.0000033535.93962.f5

文献信息

• ACTION DES HYDRAZINES SUR LES γ,β'-DICARBONYLPHOSPHONATES ET PHOSPHINEOXIDES: SYNTHESE DE 4-PHOSPHOPYRIDAZINES ET PYRIDAZIN-3-ONES
  作者：Soufiane Touil、Hedi Zantour

  DOI：10.1080/10426509808043626

  日期：1998.3.1

  gamma,beta'-Dicarbonylphosphonates and phosphincoxides 1 and 2 react with hydrazines to give 4-phosphopyridazine and pyridazin-3-one derivatives 3, 4 and 5, 4-Phosphodihydro-pyridazin-3-ones 5 were dehydrogenated by the action of bromine in acetic acid to give phosphopyridazinones 6. The structure of all obtained products is confirmed by NMR and IR spectroscopy.
• Synthesis and Heterocyclization of β-Aroyl- -diphenylphosphorylpropionic Acids
  作者：R. A. Khachatryan、R. J. Khachikyan、N. V. Karamyan、G. A. Panosyan、M. G. Indzhikyan

  DOI：10.1023/b:cohc.0000033535.93962.f5

  日期：2004.4