3,4-dibromo-2-methoxypyridine | 96245-99-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3,4-dibromo-2-methoxypyridine
• 英文别名: 4-BromoBromo-2-methoxypyridine
• CAS: 96245-99-7
• 化学式: C₆H₅Br₂NO
• 分子量: 266.92
• InChiKey: MDNNKSIDESQBCS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3,4-dibromo-2-methoxypyridine 、 三甲基乙炔基硅 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 三乙胺 、 三苯基膦 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 以62%的产率得到3,4-diethynyl-2-methoxypyridine
  参考文献：
  名称：

  Rearrangements of azabiphenylenes. The impact of nitrogen number and position

  摘要：

  DOI：

  10.1021/jo00214a012
• 作为产物：
  描述：

  2,4-二羟基吡啶 在 sodium methylate 、 三溴氧磷 作用下， 以 甲醇 为溶剂， 反应 1.25h， 生成 3,4-dibromo-2-methoxypyridine
  参考文献：
  名称：

  Rearrangements of azabiphenylenes. The impact of nitrogen number and position

  摘要：

  DOI：

  10.1021/jo00214a012

文献信息

• [EN] (1-AZINONE) -SUBSTITUTED PYRIDOINDOLES AS MCH ANTAGONISTS<br/>[FR] PYRIDOINDOLES (1-AZINONE)-SUBSTITUÉS EN TANT QU'ANTAGONISTES MCH
  申请人：ALBANY MOLECULAR RES INC

  公开号：WO2009089482A1

  公开（公告）日：2009-07-16

  Substituted pyridoindoles for incorporation in pharmaceutical compositions employed in the treatment of various diseases correspond to formula (I) wherein R1 is H or optionally substituted alkyl; R2, R3, R4 are each independently selected from H, -O-alkyl, -S-alkyl, alkyl, halo, -CF3, and -CN; G is -CR12R13-NR5- or -NR5-CR12R13; R5 is H, optionally substituted alkyl, optionally substituted heterocycle, -C(=O)-R6, -C(=O)-O-R7, or -C(=O)-NR19R20; R6 and R7 are each optionally substituted alkyl or optionally substituted heterocycle; R8, R9, R10, R11, R12, R13, R19 and R20 are each independently selected from H or optionally substituted alkyl; R14 and R15 are each independently H or halogen; L is -CH2-O-, -CH2CH2-, -CH=CH- or a bond; and B is aryl or heteroaryl or cycloalkyl; with the proviso that, when L is a direct bond, B cannot be unsubstituted heteroaryl or heteroaryl monosubstituted with fluorine.

  将吡啶吲哚替代物用于制药组合物中，用于治疗各种疾病，对应于式（I），其中R1为H或可选择的取代烷基；R2、R3、R4分别独立选择自H、-O-烷基、-S-烷基、烷基、卤素、-CF3和-CN；G为-CR12R13-NR5-或-NR5-CR12R13；R5为H、可选择的取代烷基、可选择的取代杂环、-C(=O)-R6、-C(=O)-O-R7或-C(=O)-NR19R20；R6和R7分别为可选择的取代烷基或可选择的取代杂环；R8、R9、R10、R11、R12、R13、R19和R20分别独立选择自H或可选择的取代烷基；R14和R15分别独立为H或卤素；L为-CH2-O-、-CH2CH2-、-CH=CH-或一个键；B为芳基或杂芳基或环烷基；但条件是，当L为直接键时，B不能是未取代的杂芳基或单取代氟的杂芳基。
• 3-benzoyl-2,4,5-substituted pyridine derivatives or salts thereof and bactericides containing the same
  申请人：Nishide Hisaya

  公开号：US20060089390A1

  公开（公告）日：2006-04-27

  To provide 3-benzoyl-2,4,5-substituted pyridine derivatives or their salts, fungicides containing them, and intermediates for producing them. By providing a group of compounds comprising specific 3-benzoyl-2,4,5-substituted pyridine derivatives or their salts, or fungicides containing them, which have so-called rainfastness, whereby they are capable of exhibiting excellent effects even when crops have received rainfall after application of the chemicals, it becomes unnecessary to increase the number of applications or the dose of the chemicals by taking into consideration the rainfall after the application of the chemicals. Thus, it is possible to protect crops from disease injuries at a lower cost with less labor.

  提供3-苯甲酰基-2,4,5-取代吡啶衍生物或其盐，含有它们的杀菌剂以及用于生产它们的中间体。通过提供一组化合物，其中包括特定的3-苯甲酰基-2,4,5-取代吡啶衍生物或其盐，或含有它们的杀菌剂，这些化合物具有所谓的雨水稳定性，即使作物在化学品施用后遭受降雨，它们仍能展现出优异的效果，因此不必考虑化学品施用后的降雨增加化学品的施用次数或剂量。因此，可以以更低的成本和更少的劳动力保护作物免受病害的伤害。
• (1-AZINONE)-SUBSTITUTED PYRIDOINDOLES
  申请人：GUZZO Peter Robert

  公开号：US20090275590A1

  公开（公告）日：2009-11-05

  Substituted pyridoindoles for incorporation in pharmaceutical compositions employed in the treatment of various diseases correspond to formula (I) wherein R 1 is H or optionally substituted alkyl; R 2 , R 3 , R 4 are each independently selected from H, —O-alkyl, —S-alkyl, alkyl, halo, —CF 3 , and —CN; G is —CR 12 R 13 —NR 5 — or —NR 5 —CR 12 R 13 ; R 5 ; is H, optionally substituted alkyl, optionally substituted heterocycle, —C(═O)—R 6 , —C(═O)—O—R 7 , or —C(═O)—NR 19 R 20 ; R 6 and R 7 are each optionally substituted alkyl or optionally substituted heterocycle; R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , R 19 and R 20 are each independently selected from H or optionally substituted alkyl; R 14 and R 15 are each independently H or halogen; L is —CH 2 —O—, —CH 2 CH 2 —, —CH═CH— or a bond; and B is aryl or heteroaryl or cycloalkyl; with the proviso that, when L is a direct bond, B cannot be unsubstituted heteroaryl or heteroaryl monosubstituted with fluorine.

  替代吡啶并吡唑类化合物可用于制备用于治疗各种疾病的药物组合物，其对应于式（I），其中R1是H或可选择的取代烷基; R2，R3，R4分别选自H，—O-烷基，—S-烷基，烷基，卤素，—CF3和—CN; G是—CR12R13—NR5—或—NR5—CR12R13; R5;是H，可选择的取代烷基，可选择的取代杂环，—C（═O）—R6，—C（═O）—O—R7或—C（═O）—NR19R20; R6和R7分别是可选择的取代烷基或可选择的取代杂环; R8，R9，R10，R11，R12，R13，R19和R20分别选自H或可选择的取代烷基; R14和R15分别是H或卤素; L是—CH2—O—，—CH2CH2—，—CH═CH—或键; B是芳基或杂芳基或环烷基; 前提是，当L是直接键时，B不能是未取代的杂芳基或单取代氟的杂芳基。
• (1-azinone)-substituted pyridoindoles
  申请人：Guzzo Peter

  公开号：US08716308B2

  公开（公告）日：2014-05-06

  Substituted pyridoindoles for incorporation in pharmaceutical compositions employed in the treatment of various diseases correspond to formula (I) wherein R1 is H or optionally substituted alkyl; R2, R3, R4 are each independently selected from H, —O-alkyl, —S-alkyl, alkyl, halo, —CF3, and —CN; G is —CR12R13—NR5— or —NR5—CR12R13; R5; is H, optionally substituted alkyl, optionally substituted heterocycle, —C(═O)—R6, —C(═O)—O—R7, or —C(═O)—NR19R20; R6 and R7 are each optionally substituted alkyl or optionally substituted heterocycle; R8, R9, R10, R11, R12, R13, R19 and R20 are each independently selected from H or optionally substituted alkyl; R14 and R15 are each independently H or halogen; L is —CH2—O—, —CH2CH2—, —CH═CH— or a bond; and B is aryl or heteroaryl or cycloalkyl; with the proviso that, when L is a direct bond, B cannot be unsubstituted heteroaryl or heteroaryl monosubstituted with fluorine.

  替代吡啶并吡咯类化合物可用于制备用于治疗各种疾病的药物组合物，其化学式为(I)，其中R1为H或可选取代的烷基; R2、R3、R4各自独立地选自H、-O-烷基、-S-烷基、烷基、卤素、-CF3和-CN; G为-CR12R13-NR5-或-NR5-CR12R13; R5为H、可选取代的烷基、可选取代的杂环、-C(═O)-R6、-C(═O)-O-R7或-C(═O)-NR19R20; R6和R7各自为可选取代的烷基或可选取代的杂环; R8、R9、R10、R11、R12、R13、R19和R20各自独立地选自H或可选取代的烷基; R14和R15各自独立地为H或卤素; L为-CH2-O-、-CH2CH2-、-CH═CH-或键; B为芳基、杂芳基或环烷基; 前提是当L为直接键时，B不能是未取代的杂芳基或单取代氟的杂芳基。
• Formal Halogen Transfer of Bromoarenes via Stepwise Reactions
  作者：Kengo Inoue、Atsunori Mori、Kentaro Okano

  DOI：10.1021/acs.orglett.3c02540

  日期：2023.9.15

  A two-step halogen transfer of bromoarenes is reported. Mono-, di-, and tribromoaryllithiums generated through deprotonative lithiation were converted into organozinc species by in situ zincation, which were then subjected to bromination to provide the corresponding di-, tri-, and tetrabromoarenes, respectively, in 41–95% yields. Regioselective bromine–magnesium exchange with ethylmagnesium chloride

  报道了溴代芳烃的两步卤素转移。通过去质子锂化产生的单溴芳基锂、二溴芳基锂和三溴芳基锂通过原位锌化转化为有机锌物质，然后进行溴化，分别提供相应的二溴芳烃、三溴芳烃和四溴芳烃，产率 41-95%。与乙基氯化镁进行区域选择性溴-镁交换，然后进行亲电捕获，得到苯、吡啶、喹啉、嘧啶和噻唑衍生物，其中溴基团从原始位置转移，产率为 28-86%。