2-(苄基氨基)-4-氯苯甲酸 | 1026-33-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(苄基氨基)-4-氯苯甲酸
• 英文名称: 2-(benzylamino)-4-chlorobenzoic acid
• 英文别名: 4-Chlor-(2-benzyl-amino)-benzoesaeure
• CAS: 1026-33-1
• 化学式: C₁₄H₁₂ClNO₂
• 分子量: 261.708
• InChiKey: JHRXFPUUMCFNLQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(苄基氨基)-4-氯苯甲酸 在 copper(l) iodide 、 potassium carbonate 作用下， 以 二甲基亚砜 为溶剂， 反应 6.0h， 生成 7-chloro-2-phenyl-4H-benzo[d][1,3]oxazin-4-one
  参考文献：
  名称：

  Copper catalyzed CN bond formation/C–H activation: synthesis of aryl 4H-3,1-benzoxazin-4-ones

  摘要：

  We have developed a practical and efficient synthesis of 2-phenyl-4H-benzo[d][1,3]oxazine-4-one derivatives through copper catalyzed tandem reaction of 2-iodobenzoic acid with arylmethanamines under aerobic conditions. Compared to the literature methods toward the synthesis of 2-phenyl-4H-benzo[d][1,3]oxazine-4-one, the synthetic method reported in this Letter has broad substrate scope, mild reaction condition, and uses an inexpensive catalyst. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.11.070
• 作为产物：
  描述：

  4-氯-2-碘苯甲酸 、 苄胺 在 copper(l) iodide 、 potassium carbonate 作用下， 以 二甲基亚砜 为溶剂， 反应 6.0h， 生成 2-(苄基氨基)-4-氯苯甲酸
  参考文献：
  名称：

  Copper catalyzed CN bond formation/C–H activation: synthesis of aryl 4H-3,1-benzoxazin-4-ones

  摘要：

  We have developed a practical and efficient synthesis of 2-phenyl-4H-benzo[d][1,3]oxazine-4-one derivatives through copper catalyzed tandem reaction of 2-iodobenzoic acid with arylmethanamines under aerobic conditions. Compared to the literature methods toward the synthesis of 2-phenyl-4H-benzo[d][1,3]oxazine-4-one, the synthetic method reported in this Letter has broad substrate scope, mild reaction condition, and uses an inexpensive catalyst. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.11.070

文献信息

• [EN] FUROSEMIDE ANALOGUES AND COMPOSITIONS AND USES THEREOF FOR TREATMENT OF ALZHEIMER'S DISEASE<br/>[FR] ANALOGUES DE FUROSÉMIDE, COMPOSITIONS ET UTILISATIONS ASSOCIÉES POUR LE TRAITEMENT DE LA MALADIE D'ALZHEIMER
  申请人：UNIV HEALTH NETWORK

  公开号：WO2020257940A1

  公开（公告）日：2020-12-30

  The present application provides furosemide analogues of the general formula Z having activity as anti-Aβ aggregation agents and/or as inhibitors of Aβ induced neuroinflammation. Formula Z These compounds are useful in preventing, delaying and/or treating Alzheimer's Disease. Accordingly, the present application further provides pharmaceutical compositions and method for preventing, delaying and/or treating Alzheimer's Disease.

  本申请提供了一般公式Z的呋塞米类似物，具有作为抗Aβ聚集剂和/或抑制Aβ诱导的神经炎症的活性。这些化合物在预防、延迟和/或治疗阿尔茨海默病方面是有用的。因此，本申请还提供了用于预防、延迟和/或治疗阿尔茨海默病的药物组合物和方法。
• ARTHROPODICIDAL PYRAZOLINES
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0506709A1

  公开（公告）日：1992-10-07
• [EN] ARTHROPODICIDAL PYRAZOLINES
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：WO1991008207A1

  公开（公告）日：1991-06-13

  (EN) Arthropodicidal pyrazolines of formula (I), where X, O or S and Q is formula (II), where F completes a fused benzene, pyridine or thiopene ring, and formula (III), where A is SO2, C(O) or CRaRb, n'=0 or 1.(FR) Pyrazolines arthropodicides présentant la formule (I) dans laquelle X, O ou S et Q représentent la formule (II) dans laquelle F complète un anneau benzène, pyridine ou thiopène fusionné, et la formule (III) dans laquelle A représente SO2, C(O) ou CRaRb, n'=0 ou 1.
• Copper catalyzed CN bond formation/C–H activation: synthesis of aryl 4H-3,1-benzoxazin-4-ones
  作者：Sathishkumar Munusamy、Sathesh Venkatesan、Kulathu Iyer Sathiyanarayanan

  DOI：10.1016/j.tetlet.2014.11.070

  日期：2015.1

  We have developed a practical and efficient synthesis of 2-phenyl-4H-benzo[d][1,3]oxazine-4-one derivatives through copper catalyzed tandem reaction of 2-iodobenzoic acid with arylmethanamines under aerobic conditions. Compared to the literature methods toward the synthesis of 2-phenyl-4H-benzo[d][1,3]oxazine-4-one, the synthetic method reported in this Letter has broad substrate scope, mild reaction condition, and uses an inexpensive catalyst. (C) 2014 Elsevier Ltd. All rights reserved.