2-乙酰氧基甲基-3-甲基丁基乙酸酯 | 1056741-39-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-乙酰氧基甲基-3-甲基丁基乙酸酯
• 英文名称: 2-acetoxymethyl-3-methyl butyl acetate
• 英文别名: 2-Isopropyl-1,3-diacetoxypropane；[2-(acetyloxymethyl)-3-methylbutyl] acetate
• CAS: 1056741-39-9
• 化学式: C₁₀H₁₈O₄
• 分子量: 202.251
• InChiKey: LRORSVOMAIYRFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-乙酰氧基甲基-3-甲基丁基乙酸酯 生成 (r)-2-Hydroxymethyl-3-methylbutan-1-yl acetate
  参考文献：
  名称：

  RAMOS, TOMBO G. M.;SCHAER, H. -P.;FERNANDEZ, I BUSQUETS X.;GHISALBA, O., BIOCATAL. ORG. MEDIA: PROC. INT. SYMP., WAGENINGEN, 7-10 DEC., 1986, AMST+

  摘要：

  DOI：
• 作为产物：
  描述：

  2-isopropylpropan-1,3-diol 、 乙酰氯 反应 24.0h， 以87%的产率得到2-乙酰氧基甲基-3-甲基丁基乙酸酯
  参考文献：
  名称：

  用于合成肽基烯烃肽模拟物的光学活性 γ-羟基砜 Julia 试剂

  摘要：

  肽基烯烃肽模拟物用作生物活性化合物或用作其他肽基等排体的中间体。我们开发了一种化学酶立体选择性方法，用于通过 Julia 反应将光学活性 γ-羟基砜组装成肽基烯烃。前手性二酯到相应羟基酯的关键酶水解引入了光学活性。随后的化学反应顺序，无论是保护-水解-功能化还是功能化-水解-保护，决定了最终砜结构单元的绝对立体化学。（© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008 )

  DOI：

  10.1002/ejoc.200800334

文献信息

• Optically Active N- and C-Terminal Building Blocks for the Synthesis of Peptidyl Olefin Peptidomimetics
  作者：Sima Mirilashvili、Naama Chasid-Rubinstein、Amnon Albeck

  DOI：10.1002/ejoc.201000539

  日期：2010.8

  peptidomimetics serve as biologically active compounds or as intermediates for other peptidyl isosteres. The N-terminal side of the C=C bond could be easily prepared in an optically pure form from α-amino acids. Synthesis of C-terminal building blocks in an optically pure form is more challenging. We developed a chemoenzymatic stereoselective approach to such optically active C-terminal building blocks to

  肽基烯烃肽模拟物用作生物活性化合物或用作其他肽基等排体的中间体。C=C 键的 N 端侧可以很容易地从 α-氨基酸以光学纯的形式制备。以光学纯形式合成 C 端结构单元更具挑战性。我们开发了一种化学酶立体选择性方法，用于通过各种反应组装成肽基烯烃的光学活性 C 端结构单元。它们包括亲电子醛和亲核砜、鏻盐、膦酸盐和二硒化物。前手性二酯到相应羟基酯的关键酶水解引入了光学活性。随后化学反应的顺序，无论是保护-水解-功能化还是功能化-水解-保护，
• CATALYST COMPONENT FOR OLEFIN POLYMERIZATION AND CATALYST THEREOF
  申请人：China Petroleum&Chemical Corporation

  公开号：EP3135697A1

  公开（公告）日：2017-03-01

  The present invention provides a catalyst component for olefin polymerization, obtained by a reaction of magnesium, titanium, halogen and an internal electron donor, the internal electron donor comprising an imine compound as shown in Formula Z. The present invention also provides a preparation method of the catalyst component, and a catalyst for olefin polymerization containing the same. When the catalyst of the present invention is used for olefin polymerization reaction, the catalyst has a high activity, and a slow rate of activity decay, and the obtained polymer has a high isotacticity index, and a wide molecular weight distribution.

  本发明提供了一种烯烃聚合催化剂组分，由镁、钛、卤素和内电子供体反应得到，内电子供体包括如式Z所示的亚胺化合物，本发明还提供了该催化剂组分的制备方法，以及含有该催化剂组分的烯烃聚合催化剂。本发明的催化剂用于烯烃聚合反应时，催化剂活性高，活性衰减速度慢，得到的聚合物等活度指数高，分子量分布广。
• CATALYST COMPONENT FOR USE IN OLEFIN POLYMERIZATION, CATALYST, AND APPLICATIONS THEREOF
  申请人：China Petroleum & Chemical Corporation

  公开号：EP3517553A1

  公开（公告）日：2019-07-31

  Disclosed is a catalyst component for olefin polymerization. The catalyst component comprises magnesium, titanium, halogen and an internal electron donor. The internal electron donor includes an imine compound with a ketone group as shown in Formula I. Disclosed further is a method of preparing the catalyst component, and a catalyst for olefin polymerization containing the catalyst component. When the catalyst is used in olefin polymerization reaction especially propene polymerization reaction, the catalyst has a high long-term activity and good hydrogen response, and the obtained polymer has characteristics of an adjustable isotactic index and a relatively wide molecular weight distribution.

  公开了一种用于烯烃聚合的催化剂组分。催化剂组分包括镁、钛、卤素和内部电子供体。内部电子供体包括如式 I 所示的带有酮基的亚胺化合物。进一步公开的是制备催化剂组分的方法，以及含有该催化剂组分的烯烃聚合催化剂。当催化剂用于烯烃聚合反应，特别是丙烯聚合反应时，催化剂具有较高的长期活性和良好的氢响应，得到的聚合物具有可调节的同素异形指数和相对较宽的分子量分布。
• Catalyst component for olefin polymerization, and catalyst containing the same
  申请人：China Petroleum & Chemical Corporation

  公开号：US10208145B2

  公开（公告）日：2019-02-19

  The present invention provides a catalyst component for olefin polymerization, obtained by a reaction of magnesium, titanium, halogen and an internal electron donor, the internal electron donor comprising an imine compound as shown in Formula Z. The present invention also provides a preparation method of the catalyst component, and a catalyst for olefin polymerization containing the same. When the catalyst of the present invention is used for olefin polymerization reaction, the catalyst has a high activity, and a slow rate of activity decay, and the obtained polymer has a high isotacticity index, and a wide molecular weight distribution.

  本发明提供了一种烯烃聚合催化剂组分，由镁、钛、卤素和内电子供体反应得到，内电子供体包括如式Z所示的亚胺化合物，本发明还提供了该催化剂组分的制备方法，以及含有该催化剂组分的烯烃聚合催化剂。本发明的催化剂用于烯烃聚合反应时，催化剂活性高，活性衰减速度慢，得到的聚合物等活度指数高，分子量分布广。
• Catalyst component for olefin polymerization, catalyst, and use thereof
  申请人：CHINA PETROLEUM & CHEMICAL CORPORATION

  公开号：US10662268B2

  公开（公告）日：2020-05-26

  Disclosed is a catalyst component for olefin polymerization. The catalyst component comprises magnesium, titanium, halogen and an internal electron donor. The internal electron donor includes an imine compound with a ketone group as shown in Formula I. Disclosed further is a method of preparing the catalyst component, and a catalyst for olefin polymerization containing the catalyst component. When the catalyst is used in olefin polymerization reaction especially propene polymerization reaction, the catalyst has a high long-term activity and good hydrogen response, and the obtained polymer has characteristics of an adjustable isotactic index and a relatively wide molecular weight distribution.

  公开了一种用于烯烃聚合的催化剂组分。催化剂组分包括镁、钛、卤素和内部电子供体。内部电子供体包括如式 I 所示的带有酮基的亚胺化合物。进一步公开的是制备催化剂组分的方法，以及含有该催化剂组分的烯烃聚合催化剂。当催化剂用于烯烃聚合反应，特别是丙烯聚合反应时，催化剂具有较高的长期活性和良好的氢响应，得到的聚合物具有可调节的同素异形指数和相对较宽的分子量分布。