摩熵化学
数据库官网
小程序
打开微信扫一扫
首页 分子通 化学资讯 化学百科 反应查询 关于我们
请输入关键词

11-Methylamino-undecansaeure | 7408-80-2

中文名称
——
中文别名
——
英文名称
11-Methylamino-undecansaeure
英文别名
11-(Methylamino)undecanoic acid
11-Methylamino-undecansaeure化学式
CAS
7408-80-2
化学式
C12H25NO2
mdl
——
分子量
215.336
InChiKey
PPUISJYZMGRCNH-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    0.8
  • 重原子数:
    15
  • 可旋转键数:
    11
  • 环数:
    0.0
  • sp3杂化的碳原子比例:
    0.92
  • 拓扑面积:
    49.3
  • 氢给体数:
    2
  • 氢受体数:
    3

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    描述:
    11-Methylamino-undecansaeure4-二甲氨基吡啶氯化亚砜三乙胺 作用下, 以 二氯甲烷 为溶剂, 生成 Methyl 11-[methyl(prop-2-enoyl)amino]undecanoate
    参考文献:
    名称:
    Polyanion Inhibitors of Human Immunodeficiency Virus and Other Viruses. 5. Telomerized Anionic Surfactants Derived from Amino Acids
    摘要:
    omega-Acryloyl anionic surfactants, whose polar heads are derived from amino acids, have been telomerized to prepare polyanions of a predetermined molecular weight. The main goal of this study was to verify whether the antiviral activity is influenced by the degree of polymerization of the polyanions. The oligomeric polyanions were evaluated for their activity against human immunodeficiency virus (HIV-1 or HIV-2) and various other RNA and DNA viruses. With regard to their anti-HIV activity, a minimum number of anionic groups was necessary to achieve an inhibitory effect. Moreover, to be active the overall conformation of the polyanion must be such that the anionic groups are located on the external site of the molecule. With some of the polyanions, a 50% inhibition concentration (IC50) as low as 1 mu g/mL, or even 0.1 mu g/mL, was noted against HIV-1 in CEM-4 and MT-4 cells, respectively. The most potent polyanions also proved active against human cytomegalovirus and herpex simplex virus at concentrations of 5-10 and 20-40 mu g/mL, respectively. No activity was observed against any of the other viruses tested (i.e., vesicular stomatitis, Sindbis, Semliki forest, parainfluenza, Junin, Tacaribe, Coxsackie, polio, reo, and vaccinia). No toxicity for the host cells was observed at concentrations up to 200 mu g/mL.
    DOI:
    10.1021/jm960493b
  • 作为产物:
    描述:
    11-溴十一酸甲胺甲醇 为溶剂, 反应 18.0h, 生成 11-Methylamino-undecansaeure
    参考文献:
    名称:
    构象受约束的[p-(ω-氨基烷基)苯乙酰基] -L-丝氨酰-L-赖氨酰二肽酰胺,作为白色念珠菌和人类肉豆蔻酰基-CoA:蛋白N-肉豆蔻酰基转移酶的有效拟肽抑制剂
    摘要:
    肉豆蔻酰基CoA:蛋白N-肉豆蔻酰基转移酶(NMT)通过酰胺键将14个碳的饱和肉豆蔻酸脂肪酸酯共价连接到多种细胞蛋白的N末端甘氨酸残基上。遗传研究表明,NMT对于主要真菌病原体的生存至关重要,这些病原体会在免疫抑制的人类中引起系统性感染,因此是开发杀菌药物的目标。我们已经从一种这样的真菌病原体白色念珠菌中产生了一类有效的NMT拟肽抑制剂。将底物类似物抑制剂ALYASKL-NH2的N末端四肽替换为具有最佳11-碳链抑制作用的ω-氨基链烷酰基部分(11-氨基十一烷酰基-SKL-NH2,3a,IC50 = 1.2 +/- 0.14 microM)。C末端Leu的一系列替代物确定含有亲脂性侧链的残基最有效,其中环己基丙氨酸的效价最大(3g,IC50 = 0.36 +/- 0.06 microM)。羧酰胺部分的除去导致含有N-(环己基乙基)赖氨酰胺的代谢稳定的二肽抑制剂(17e,IC 50 = 0.11
    DOI:
    10.1021/jm9608671
点击查看最新优质反应信息

文献信息

  • Conformationally Constrained [<i>p</i>-(ω-Aminoalkyl)phenacetyl]-<scp>l</scp>-seryl-<scp>l</scp>-lysyl Dipeptide Amides as Potent Peptidomimetic Inhibitors of <i>Candida albicans</i> and Human Myristoyl-CoA:Protein <i>N</i>-Myristoyl Transferase
    作者:Srinivasan R. Nagarajan、Balekudru Devadas、Mark E. Zupec、Sandra K. Freeman、David L. Brown、Hwang-Fun Lu、Pramod P. Mehta、Nandini S. Kishore、Charles A. McWherter、Daniel P. Getman、Jeffrey I. Gordon、James A. Sikorski
    DOI:10.1021/jm9608671
    日期:1997.5.1
    inhibitor containing an N-(cyclohexylethyl)lysinamide (17e, IC50 = 0.11 +/- 0.03 microM). Partial rigidification of the flexible aminoundecanoyl chain produced the dipeptide p-(omega-aminohexyl)phenacetyl-L-seryl-L-lysyl-N-(cyclohexyleth yl)amide (26b, IC50 = 0.11 +/- 0.04 microM). Subsequent incorporation of an alpha-methyl substituent into 26b provided the dipeptide analog [2-[p-(omega-aminohexyl)ph
    肉豆蔻酰基CoA:蛋白N-肉豆蔻酰基转移酶(NMT)通过酰胺键将14个碳的饱和肉豆蔻酸脂肪酸酯共价连接到多种细胞蛋白的N末端甘氨酸残基上。遗传研究表明,NMT对于主要真菌病原体的生存至关重要,这些病原体会在免疫抑制的人类中引起系统性感染,因此是开发杀菌药物的目标。我们已经从一种这样的真菌病原体白色念珠菌中产生了一类有效的NMT拟肽抑制剂。将底物类似物抑制剂ALYASKL-NH2的N末端四肽替换为具有最佳11-碳链抑制作用的ω-氨基链烷酰基部分(11-氨基十一烷酰基-SKL-NH2,3a,IC50 = 1.2 +/- 0.14 microM)。C末端Leu的一系列替代物确定含有亲脂性侧链的残基最有效,其中环己基丙氨酸的效价最大(3g,IC50 = 0.36 +/- 0.06 microM)。羧酰胺部分的除去导致含有N-(环己基乙基)赖氨酰胺的代谢稳定的二肽抑制剂(17e,IC 50 = 0.11
  • [EN] SMALL MOLECULE INHIBITORS OF INFLUENZA HEMAGGLUTININ<br/>[FR] INHIBITEURS À PETITES MOLÉCULES DE L'HÉMAGGLUTININE DE LA GRIPPE
    申请人:SCRIPPS RESEARCH INST
    公开号:WO2021202600A1
    公开(公告)日:2021-10-07
    Disclosed are small molecule inhibitors of influenza HA, and methods of using them to treat or prevent HA-mediated diseases and conditions.
    本发明揭示了流感HA的小分子抑制剂,以及使用它们治疗或预防HA介导的疾病和病况的方法。
  • [EN] NATURAL SAPONIN-BASED SYNTHETIC IMMUNOADJUVANTS<br/>[FR] IMMUNO-ADJUVANTS SYNTHÉTIQUES À BASE DE SAPONINE NATURELLE
    申请人:UAB RESEARCH FOUNDATION
    公开号:WO2013142142A1
    公开(公告)日:2013-09-26
    The present disclosure encompasses QS-21-based structurally-defined adjuvants to address the need for stronger, safer, and easier-to-access adjuvants. The new compositions can provide tools for addressing long-standing mechanistic questions concerning saponin immune-potentiation through structure-activity-relationship (SAR) studies. Most advantageously, the compounds of the disclosure may be formulated into pharmaceutically acceptable compositions, including vaccines that may be delivered to a subject human or animal subject. The compounds can then act as, for example, an adjuvant to augment an immunological response to a vaccine immunogen.
    本公开涵盖基于QS-21的结构定义佐剂,以解决更强、更安全、更易获得的佐剂需求。新的组合物可以提供工具来通过结构活性关系(SAR)研究解决长期存在的皂苷免疫激活机制问题。最有优势的是,本公开的化合物可以制成药学上可接受的组合物,包括可以提供给人或动物的疫苗。然后,这些化合物可以作为佐剂,例如增强对疫苗免疫原的免疫反应。
  • Barger et al., Journal of the Chemical Society, 1937, p. 718,720
    作者:Barger et al.
    DOI:——
    日期:——
  • Aelion; Champenter, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1947, vol. 224, p. 347
    作者:Aelion、Champenter
    DOI:——
    日期:——
查看更多