ethyl (1Z)-N-(1H-indole-3-carbonyl)methanehydrazonate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: ethyl (1Z)-N-(1H-indole-3-carbonyl)methanehydrazonate
• 化学式: C₁₂H₁₃N₃O₂
• 分子量: 231.254
• InChiKey: FEPPFDKRMZJQDX-ZSOIEALJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  66.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1H-吲哚-3-羧酸肼 、 原甲酸三乙酯 生成 ethyl (1Z)-N-(1H-indole-3-carbonyl)methanehydrazonate 、 (E)-(ethyl N-[(E)-1H-indole-3-carbonyl]carbohydrazonate)
  参考文献：
  名称：

  Synthesis and functionalization of the 3-(1,3,4-oxadiazol-2-yl)-1h-indoles

  摘要：

  A modified method is proposed for the preparative synthesis of 3-(1,3,4-oxadiazol-2-yl)-1H-indoles in high yield. We are the first to demonstrate the functionalization of this heterocyclic system by alkylation. In particular, syntheses are reported for [3-(1,3,4-oxadiazol-2-yl)-1H-indol-1-yl]acetic acids and their amide derivatives.

  DOI：

  10.1007/s10593-010-0418-0

文献信息

• Synthesis and functionalization of the 3-(1,3,4-oxadiazol-2-yl)-1h-indoles
  作者：S. B. Alyab’ev、D. V. Kravchenko、A. V. Ivashchenko

  DOI：10.1007/s10593-010-0418-0

  日期：2009.10

  A modified method is proposed for the preparative synthesis of 3-(1,3,4-oxadiazol-2-yl)-1H-indoles in high yield. We are the first to demonstrate the functionalization of this heterocyclic system by alkylation. In particular, syntheses are reported for [3-(1,3,4-oxadiazol-2-yl)-1H-indol-1-yl]acetic acids and their amide derivatives.