A novel intracellular signalling activity of coagulation factor VII (FVII) in cells expressing tissue factor (TF) is described. The present invention relates to use of FVIIa or another TF agonist, or FVIIai or another TF antagonist for the preparation of a medicament for modulation of FVIIa-induced activation of the MAPK signalling pathway in a patient. Moreover the present invention relates to a method of treatment, and a method of detecting the activity of compounds, in particular drug candidates, that interact with the FVIIa mediated intracellular signalling pathway.
本发明描述了
凝血因子VII(FVII)在表达组织因子(TF)的细胞中的一种新的细胞内信号传导活性。本发明涉及使用FVIIa或另一个TF激动剂,或FVIIai或另一个TF拮抗剂用于制备用于调节患者中FVIIa诱导的
MAPK信号通路激活的药物。此外,本发明涉及一种治疗方法和一种检测与FVIIa介导的细胞内信号通路相互作用的化合物,特别是药物候选物的活性的方法。