(3S)-3-(2-bromoacetoxy)-1-[2-(3-methoxyphenyl)ethyl]pyrrolidine-2,5-dione | 193154-70-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (3S)-3-(2-bromoacetoxy)-1-[2-(3-methoxyphenyl)ethyl]pyrrolidine-2,5-dione
• 英文别名: [(3S)-1-[2-(3-methoxyphenyl)ethyl]-2,5-dioxopyrrolidin-3-yl] 2-bromoacetate
• CAS: 193154-70-0
• 化学式: C₁₅H₁₆BrNO₅
• 分子量: 370.2
• InChiKey: HDPBAJSCXYUMLW-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  72.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (3S)-3-(2-bromoacetoxy)-1-[2-(3-methoxyphenyl)ethyl]pyrrolidine-2,5-dione 在 三乙胺 、 三苯基膦 作用下， 生成 (S)-4-[2-(3-Methoxy-phenyl)-ethyl]-6,6a-dihydro-4H-furo[3,2-b]pyrrole-2,5-dione
  参考文献：
  名称：

  Asymmetric Synthesis of Furo-Pyrrolo-Isoquinoline and Furo-Indolizino-Indole Derivatives Via A Diastereoselective N-Acyliminium ion Cyclization

  摘要：

  Asymmetric synthesis of furo-pyrrolo-isoquinoline and furo-indolizino-indole derivatives via a diastereoselective N-acyliminium ion cyclization of chiral enamides is described. The requisite chiral enamides were prepared from readily available L-malic acid.

  DOI：

  10.1080/00397919708004155
• 作为产物：
  描述：

  3-甲氧基苯乙胺 在 吡啶 作用下， 以 xylene 为溶剂， 反应 4.5h， 生成 (3S)-3-(2-bromoacetoxy)-1-[2-(3-methoxyphenyl)ethyl]pyrrolidine-2,5-dione
  参考文献：
  名称：

  Asymmetric Synthesis of Furo-Pyrrolo-Isoquinoline and Furo-Indolizino-Indole Derivatives Via A Diastereoselective N-Acyliminium ion Cyclization

  摘要：

  Asymmetric synthesis of furo-pyrrolo-isoquinoline and furo-indolizino-indole derivatives via a diastereoselective N-acyliminium ion cyclization of chiral enamides is described. The requisite chiral enamides were prepared from readily available L-malic acid.

  DOI：

  10.1080/00397919708004155

文献信息

• Asymmetric Synthesis of Furo-Pyrrolo-Isoquinoline and Furo-Indolizino-Indole Derivatives Via A Diastereoselective N-Acyliminium ion Cyclization
  作者：Lee, Yong Sup、Lee, Jae Yeol、Park, Hokoon

  DOI：10.1080/00397919708004155

  日期：1997.8

  Asymmetric synthesis of furo-pyrrolo-isoquinoline and furo-indolizino-indole derivatives via a diastereoselective N-acyliminium ion cyclization of chiral enamides is described. The requisite chiral enamides were prepared from readily available L-malic acid.