1-(4-ethoxy-phenyl)-propan-1-ol | 1031927-88-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-ethoxy-phenyl)-propan-1-ol
• 英文别名: 1-(4-Aethoxy-phenyl)-propan-1-ol；α-Oxy-α-(4-aethoxy-phenyl)-propan；Aethyl-(4-aethoxy-phenyl)-carbinol；α-(4-Aethoxy-phenyl)-propylalkohol；1¹-Oxy-4-aethoxy-1-propyl-benzol；1-(4-Ethoxyphenyl)propan-1-ol
• CAS: 1031927-88-4
• 化学式: C₁₁H₁₆O₂
• 分子量: 180.247
• InChiKey: BJTFSJALTYYMKU-UHFFFAOYSA-N

物化性质

• 沸点：
  287.3±23.0 °C(Predicted)
• 密度：
  1.015±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2909499000

反应信息

• 作为反应物：
  描述：

  1-(4-ethoxy-phenyl)-propan-1-ol 在 草酸 、 potassium carbonate 、 溶剂黄146 作用下， 以 水 、 丙酮 为溶剂， 反应 8.0h， 生成 5-[1-(4-Ethoxy-phenyl)-propyl]-6-methoxy-benzo[1,3]dioxole
  参考文献：
  名称：

  In vivo antitumor activity of 6-benzyl-1,3-benzodioxole derivatives against the P388, L1210, B16, and M5076 murine models

  摘要：

  A series of 6-benzyl-1,3-benzodioxoles have been synthesized and evaluated against the in vivo ip P388 murine lymphocytic leukemia. Selected activities against this system were tested against the additional in vivo systems L1210, B16, M5076, and MX1. The most active of the 6-benzyl-1,3-benzodioxoles tested were as effective as podophyllotoxin as experimental antitumor agents in vivo, but larger doses were required. Three of the P388-active series members were active against the in vitro astrocytoma assay, which detects compounds that interfere with or bind to tubulin.

  DOI：

  10.1021/jm00393a012
• 作为产物：
  描述：

  1-(4-乙氧基苯基)-1-丙酮 在 sodium tetrahydroborate 、 cerium(III) chloride 作用下， 以 甲醇 为溶剂， 生成 1-(4-ethoxy-phenyl)-propan-1-ol
  参考文献：
  名称：

  Etherification of Diarylmethanols and 1-Phenylalkan-1-ols Over Platinum on Carbon

  摘要：

  在碳上铂（Pt/C）的存在下，二芳基甲醇和供体取代的 1-苯基烷-1-醇会与伯醇和仲醇发生交叉醚化反应。

  DOI：

  10.2174/157017809789869564

文献信息

• 1-Phenyl-1-propanol derivatives
  申请人：CHISSO CORPORATION

  公开号：EP0354655A2

  公开（公告）日：1990-02-14

  Optically active compounds suitable for use in liquid crystal compositions, have the formula: in which R¹ and R² are each a hydrogen or halogen atom or an alkyl or alkoxy group containing up to 20 carbon atoms; ℓ, m and n are each 0 or 1; and are independently a group or (in which Y is hydrogen or halogen atom or a cyano group).

  适用于液晶组合物的光学活性化合物具有以下式子： 其中 R¹ 和 R² 分别为氢原子、卤素原子或含有多达 20 个碳原子的烷基或烷氧基；ℓ、m 和 n 分别为 0 或 1；以及 独立为一个基团 或 (其中 Y 为氢原子、卤素原子或氰基）。
• PROCESS FOR PREPARATING OPTICALLY ACTIVE COMPOUNDS
  申请人：Japan Science and Technology Corporation

  公开号：EP0916637A1

  公开（公告）日：1999-05-19

  The present invention relates to a novel, highly practical method for producing optically active compounds such as optically active alcohol and optically active amine useful for various utilities such as synthetic intermediates of drugs, liquid crystal materials, and optical resolution agents, comprising hydrogen transfer-type asymmetric reduction in the presence of a transition metal catalyst and an optically active nitrogen-containing compound or a transition metal catalyst with an optically active nitrogen-containing compound as the asymmetric ligand, and a hydrogen-donating organic or inorganic compound. In accordance with the present invention, characteristically, an optically active secondary alcohol can be recovered through the hydrogen transfer-type oxidation from racemic secondary alcohol or meso-type diol.

  本发明涉及一种生产光学活性化合物（如光学活性醇和光学活性胺）的新型、高度实用的方法，该方法可用于药物合成中间体、液晶材料和光学分辨剂等多种用途，包括在过渡金属催化剂和光学活性含氮化合物或过渡金属催化剂与光学活性含氮化合物作为不对称配体以及供氢有机或无机化合物存在下进行氢转移型不对称还原。 根据本发明，外消旋仲醇或中型二元醇通过氢转移型氧化可回收光学活性仲醇。
• Klages, Chemische Berichte, 1902, vol. 35, p. 2263
  作者：Klages

  DOI：——

  日期：——
• Process for preparing optically active alcohols
  申请人：Japan Science and Technology Agency

  公开号：EP1300381B1

  公开（公告）日：2006-03-08
• SILICON-CONTAINING CONDENSATE, COMPOSITION FOR FORMING A SILICON-CONTAINING RESIST UNDER LAYER FILM, AND PATTERNING PROCESS
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：US20170154766A1

  公开（公告）日：2017-06-01

  The present invention provides a silicon-containing condensate comprising one or more repeating units selected from a repeating unit shown by the following general formula (A1), a repeating unit shown by the following general formula (A2), and a repeating unit shown by the following general formula (A3), wherein R 1 represents a group shown by the following general formula (A-1) or (A-2); R 2 and R 3 each independently represent the same group as R 1 , a hydrogen atom, or a monovalent organic group having 1 to 30 carbon atoms other than R 1 . There can be provided a silicon-containing condensate to give a composition for forming a silicon-containing resist under layer film which can form a resist under layer film with good adhesiveness to any resist pattern, whether the pattern is formed by negative development or positive development.