甲酰基谷氨酸 | 1681-96-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 甲酰基谷氨酸
• 英文名称: N-Formyl-L-glutaminsaeure
• 英文别名: N-formyl-L-glutamic acid；L-2-Formamino-glutarsaeure；N-Formyl-L-glutamic acid；(2S)-2-formamidopentanedioic acid
• CAS: 1681-96-5
• 化学式: C₆H₉NO₅
• 分子量: 175.141
• InChiKey: ADZLWSMFHHHOBV-BYPYZUCNSA-N

物化性质

• 熔点：
  133-135 °C
• 沸点：
  504.8±40.0 °C(Predicted)
• 密度：
  1.419±0.06 g/cm3(Predicted)
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  甲酸 、 L-谷氨酸 在 水 、 乙酸酐 作用下， 生成 甲酰基谷氨酸
  参考文献：
  名称：

  Tabor; Mehler, Journal of Biological Chemistry, 1954, vol. 210, p. 559,565

  摘要：

  DOI：

文献信息

• The Formylation of Amino Acids with Acetic Formic Anhydride
  作者：Ichiro Muramatsu、Masahiro Murakami、Takahiro Yoneda、Akira Hagitani

  DOI：10.1246/bcsj.38.244

  日期：1965.2

  The formylation of amino acids with acetic formic anhydride has been studied. This anhydride is prepared by the reaction of acetyl chloride with sodium formate or, preferably, from ketene and formic acid. When various monoamino monocarboxylic acids are treated with acetic formic anhydride by a simple procedure and under mild conditions, N-formylamino acids were obtained in satisfactory yields.

  已经研究了用乙酸甲酸酐对氨基酸进行甲酰化。该酸酐通过乙酰氯与甲酸钠或优选由乙烯酮和甲酸反应制备。当通过简单的程序和温和的条件用乙酸甲酸酐处理各种单氨基单羧酸时，以令人满意的收率获得了N-甲酰氨基酸。
• Method for producing optical-active cis-piperidine derivatives
  申请人：——

  公开号：US20040171836A1

  公开（公告）日：2004-09-02

  An optical-active cis-piperidine derivative of high chemical purity and high optical purity is efficiently produced through optical resolution of a cis-piperidine derivative mixture, racemic cis-piperidine derivative with an optical-active tartaric acid derivative or an optical-active amino acid derivative. For the optical-active tartaric acid derivative, preferred are optical-active di(paratoluoyl)tartaric acid and optical-active di(4-methoxybenzoyl)tartaric acid; and for the optical-active amino acid derivative, preferred is optical-active N-benzenesulfonylphenylalanine.

  高化学纯度和高光学纯度的光学活性顺式哌啶衍生物可通过对顺式哌啶衍生物混合物进行光学分辨得到，所述混合物包括光学活性酒石酸衍生物或光学活性氨基酸衍生物与混合的顺式哌啶衍生物，所述混合的顺式哌啶衍生物为消旋的。对于光学活性酒石酸衍生物，首选的是光学活性二(对甲苯基)酒石酸和光学活性二(4-甲氧基苯甲酰)酒石酸；对于光学活性氨基酸衍生物，首选的是光学活性N-苯磺酰苯丙氨酸。
• BI-LIGAND DRUG CONJUGATE AND USE THEREOF
  申请人：COHERENT BIOPHARMA (SUZHOU), LIMITED

  公开号：US20220175761A1

  公开（公告）日：2022-06-09

  The present disclosure discloses a conjugate compound or a pharmaceutically acceptable salt thereof, comprising a payload and two targeting molecules. Further disclosed herein is a pharmaceutical composition, comprising the conjugate compound or the pharmaceutically acceptable salt thereof. The present disclosure additionally relates to a method for delivering a payload to a subject in need thereof, and a method for treating a disease, wherein the methods comprise administering to the subject a therapeutically effective amount of the conjugate compound or the pharmaceutically acceptable salt thereof, or the pharmaceutical composition as disclosed herein.

  本公开披露了一种共轭化合物或其药学上可接受的盐，包括一个药物负载和两个靶向分子。此外，本公开还披露了一种制药组合物，包括所述的共轭化合物或其药学上可接受的盐。本公开还涉及一种将药物负载传递给需要的受体的方法，以及一种治疗疾病的方法，其中所述方法包括向受体施用所述共轭化合物或其药学上可接受的盐，或本公开披露的制药组合物的治疗有效量。
• PROCESS FOR PREPARING OPTICALLY ACTIVE 2-PIPERAZINECARBOXYLIC ACID DERIVATIVES
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP0906906A1

  公开（公告）日：1999-04-07

  Optically-active 2-piperazinecarboxylic acid derivatives are produced through diastereomer salt resolution using optically-active acidic amino acid derivative as the resolving reagent. In this method, the recovery of the resolving reagent used is high, and the production efficiency to produce the optically-active products is high. As the optically-active acidic amino acid derivatives, usable are optically-active, N-acylated acidic amino acid derivatives and optically-active, N-sulfonylated acidic amino acid derivatives.

  使用具有光学活性的酸性氨基酸衍生物作为解析试剂，通过非对映异构盐解析法生产出具有光学活性的 2-哌嗪甲酸衍生物。在这种方法中，所用的解析试剂回收率高，生产光学活性产品的效率也高。 光学活性酸性氨基酸衍生物包括光学活性 N-酰化酸性氨基酸衍生物和光学活性 N-磺酰化酸性氨基酸衍生物。
• PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE CIS-PIPERIDINE DERIVATIVES
  申请人：Toray Fine Chemicals Co., Ltd.

  公开号：EP1457487A1

  公开（公告）日：2004-09-15

  An optical-active cis-piperidine derivative of high chemical purity and high optical purity is efficiently produced through optical resolution of a cis-piperidine derivative mixture, racemic cis-piperidine derivative with an optical-active tartaric acid derivative or an optical-active amino acid derivative. For the optical-active tartaric acid derivative, preferred are optical-active di(paratoluoyl)tartaric acid and optical-active di(4-methoxybenzoyl)tartaric acid; and for the optical-active amino acid derivative, preferred is optical-active N-benzenesulfonylphenylalanine.

  通过对顺式哌啶衍生物混合物、外消旋顺式哌啶衍生物与光学活性酒石酸衍生物或光学活性氨基酸衍生物进行光学解析，可高效制得化学纯度和光学纯度都很高的光学活性顺式哌啶衍生物。对于光学活性酒石酸衍生物，优选光学活性二（对羟基苯甲酰基）酒石酸和光学活性二（4-甲氧基苯甲酰基）酒石酸；对于光学活性氨基酸衍生物，优选光学活性 N-苯磺酰基苯丙氨酸。