N-[3,4-dihydro-1,5-benzoxathiepin-3-yl]-3-(R)-[(2-amino-3-methoxyphenyl)thio]-2-(S)-methylpropionamide | 1169760-46-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-[3,4-dihydro-1,5-benzoxathiepin-3-yl]-3-(R)-[(2-amino-3-methoxyphenyl)thio]-2-(S)-methylpropionamide
• 英文别名: (2S)-3-(2-amino-3-methoxyphenyl)sulfanyl-N-[(3R)-3,4-dihydro-2H-1,5-benzoxathiepin-3-yl]-2-methylpropanamide
• CAS: 1169760-46-6
• 化学式: C₂₀H₂₄N₂O₃S₂
• 分子量: 404.554
• InChiKey: FOGXILZSGCUCBV-ZIAGYGMSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  124
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-[3,4-dihydro-1,5-benzoxathiepin-3-yl]-3-(R)-[(2-amino-3-methoxyphenyl)thio]-2-(S)-methylpropionamide 在 sodium tetrahydroborate 、 三氟化硼乙醚 、 盐酸 、 sodium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 生成 3,4-dihydro-N-[(2S)-3-[(2-amino-3-methoxyphenyl)thio]-2-methylpropyl]-2H-(3R)-1,5-benzoxathiepin-3-amine
  参考文献：
  名称：

  Na⁺ Currents in Cardioprotection: Better to Be Late

  摘要：

  We report the discovery of a selective, potent inhibitor of the late current mediated by the cardiac isoform of the sodium channel (Nav 1.5). The compound, 3,4-dihydro-N-[(2S)-3-[(2-hydroxy-3-methylphenyl)thio]-2-methylpropyl]-2H-(3R)-1,5-benzoxathiepin-3-amine (2d) (F 15741), blocks the late component of the Na+ currents and greatly reduces veratridine- or ischemia-induced contracture in isolated tissue and whole heart. The cardioprotective action of 2d was further established in a model of myocardial infarction in the pig in which 2d prevents ischemia-reperfusion damage after 60 min of coronary occlusion and 48 h reperfusion. Under these experimental conditions, only 2d and cariporide reduce infarct size. Remarkably, myocardial protection afforded by 2d occurs in the absence of hemodynamic effects. These data expand the therapeutic potential of late I-Na blockers and suggest that 2d could be useful in pathologies for which pharmacological treatments are not yet available.

  DOI：

  10.1021/jm900296e
• 作为产物：
  描述：

  N-[3,4-dihydro-1,5-benzoxathiepin-3-yl]-(R)-3-methanesulfonyloxy-2-(R)-methyl-propionamide 、 2-氨基-3-甲氧基苯硫酚 在 三苯基膦 、 potassium carbonate 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 0.5h， 以29%的产率得到N-[3,4-dihydro-1,5-benzoxathiepin-3-yl]-3-(R)-[(2-amino-3-methoxyphenyl)thio]-2-(S)-methylpropionamide
  参考文献：
  名称：

  Na⁺ Currents in Cardioprotection: Better to Be Late

  摘要：

  We report the discovery of a selective, potent inhibitor of the late current mediated by the cardiac isoform of the sodium channel (Nav 1.5). The compound, 3,4-dihydro-N-[(2S)-3-[(2-hydroxy-3-methylphenyl)thio]-2-methylpropyl]-2H-(3R)-1,5-benzoxathiepin-3-amine (2d) (F 15741), blocks the late component of the Na+ currents and greatly reduces veratridine- or ischemia-induced contracture in isolated tissue and whole heart. The cardioprotective action of 2d was further established in a model of myocardial infarction in the pig in which 2d prevents ischemia-reperfusion damage after 60 min of coronary occlusion and 48 h reperfusion. Under these experimental conditions, only 2d and cariporide reduce infarct size. Remarkably, myocardial protection afforded by 2d occurs in the absence of hemodynamic effects. These data expand the therapeutic potential of late I-Na blockers and suggest that 2d could be useful in pathologies for which pharmacological treatments are not yet available.

  DOI：

  10.1021/jm900296e