Ethyl 2-[4-(2-trifluoromethylphenoxy)phenyl]-3H-benzimidazole-5-carboxylate | 1123819-13-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: Ethyl 2-[4-(2-trifluoromethylphenoxy)phenyl]-3H-benzimidazole-5-carboxylate
• 英文别名: ethyl 2-[4-[2-(trifluoromethyl)phenoxy]phenyl]-3H-benzimidazole-5-carboxylate
• CAS: 1123819-13-5
• 化学式: C₂₃H₁₇F₃N₂O₃
• 分子量: 426.395
• InChiKey: IYHMWINMQKBNDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  64.2
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  在 sodium metabisulfite 、 水 、 溶剂黄146 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.5h， 生成 Ethyl 2-[4-(2-trifluoromethylphenoxy)phenyl]-3H-benzimidazole-5-carboxylate
  参考文献：
  名称：

  Benzimidazole-carboxamides as potent and bioavailable stearoyl-CoA desaturase (SCD1) inhibitors from ligand-based virtual screening and chemical optimization

  摘要：

  The discovery of potent benzimidazole stearoyl-CoA desaturase (SCD1) inhibitors by ligand-based virtual screening is described. ROCS 3D-searching gave a favorable chemical motif that was subsequently optimized to arrive at a chemical series of potent and promising SCD1 inhibitors. In particular, compound SAR224 was selected for further pharmacological profiling based on favorable in vitro data. After oral administration to male ZDF rats, this compound significantly decreased the serum fatty acid desaturation index, thus providing conclusive evidence for SCD1 inhibition in vivo by SAR224. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.01.030

文献信息

• AZOLOARINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICALS CONTAINING THESE COMPOUNDS AND THE USE THEREOF
  申请人：ZOLLER Gerhard

  公开号：US20100240580A1

  公开（公告）日：2010-09-23

  The invention relates to azoloarine derivatives of formula I wherein R, A, B, D, Y, X, M and W are as defined herein, and their physiologically tolerated salts.

  本发明涉及公式I的氮杂芴衍生物，其中R，A，B，D，Y，X，M和W的定义如本文所述，并且其生理上耐受的盐。