N-[2-(二甲氨基)乙基]十四烷酰胺 | 86310-55-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: N-[2-(二甲氨基)乙基]十四烷酰胺
• 英文名称: N-(2-N',N'-dimethylaminoethyl)tetradecanamide
• 英文别名: N-(2-(dimethylamino)ethyl)myristylamide；N-[2-(Dimethylamino)ethyl]tetradecanamide
• CAS: 86310-55-6
• 化学式: C₁₈H₃₈N₂O
• 分子量: 298.513
• InChiKey: VJDHPVULCJEXHP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  21
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-[2-(二甲氨基)乙基]十四烷酰胺 、 chlorhydrate de la 5-(chloromethyl)-2,2,8-trimethyl-4H-1,3-dioxino<4,5-c>pyridine 在 碳酸氢钠 作用下， 以 乙醇 为溶剂， 反应 8.0h， 以53%的产率得到5-(methylene(N,N-dimethyl-N-(2-myristoylaminoethyl)ammonium))-2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin chloride
  参考文献：
  名称：

  基于吡ido醇和脂肪酸的新型季铵化合物的设计，合成，抗菌活性和毒性

  摘要：

  设计了一系列基于季铵吡ido醇衍生物的43种新颖的“软抗菌剂”，其中包括吡soft醇的六元缩醛和缩酮，它们通过可裂解的连接基部分（酰胺，酯）与脂肪羧酸的片段结合。九种化合物对革兰氏阳性和革兰氏阴性细菌菌株具有体外有望的抗菌活性，其MIC值可与参考防腐剂miramistin，苯扎氯铵和氯己定相比。在各种临床分离株上，先导化合物6i和12a表现出与苯扎氯铵相当的抗菌活性，但比miramistin高。此外，6i和12a能够杀死嵌入单物种和双物种生物膜基质中的细菌。用6i和12a处理细菌细胞会导致膜快速去极化，表明该膜是化合物的明显分子靶标。6i和12a在SOS-chromotest和Ames试验中均无致突变性，并且在小鼠急性口服（LD 50 > 2000 mg / kg）和经皮给药（LD 50 > 2500 mg / kg）时体内无毒。综上所述，我们的数据可以表明所描述的活性化合物是新抗菌剂开发的有希望的起点。

  DOI：

  10.1016/j.ejmech.2020.113100
• 作为产物：
  描述：

  肉豆蔻酸 、 N,N-二甲基乙二胺 以 甲苯 为溶剂， 反应 48.0h， 以69%的产率得到N-[2-(二甲氨基)乙基]十四烷酰胺
  参考文献：
  名称：

  基于吡ido醇和脂肪酸的新型季铵化合物的设计，合成，抗菌活性和毒性

  摘要：

  设计了一系列基于季铵吡ido醇衍生物的43种新颖的“软抗菌剂”，其中包括吡soft醇的六元缩醛和缩酮，它们通过可裂解的连接基部分（酰胺，酯）与脂肪羧酸的片段结合。九种化合物对革兰氏阳性和革兰氏阴性细菌菌株具有体外有望的抗菌活性，其MIC值可与参考防腐剂miramistin，苯扎氯铵和氯己定相比。在各种临床分离株上，先导化合物6i和12a表现出与苯扎氯铵相当的抗菌活性，但比miramistin高。此外，6i和12a能够杀死嵌入单物种和双物种生物膜基质中的细菌。用6i和12a处理细菌细胞会导致膜快速去极化，表明该膜是化合物的明显分子靶标。6i和12a在SOS-chromotest和Ames试验中均无致突变性，并且在小鼠急性口服（LD 50 > 2000 mg / kg）和经皮给药（LD 50 > 2500 mg / kg）时体内无毒。综上所述，我们的数据可以表明所描述的活性化合物是新抗菌剂开发的有希望的起点。

  DOI：

  10.1016/j.ejmech.2020.113100

文献信息

• Carboxamide derivative, processes for producing the same, and detergent composition
  申请人：Yajima Toshio

  公开号：US20070010680A1

  公开（公告）日：2007-01-11

  To provide: a carboxamide derivative having reduced content of amide ester; a method for producing thereof; and a detergent composition containing the carboxamide derivative and having excellent low-temperature stability. One method for producing a carboxamide derivative is to react carboxamide, produced with a manufacturing method of carboxamide including 0.02% by weight to 0.18% by weight of amide ester, with hydrogen peroxide, wherein the method includes a carboxamide synthesis process to synthesize carboxamide by reacting diamine with fatty acid ester at a molar rate of 1.20 to 1.60. Another method for producing a carboxamide derivative is to react the carboxamide with monohaloalkylcarboxylic acid or a salt thereof. A carboxamide derivative is produced by the method for producing a carboxamide derivative. A detergent composition includes the carboxamide derivative. The carboxamide derivative is preferably amidoamine oxide or amide betaine.

  提供一种具有减少酰胺酯含量的羧酰胺衍生物；一种生产该衍生物的方法；以及含有该羧酰胺衍生物并具有优异低温稳定性的洗涤剂组合物。一种生产羧酰胺衍生物的方法是将羧酰胺（由含有0.02重量％至0.18重量％酰胺酯的羧酰胺制造方法制备而成）与过氧化氢反应，其中该方法包括羧酰胺合成过程，通过将二胺与脂肪酸酯以摩尔比1.20至1.60反应合成羧酰胺。另一种生产羧酰胺衍生物的方法是将羧酰胺与单卤代烷基羧酸或其盐反应。通过生产羧酰胺衍生物的方法生产羧酰胺衍生物。洗涤剂组合物包括羧酰胺衍生物。该羧酰胺衍生物最好是酰胺胺氧化物或酰胺甜菜碱。
• Comparison of the gelation behaviour of N-substituted tetradecanamide amphiphiles in organic liquids: effect of hydrogen-bonding ability of the head-group
  作者：Amrita Pal、Rita Das Mahapatra、Joykrishna Dey

  DOI：10.1039/c3ra46673f

  日期：——

  In this work, we have investigated the role of intermolecular hydrogen-bonding (H-bonding) interaction of the head-groups of amphiphilic organogelators. For this we have designed, synthesized and studied the gelation behaviour of a series of amide amphiphiles having hydrocarbon chains with the same length (C14) but with –COOH, –OH, –NH2 or –N(CH3)2) functionalities as head-group. These gelators, except the one with –N(CH3)2 head-group, efficiently gelated aromatic solvents. The gelation in all the solvents employed was observed to be thermoreversible. The gels were characterized by XRD spectroscopy, electron microscopy, and rheology. The amphiphiles were observed to form ribbon-like aggregates in aromatic solvents. The gel-to-sol transition temperatures as well as mechanical strengths of the organogels were observed to increase with the spacer length. The results suggest that the intermolecular H-bonding interactions between head-groups were essential for gelation.

  在这项工作中，我们研究了两亲有机凝胶剂头基团分子间氢键（H-bonding）相互作用的作用。为此，我们设计、合成并研究了一系列具有相同长度（C14）烃链但头基具有 -COOH、-OH、-NH2 或 -N(CH3)2）官能团的酰胺两性化合物的凝胶行为。这些凝胶剂（头基为-N(CH3)2 的凝胶剂除外）可有效凝胶芳香族溶剂。据观察，在所有溶剂中的凝胶化都是热可逆的。凝胶通过 XRD 光谱、电子显微镜和流变学进行了表征。据观察，两亲化合物在芳香族溶剂中形成了带状聚集体。据观察，凝胶到溶胶的转变温度以及有机凝胶的机械强度随间隔物长度的增加而增加。结果表明，头基间的分子间 H 键相互作用对凝胶化至关重要。
• Method of improving the electrical conductivity of a molding artcile of resin, method of coating a molding article of resin, and coating composition
  申请人：NIPPON PAINT CO., LTD.

  公开号：EP0764663A2

  公开（公告）日：1997-03-26

  There is provided a method for coating a molded resin article such as an automotive part, and improving its electrical conductivity by a high productivity procedure which avoids using an inorganic conductive primer. The substrate is coated with a composition containing a film-forming component and a specified nitrogen-containing compound and the coated surface is subjected to corona discharge treatment and is then optionally electrostatically coated.

  本发明提供了一种涂覆模塑树脂制品（如汽车零件）的方法，该方法采用高生产率程序，避免使用无机导电底漆，从而提高了其导电性。在基材上涂覆一种含有成膜成分和特定含氮化合物的组合物，然后对涂覆表面进行电晕放电处理，再选择性地进行静电涂覆。
• HAIR GROOMING PREPARATION
  申请人：SHISEIDO COMPANY LIMITED

  公开号：EP1295591A1

  公开（公告）日：2003-03-26

  A hair treatment agent composition characteristically comprising a specific hydrophobically modified polyether urethane and cationic surfactant. The hair treatment agent composition of the present invention provides has good temperature stability in terms of the viscosity, exhibits superior fluid flow characteristics, achieves smoothness and ease of arranging the hair after drying, and gives a superior sensation during use. A cleaning agent composition characteristically comprising a specific hydrophobically modified polyether urethane and anionic surfactant and/or ampholytic surfactant. The cleaning agent composition of the present invention has superior viscosity and is superior in terms of foam formation as well as foam durability and feels refreshing without a slimy sensation after rinsing-off.

  一种头发处理剂组合物，主要由特定的疏水改性聚醚聚氨酯和阳离子表面活性剂组成。 本发明的头发处理剂组合物的粘度具有良好的温度稳定性，表现出优异的流体流动特性，干燥后头发顺滑，易于整理，使用时感觉良好。 一种清洁剂组合物，主要由特定的疏水改性聚醚聚氨酯和阴离子表面活性剂和/或两性表面活性剂组成。 本发明的清洁剂组合物具有极佳的粘度，在泡沫形成和泡沫持久性方面都更胜一筹，冲洗后感觉清爽，无粘腻感。
• Hair cosmetic composition
  申请人：KAO CORPORATION

  公开号：EP1754516A2

  公开（公告）日：2007-02-21

  Provided is a hair cosmetic composition containing Components (A) to (C), and having a pH (at 25°C) of from 1 to 5.5 when diluted to 20 times its weight with water: (A) a cationic surfactant, or a tertiary amine represented by the formula (1): (wherein, at least one of R1 to R3 represents a C8-23 aliphatic hydrocarbon and the remainder represents H, C1-6 alkyl or hydroxyalkyl, or benzyl, R4 represents a C1-6 alkylene, A represents -CONH- or -NHCO-, and a stands for 0 or 1), (B) a C8-30 aliphatic alcohol, and (C) toluenesulfonic acid or salt thereof. The hair cosmetic composition is excellent in the effect of restoring the flyaway or waved hair, which has appeared as a result of accumulation of damage due to hair coloring or the like, to its former state before damage and can give the hair good flexibility and smoothness during use of it.

  本发明提供了一种头发化妆品组合物，该组合物含有成分(A)至(C)，当用水稀释至其重量的20倍时，pH值(25℃)为1至5.5： (A) 阳离子表面活性剂，或由式（1）代表的叔胺： (其中，R1 至 R3 中至少有一个代表 C8-23 脂肪族烃，其余代表 H、C1-6 烷基或羟基烷基或苄基，R4 代表 C1-6 亚烷基，A 代表 -CONH- 或 -NHCO-，a 代表 0 或 1)、 (B) C8-30 脂肪醇，和 (C) 甲苯磺酸或其盐。 本发明的头发化妆品组合物具有极佳的效果，可将因染发或类似原因造成的损伤累积而出现的飞扬或波浪状头发恢复到损伤前的状态，并能在使用过程中赋予头发良好的柔韧性和顺滑度。