2-[(16-benzyloxyhexadec-1-yl)oxy]tetrahydro-2H-pyran | 1528740-48-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(16-benzyloxyhexadec-1-yl)oxy]tetrahydro-2H-pyran
• CAS: 1528740-48-8
• 化学式: C₂₈H₄₈O₃
• 分子量: 432.687
• InChiKey: IQBXOJPPQSIGMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.21
• 重原子数：
  31.0
• 可旋转键数：
  20.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  27.69
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  2-[(16-benzyloxyhexadec-1-yl)oxy]tetrahydro-2H-pyran 在 水 、 溴 、 4-甲基苯磺酸吡啶 、 magnesium 、 三乙胺 、 三苯基膦 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 氯仿 为溶剂， 反应 9.0h， 生成
  参考文献：
  名称：

  Synthesis of Novel Asymmetrical Single-Chain Phosphoglycol-Based Bolaamphiphiles

  摘要：

  The synthesis of long-chain 1,-diols with orthogonal cleavable protecting groups can be effectively performed with the use of the Grignard coupling reaction, successfully leading to the preparation of novel asymmetrical single-chain phosphoglycol-based bolaamphiphilesa side-product that always occurred during the synthesis of symmetrical bolalipids. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) for the following free supplemental resource(s): Full experimental and spectral details.]

  DOI：

  10.1080/00397911.2013.825806
• 作为产物：
  描述：

  2-((16-bromohexadecyl)oxy)tetrahydro-2H-pyran 、 苯甲醇 在 sodium hydride 、 n-tetrabutylammonium iodide 作用下， 以 甲苯 、 paraffin oil 为溶剂， 反应 38.0h， 以70%的产率得到2-[(16-benzyloxyhexadec-1-yl)oxy]tetrahydro-2H-pyran
  参考文献：
  名称：

  Synthesis of Novel Asymmetrical Single-Chain Phosphoglycol-Based Bolaamphiphiles

  摘要：

  The synthesis of long-chain 1,-diols with orthogonal cleavable protecting groups can be effectively performed with the use of the Grignard coupling reaction, successfully leading to the preparation of novel asymmetrical single-chain phosphoglycol-based bolaamphiphilesa side-product that always occurred during the synthesis of symmetrical bolalipids. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) for the following free supplemental resource(s): Full experimental and spectral details.]

  DOI：

  10.1080/00397911.2013.825806