天冬氨酸乙酯 | 21860-85-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 天冬氨酸乙酯
• 英文名称: 2-amino-succinic acid 4-ethyl ester
• 英文别名: dl-aspartic acid-1-ethyl ester；DL-Asparaginsaeure-1-aethylester；dl-Asparaginsaeure-α-monoaethylester；aspartic acid ethyl ester；3-Amino-4-ethoxy-4-oxobutanoic acid
• CAS: 21860-85-5
• 化学式: C₆H₁₁NO₄
• mdl: MFCD06206006
• 分子量: 161.158
• InChiKey: WXFCDLWCQIARFW-UHFFFAOYSA-N

物化性质

• 熔点：
  164-165 °C (decomp)
• 沸点：
  97-98 °C(Press: 1 Torr)
• 密度：
  1.242±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.2
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  89.6
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 海关编码：
  2922509090

反应信息

• 作为反应物：
  描述：

  天冬氨酸乙酯 、 氨 生成 3,4-二氨基-4-氧代丁酸
  参考文献：
  名称：

  Piutti, Gazzetta Chimica Italiana, 1888, vol. 18, p. 471,478

  摘要：

  DOI：
• 作为产物：
  描述：

  Diethyl 2-(Hydroxyimino)succinate 在 乙醇 、 硫酸 、 sodium 作用下， 生成 天冬氨酸乙酯
  参考文献：
  名称：

  Piutti, Gazzetta Chimica Italiana, 1888, vol. 18, p. 471,478

  摘要：

  DOI：

文献信息

• COMPOUNDS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH THE FORMATION OF AMYLOID FIBRILS
  申请人：Innovaprotean, S.L.

  公开号：EP1679299A1

  公开（公告）日：2006-07-12

  SUMMARY The present invention provides new amyloidogenesis inhibiting compounds of formula (I): in which R1 is a -NRaRb group, where Ra and Rb, independently, are a hydrogen atom or a C1-C6 alkyl group; -ORc group, where Rc is a hydrogen atom or a C1-C6 alkyl group; a glycosyl; a C1-C6 polyhydroxyalkyl; or a -NH-CH(Rd)-COORe group, where Rd is a side chain of one of the 20 natural alpha-amino acids in either of their two enantiomerically pure forms L or D, and Re is a hydrogen atom or a C1-C6 alkyl group; and R2 is a hydrogen atom, a C1-C6 alkyl group, a glycosyl; a C1-C6 polyhydroxyalkyl; -C(=O)-Rf group, where Rf is a C1-C6 alkyl group; or a -CH2-COO-Rg group, where Rg is a hydrogen atom or a C1-C6 alkyl group; and pharmaceutically acceptable salts thereof, which are useful in the treatment of neurodegenerative diseases, among others.

  本发明提供了新的抑制淀粉样生成的化合物，其化学式为（I）：其中R1是一个-NRaRb基团，其中Ra和Rb独立地是氢原子或C1-C6烷基基团；-ORc基团，其中Rc是氢原子或C1-C6烷基基团；一种糖基；一种C1-C6多羟基烷基；或者一个-NH-CH（Rd）-COORe基团，其中Rd是20种天然α-氨基酸之一的侧链，以其两种对映纯形式L或D之一存在，Re是氢原子或C1-C6烷基基团；和R2是氢原子，C1-C6烷基基团，糖基；C1-C6多羟基烷基；-C（=O）-Rf基团，其中Rf是C1-C6烷基基团；或者-CH2-COO-Rg基团，其中Rg是氢原子或C1-C6烷基基团；以及其药学上可接受的盐，这些化合物在治疗神经退行性疾病等方面是有用的。
• Rheology control agents
  申请人：Lenges Peter Christian

  公开号：US20060155146A1

  公开（公告）日：2006-07-13

  The present invention provides for a rheology control agent that includes a following compound represented by the following formula: wherein A, B, C and D equal CH 2 , CHR, NH, or O, and A, B, C and D may be the same or different and at least one of A and B equals NH and at least one of C and D equals NH; and wherein R 1 , R 2 , and R 3 may be the same or different and represent a linear, branched, hyper-branched, or dendritic ether, polyether or hydrocarbon based chain, optionally forming at least one carbon-based ring, being saturated or unsaturated and R 2 represents linear or branched alkylenes, ethers, polyethers, or polyester linkages and at least one of R 1 , R 2 , and R 3 comprises an ester group or an amide group which is branched off from the main chain; excluded from Formula (1) is a compound wherein R 2 is CH 2 —CH 2 —CH 2 —CH 2 —CH(C(O)OCH 3 ), A, B, C, and D are equal to NH and R 1 and R 3 are both equal to a linear octyl hydrocarbon chain; the rheology control agent is suitable for solvent-borne and water-borne coating composition having improved rheology control useful for OEM refinishing or repainting the exterior of automobile and truck bodies and parts thereof.

  本发明提供了一种流变控制剂，包括下式所示的化合物：其中A、B、C和D等于CH2、CHR、NH或O，A、B、C和D可以相同也可以不同，且至少有一个A和B等于NH，至少有一个C和D等于NH；R1、R2和R3可以相同也可以不同，表示线性、支链、超支链或树枝状醚、聚醚或碳氢基链，可选地形成至少一个碳基环，饱和或不饱和，其中R2表示线性或支链烷基、醚、聚醚或聚酯键合，且R1、R2和R3中至少有一个包括从主链上分支出的酯基或酰胺基；式（1）中不包括R2为CH2—CH2—CH2—CH2—CH(C(O)OCH3)、A、B、C和D均等于NH，且R1和R3均等于线性辛基碳氢链的化合物；该流变控制剂适用于改善流变控制的溶剂型和水性涂料组合物，可用于汽车和卡车车身及其零部件的OEM翻新或重新涂装。
• N-transfer reagent and method for preparing the same and its application
  申请人：NATIONAL CHENG KUNG UNIVERSITY

  公开号：US11040939B1

  公开（公告）日：2021-06-22

  Provided are a novel N-transfer reagent and a method for preparing the same and its application. The N-transfer reagent is represented by the following Formula (I): The various novel N-transfer reagents of the present invention can be quickly prepared by employing different nitrobenzene precursors. The N-transfer reagents can directly convert a variety of amino compounds into diazo compounds under mild conditions. Particularly, the N-transfer reagents can facilitate the synthesis of the diazo compounds. The application of synthesizing diazo compounds of the present invention can greatly decrease the difficulty in operation, increase the safety during experiments, reduce the cost of production and the environmental pollution, and enhance the industrial value of diazo compounds.

  提供了一种新颖的N-转移试剂及其制备方法和应用。N-转移试剂由以下式（I）表示：本发明的各种新颖N-转移试剂可以通过采用不同的硝基苯前体快速制备。在温和条件下，N-转移试剂可以直接将各种氨基化合物转化为重氮化合物。特别地，N-转移试剂可以促进重氮化合物的合成。本发明用于合成重氮化合物的应用可以大大降低操作难度，增加实验安全性，减少生产成本和环境污染，提高重氮化合物的工业价值。
• SWITCHING FLUORESCENT NANOPARTICLE PROBE AND FLUORESCENT PARTICLE IMAGING METHOD USING SAME
  申请人：Hara Isao

  公开号：US20130149252A1

  公开（公告）日：2013-06-13

  The present invention provides a novel fluorescent nanoparticle imaging probe having a switching function (a function to quench a fluorescent dye during nanoparticle preparation, and emit fluorescence during imaging). A switching fluorescent nanoparticle probe comprising: a molecular assembly composed of an amphiphilic block polymer having a hydrophilic block chain and a hydrophobic block chain; and a fluorescent dye encapsulated in the molecular assembly, wherein (a) the hydrophilic block chain comprises, as an essential hydrophilic structural unit, a unit selected from a sarcosine unit and an alkylene oxide unit, (b) the hydrophobic block chain comprises, as an essential hydrophobic structural unit, a unit selected from the group consisting of an amino acid unit and a hydroxylic acid unit, and (c) the fluorescent dye is a cyanine compound represented by the formula (I): and two or more molecules of the fluorescent dye are encapsulated in the single molecular assembly.

  本发明提供一种新型荧光纳米颗粒成像探针，具有切换功能（在纳米颗粒制备过程中熄灭荧光染料，并在成像过程中发射荧光）。一种切换荧光纳米颗粒探针包括：由具有亲水性块链和疏水性块链的两性块聚合物组成的分子组装体；以及封装在分子组装体中的荧光染料，其中（a）亲水性块链包括作为必要亲水性结构单元的一种选自肌氨酸单元和烷氧基单元的单元，（b）疏水性块链包括作为必要疏水性结构单元的一种选自氨基酸单元和羟基酸单元的单元，（c）荧光染料是由式（I）表示的青菁化合物：并且两个或更多分子的荧光染料被封装在单个分子组装体中。
• NOVEL MOLECULAR ASSEMBLY, MOLECULAR PROBE FOR MOLECULAR IMAGING AND MOLECULAR PROBE FOR DRUG DELIVERY SYSTEM USING THE SAME, AND MOLECULAR IMAGING SYSTEM AND DRUG DELIVERY SYSTEM
  申请人：SHIMADZU CORPORATION

  公开号：US20190105412A1

  公开（公告）日：2019-04-11

  The present invention provides a molecular assembly which is less likely to accumulate in tissue other than cancer tissue, is highly safe for a living body, and can be prepared by a simple and safe method and whose particle size can be easily controlled. The present invention provides a molecular imaging system and a molecular probe useful for the system, and a drug delivery system and a molecular probe useful for the system. The present invention provides a method for preparing molecular assembly, by which the particle size of molecular assembly having a signal group or a drug can be arbitrarily controlled in order to allow the molecular assembly to effectively accumulate in cancer tissue by utilizing EPR effect. A molecular assembly comprising: an amphiphilic block polymer A comprising a hydrophilic block chain and a hydrophobic block chain having 10 or more lactic acid units; a hydrophobic polymer A2 having at least 10 or more lactic acid units; and/or a labeled polymer B comprising at least 10 or more lactic acid units and a labeling group.

  本发明提供了一种分子组装体，其不太可能在癌组织以外的组织中积累，对生物体高度安全，并且可以通过简单安全的方法制备，其粒子大小可以轻松控制。本发明提供了一种分子成像系统和用于该系统的分子探针，以及用于该系统的药物递送系统和分子探针。本发明提供了一种制备分子组装体的方法，通过该方法可以任意控制具有信号基团或药物的分子组装体的粒子大小，以利用EPR效应使分子组装体有效地积累在癌组织中。一种分子组装体，包括：一种含有10个或更多乳酸单元的亲水性块链和疏水性块链的两亲性块聚物A；一种含有至少10个或更多乳酸单元的疏水性聚合物A2；和/或一种标记聚合物B，包括至少10个或更多乳酸单元和一个标记基团。