tert-butyl-4-(2,7-dibromo-9-methyl-9H-fluoren-9-yl)butylcarbamate | 1315468-14-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl-4-(2,7-dibromo-9-methyl-9H-fluoren-9-yl)butylcarbamate
• 英文别名: tert-butyl N-[4-(2,7-dibromo-9-methylfluoren-9-yl)butyl]carbamate
• CAS: 1315468-14-4
• 化学式: C₂₃H₂₇Br₂NO₂
• 分子量: 509.281
• InChiKey: UPOGZBYMCHUMQY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,7-dibromo-9-methylfluorene 在 盐酸 、 KOH 、 一水合肼 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 、 水 、 二甲基亚砜 为溶剂， 生成 tert-butyl-4-(2,7-dibromo-9-methyl-9H-fluoren-9-yl)butylcarbamate
  参考文献：
  名称：

  Novel reagents for directed biomarker signal amplification

  摘要：

  本文描述了涉及中性共轭聚合物的方法、组合物和制造物品，包括合成具有连接物的中性共轭水溶性聚合物的方法，连接物沿聚合物主链结构和末端封端单元。这种聚合物可用于制备新型光电子器件，并在高效生物传感器的开发中发挥作用。该发明进一步涉及这些聚合物在测定方法中的应用。

  公开号：

  US20110256549A1

文献信息

• Novel Reagents for Directed Biomarker Signal Amplification
  申请人：Gaylord Brent S.

  公开号：US20110257374A1

  公开（公告）日：2011-10-20

  Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.

  本文描述了涉及中性共轭聚合物的方法、组合物和制造品，包括合成带有连接物的中性共轭水溶性聚合物的方法，以及端基封闭单元。这些聚合物可用于制造新型光电器件，以及开发高效的生物传感器。本发明进一步涉及这些聚合物在测定方法中的应用。
• Reagents for directed biomarker signal amplification
  申请人：Gaylord Brent S.

  公开号：US08362193B2

  公开（公告）日：2013-01-29

  Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.

  本文描述了涉及中性共轭聚合物的方法、组合物和制造品，包括合成带有连接物的中性共轭水溶性聚合物的方法，以及端基覆盖单元。这种聚合物可以用于制造新型光电器件和高效生物传感器的开发。本发明还涉及这些聚合物在测定方法中的应用。
• NOVEL REAGENTS FOR DIRECTED BIOMARKER SIGNAL AMPLIFICATION
  申请人：Sirigen II Limited

  公开号：EP3981819A2

  公开（公告）日：2022-04-13

  Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.

  本文描述的是涉及中性共轭聚合物的方法、组合物和制造品，包括合成中性共轭水溶性聚合物的方法，该聚合物沿聚合物主链结构具有连接体和末端封端单元。这种聚合物可用于制造新型光电器件和开发高效生物传感器。本发明还涉及这些聚合物在检测方法中的应用。
• Reagents for direct biomarker signal amplification
  申请人：SIRIGEN II LIMITED

  公开号：US10955417B2

  公开（公告）日：2021-03-23

  Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.

  本文描述的是涉及中性共轭聚合物的方法、组合物和制造品，包括合成中性共轭水溶性聚合物的方法，该聚合物沿聚合物主链结构具有连接体和末端封端单元。这种聚合物可用于制造新型光电器件和开发高效生物传感器。本发明还涉及这些聚合物在检测方法中的应用。
• Water‐Soluble Fluorescent Polymer Dyes with Tunable Emission Spectra for Flow Cytometry Applications
  作者：Daniel Berndt、Dorina Glaap、Travis Jennings、Christian Dose、Daniel B. Werz、Dirk N. H. Reckert

  DOI：10.1002/anie.202402616

  日期：——

  A series of water-soluble fluorescent polymer dyes was developed. All π-conjugated polymers are excited by a 405 nm laser, but are distinguishable by their emission spectra. The emission can be tuned by covalently binding of small-molecule dyes (Förster resonance energy transfer). The dyes were bioconjugated to antibodies and used as reagents for multiparameter flow cytometric analysis.

  开发了一系列水溶性高分子荧光染料。所有 π 共轭聚合物均由 405 nm 激光激发，但可通过其发射光谱进行区分。可以通过小分子染料的共价结合（福斯特共振能量转移）来调节发射。将染料与抗体生物缀合并用作多参数流式细胞术分析的试剂。