(2,4-Dimethoxy-benzyl)-(2-methoxy-3-piperidin-1-yl-quinoxalin-6-yl)-amine | 862123-60-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: (2,4-Dimethoxy-benzyl)-(2-methoxy-3-piperidin-1-yl-quinoxalin-6-yl)-amine
• 英文别名: N-[(2,4-dimethoxyphenyl)methyl]-2-methoxy-3-piperidin-1-ylquinoxalin-6-amine
• CAS: 862123-60-2
• 化学式: C₂₃H₂₈N₄O₃
• 分子量: 408.5
• InChiKey: YGYSUTAFWLYIOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  68.7
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (2,4-Dimethoxy-benzyl)-(2-methoxy-3-piperidin-1-yl-quinoxalin-6-yl)-amine 、 苯甲酰氯 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 以84%的产率得到N-(2,4-Dimethoxy-benzyl)-N-(2-methoxy-3-piperidin-1-yl-quinoxalin-6-yl)-benzamide
  参考文献：
  名称：

  Solid-phase synthesis of quinoxaline derivatives using 6-amino-2,3-dichloroquinoxaline loaded on AMEBA resin

  摘要：

  The solid-phase synthesis of quinoxaline derivatives 1 was accomplished through successive introduction of building blocks such as amines. methoxide, acid chlorides, and isocyanates into 6-amimo-2,3-dichloroquinoxaline 2 loaded on AMEBA resin 3. The method made it possible to obtain the compound 1 in 63-100% purities and 36-89% isolated yields. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.05.096
• 作为产物：
  描述：

  2,3-二氯-6-硝基喹啉 在 palladium on activated charcoal 盐酸 、 氢气 、 三乙酰氧基硼氢化钠 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 1,2-二氯乙烷 、 N,N-二甲基甲酰胺 为溶剂， 20.0~50.0 ℃ 、275.79 kPa 条件下， 反应 40.0h， 生成 (2,4-Dimethoxy-benzyl)-(2-methoxy-3-piperidin-1-yl-quinoxalin-6-yl)-amine
  参考文献：
  名称：

  Solid-phase synthesis of quinoxaline derivatives using 6-amino-2,3-dichloroquinoxaline loaded on AMEBA resin

  摘要：

  The solid-phase synthesis of quinoxaline derivatives 1 was accomplished through successive introduction of building blocks such as amines. methoxide, acid chlorides, and isocyanates into 6-amimo-2,3-dichloroquinoxaline 2 loaded on AMEBA resin 3. The method made it possible to obtain the compound 1 in 63-100% purities and 36-89% isolated yields. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.05.096

文献信息

• Solid-phase synthesis of quinoxaline derivatives using 6-amino-2,3-dichloroquinoxaline loaded on AMEBA resin
  作者：Moon-Kook Jeon、Dong-Su Kim、Hyun Ju La、Young-Dae Gong

  DOI：10.1016/j.tetlet.2005.05.096

  日期：2005.7

  The solid-phase synthesis of quinoxaline derivatives 1 was accomplished through successive introduction of building blocks such as amines. methoxide, acid chlorides, and isocyanates into 6-amimo-2,3-dichloroquinoxaline 2 loaded on AMEBA resin 3. The method made it possible to obtain the compound 1 in 63-100% purities and 36-89% isolated yields. (c) 2005 Elsevier Ltd. All rights reserved.