1,3-di(thiourea-4-phenoxy)propane | 146885-98-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,3-di(thiourea-4-phenoxy)propane
• 英文别名: [4-[3-[4-(Carbamothioylamino)phenoxy]propoxy]phenyl]thiourea
• CAS: 146885-98-5
• 化学式: C₁₇H₂₀N₄O₂S₂
• 分子量: 376.503
• InChiKey: FOCOIZCRNJUQPY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  159
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,3-di(thiourea-4-phenoxy)propane 在 sodium molybdate 、 双氧水 作用下， 以 乙醇 为溶剂， 以54%的产率得到
  参考文献：
  名称：

  Biological properties of amidinium sulfinic and sulfonic acid derivatives: inhibition of glycolytic enzymes of Trypanosoma brucei and protective effect on cell growth

  摘要：

  The activity of the title compounds has been investigated on two biological targets: cultures of trypanosome and glycolytic enzymes inhibition of the parasite, and on retinal epithelium cells. In both cases, these compounds exhibit a significant activity, in some cases more selective than this for the drug suramin, with a lower toxicity. The effect of these compounds, which exist as neutral and zwitterionic forms in the case of sulfinic, only as zwitterionic in the case of sulfonic derivatives can be understood via their action on clusters of positive charges which are present at the surface of the proteins involved in the processes: glycolytic enzymes of the trypanosome in the first part, basic fibroblast growth factor in the second.

  DOI：

  10.1016/0223-5234(92)90114-g
• 作为产物：
  描述：

  3-硝基苯肼盐酸盐 在 盐酸 作用下， 以 水 为溶剂， 反应 1.0h， 生成 1,3-di(thiourea-4-phenoxy)propane
  参考文献：
  名称：

  Biological properties of amidinium sulfinic and sulfonic acid derivatives: inhibition of glycolytic enzymes of Trypanosoma brucei and protective effect on cell growth

  摘要：

  The activity of the title compounds has been investigated on two biological targets: cultures of trypanosome and glycolytic enzymes inhibition of the parasite, and on retinal epithelium cells. In both cases, these compounds exhibit a significant activity, in some cases more selective than this for the drug suramin, with a lower toxicity. The effect of these compounds, which exist as neutral and zwitterionic forms in the case of sulfinic, only as zwitterionic in the case of sulfonic derivatives can be understood via their action on clusters of positive charges which are present at the surface of the proteins involved in the processes: glycolytic enzymes of the trypanosome in the first part, basic fibroblast growth factor in the second.

  DOI：

  10.1016/0223-5234(92)90114-g

文献信息

• Biological properties of amidinium sulfinic and sulfonic acid derivatives: inhibition of glycolytic enzymes of Trypanosoma brucei and protective effect on cell growth
  作者：M Willson、JJ Périé、F Malecaze、F Opperdoes、M Callens

  DOI：10.1016/0223-5234(92)90114-g

  日期：1992.11

  The activity of the title compounds has been investigated on two biological targets: cultures of trypanosome and glycolytic enzymes inhibition of the parasite, and on retinal epithelium cells. In both cases, these compounds exhibit a significant activity, in some cases more selective than this for the drug suramin, with a lower toxicity. The effect of these compounds, which exist as neutral and zwitterionic forms in the case of sulfinic, only as zwitterionic in the case of sulfonic derivatives can be understood via their action on clusters of positive charges which are present at the surface of the proteins involved in the processes: glycolytic enzymes of the trypanosome in the first part, basic fibroblast growth factor in the second.