科绕魏素 | 484-34-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 中文名称: 科绕魏素
• 英文名称: croweacin
• 英文别名: 5-allyl-4-methoxy-benzo[1,3]dioxole；5-Allyl-4-methoxy-benzo[1,3]dioxol；4-methoxy-5-prop-2-enyl-1,3-benzodioxole
• CAS: 484-34-4
• 化学式: C₁₁H₁₂O₃
• 分子量: 192.214
• InChiKey: VGXJTTXSNPYTSK-UHFFFAOYSA-N

物化性质

• 沸点：
  147-148 °C
• 密度：
  1.1460 g/cm3(Temp: 15 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  科绕魏素 在 potassium permanganate 、 水 、 丙酮 作用下， 生成 2-methoxy-3,4-methylenedioxybenzoic acid
  参考文献：
  名称：

  Penfold et al., Journal of the Chemical Society, 1938, p. 756

  摘要：

  DOI：

文献信息

• Baker et al., Journal of the Chemical Society, 1939, p. 439,441
  作者：Baker et al.

  DOI：——

  日期：——
• METHOD FOR THE EXTRACTION OF SHIKIMIC ACID
  申请人：Bordoloi Manobjyoti

  公开号：US20130137895A1

  公开（公告）日：2013-05-30

  This invention is directed to the production of shikimic acid from Illicium griffithii fruits. The method according to the invention is particularly applicable to the isolation of shikimic acid from Illicium griffithii fruits (seeds and pericarps). Yield is 12-18% w/w. Shikimic acid is useful as raw material for the production of oseltavir (Tamiflu) used against Avian Flu. It is also reported that its triacyl derivatives can inhibit blood platelet assembling and Thrombosis by affecting the metabolism of Arachidonic acid. Hitherto known commercial methods of production of shikimic acid from the fruits of star anise ( Illicium verum ) and sweet gum ( Liquidambar styraciflua ) gives only 3-7% and 1.5% respectively. The price of shikimic acid in the international market varies from US$ 45.00 to 1000.00 per Kg depending on demand. Further as per report published at the website www.livemint.com, China Government has imposed restriction on export of shikimic acid.
• US8912357B2
  申请人：——

  公开号：US8912357B2

  公开（公告）日：2014-12-16
• US9386767B2
  申请人：——

  公开号：US9386767B2

  公开（公告）日：2016-07-12
• [EN] A METHOD FOR THE EXTRACTION OF SHIKIMIC ACID<br/>[FR] PROCÉDÉ POUR L'EXTRACTION D'ACIDE SHIKIMIQUE
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2011110927A1

  公开（公告）日：2011-09-15

  This invention is directed to the production of shikimic acid from Illicium griffithii fruits. The method according to the invention is particularly applicable to the isolation of shikimic acid from Illicium griffithii fruits (seeds and pericarps). Yield is 12-18% w/w. Shikimic acid is useful as raw material for the production of oseltavir (Tamiflu) used against Avian Flu. It is also reported that its triacyl derivatives can inhibit blood platelet assembling and Thrombosis by affecting the metabolism of Arachidonic acid. Hitherto known commercial methods of production of shikimic acid from the fruits of star anise (Illicium verum) and sweet gum (Liquidambar styraciflua) gives only 3-7% and 1.5% respectively. The price of shikimic acid in the international market varies from US$ 45.00 to 1000.00 per Kg depending on demand. Further as per report published at the website www.livemint.com, China Government has imposed restriction on export of shikimic acid.