3-Propyl-hexansaeure-amid | 55327-20-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-Propyl-hexansaeure-amid
• 英文别名: Dipropylpropionamid；3-propyl-hexanoic acid amide；3-n-propylhexanamide；3-Propylhexanamide
• CAS: 55327-20-3
• 化学式: C₉H₁₉NO
• 分子量: 157.256
• InChiKey: KAACLWQGBIEOGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-Hydroxy-3-n-propyl-hexansaeure 生成 3-Propyl-hexansaeure-amid
  参考文献：
  名称：

  Taillandier; Benoit Guyod; Boucherle, European Journal of Medicinal Chemistry, 1975, vol. 10, # 5, p. 453 - 462

  摘要：

  DOI：

文献信息

• .omega.-Dialkylalkanoic acid derivatives used to induce antianoxic
  申请人：Labaz

  公开号：US04246282A1

  公开（公告）日：1981-01-20

  .omega.-Dialkylalkanoic acid derivatives of the formula: ##STR1## in which R.sub.1 and R.sub.2, which can be the same or different, each represent an alkyl radical having from 1 to 4 carbon atoms and n represents 0, 1, 2 or 3. They possess a competitive inhibitory activity with respect to .gamma.-aminobutyric .alpha.-ketoglutaric transaminase as well as antianoxic and anticonvulsant properties and they are useful for treating central neurological disorders, whether resulting or not from cerebral ischemia, and disorders relating to the field of neuropsychiatry.

  该公式的.omega.-二烷基脂肪酸衍生物：##STR1## 其中R.sub.1和R.sub.2可以相同也可以不同，均代表具有1至4个碳原子的烷基基团，n代表0、1、2或3。它们具有相对于.γ.-氨基丁酸.α.-酮戊二酸转氨酶的竞争性抑制活性，以及抗缺氧和抗抽搐性质，适用于治疗中枢神经系统障碍，无论是否由脑缺血引起，以及与神经精神病学领域相关的障碍。
• Thienopyrimidine and Thienopyridine Derivatives Substituted with Cyclic Amino Group
  申请人：Nakazato Atsuro

  公开号：US20070254898A1

  公开（公告）日：2007-11-01

  [Problem to be Solved] An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastral diseases, drug dependence, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alpecia, irritable bowel syndrome, sleep disorders, epilepsy, dermatitides, schizophrenia, etc. [Solution] A thienopyrimidine or thienopyridine derivative substituted with a cyclic amino group represented by the following formula [I]: has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.

  【待解决的问题】本发明的目的是提供一种针对CRF受体的拮抗剂，其作为治疗或预防代理，对CRF参与的疾病具有有效性，例如抑郁症、焦虑症、阿尔茨海默病、帕金森病、亨廷顿舞蹈症、进食障碍、高血压、胃肠疾病、药物依赖、癫痫、脑梗塞、脑缺血、脑水肿、头部外伤、炎症、免疫相关疾病、脱发、肠易激综合症、睡眠障碍、癫痫、皮炎、精神分裂症等。 【解决方案】一种噻唑嘧啶或噻唑吡啶衍生物，其被一个以下式[I]所代表的环状氨基团置换，具有高亲和力的CRF受体，对CRF参与的疾病具有有效性。
• [EN] CRYSTALLINE HIGH DEGREE OF CONDENSATION TITANIUM-BASED INORGANIC-ORGANIC HYBRID SOLID MOF MATERIAL, METHOD FOR PREPARING SAME AND USES THEREOF<br/>[FR] MATÉRIAU MOF SOLIDE HYBRIDÉ INORGANIQUE-ORGANIQUE À BASE DE TITANE, AVEC UN DEGRÉ ÉLEVÉ DE CONDENSATION CRISTALLINE , SON PROCÉDÉ DE PRÉPARATION ET SES UTILISATIONS
  申请人：CENTRE NAT RECH SCIENT

  公开号：WO2017211923A1

  公开（公告）日：2017-12-14

  The present invention relates to a water-stable Titanium-based metal-organic framework (MOF) material having a high degree of condensation, i.e. an oxo to Ti ratio (or oxo to metal ratio, in the case of doped Ti-based MOFs) > 1.0; a process of preparing same and uses thereof, particularly for heterogeneously catalyzed chemical reactions, for gas storage/separation/purification, for information storage, laser printing or as an oxygen indicator, or as proton conductive material (fuel cells), optoelectronic material (photovoltaic cells including Grätzel cells), as a matrix for encapsulating active principles (medicaments, cosmetics), or else as sensing material.

  本发明涉及一种具有高度缩合度的水稳定的基于钛的金属有机框架（MOF）材料，即氧与钛的比例（或掺杂的基于钛的MOF中的氧与金属的比例）> 1.0；其制备方法和用途，特别是用于异相催化化学反应，气体储存/分离/净化，信息存储，激光打印或作为氧指示剂，或作为质子导电材料（燃料电池），光电材料（包括Grätzel电池的光伏电池），作为包埋活性成分（药物，化妆品）的基质，或作为传感材料。
• Crystalline high degree of condensation titanium-based inorganic-organic hybrid solid MOF material, method for preparing same and uses thereof
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

  公开号：US10941166B2

  公开（公告）日：2021-03-09

  The present invention relates to a water-stable Titanium-based metal-organic framework (MOF) material having a high degree of condensation, i.e. an oxo to Ti ratio (or oxo to metal ratio, in the case of doped Ti-based MOFs) >1.0; a process of preparing same and uses thereof, particularly for heterogeneously catalyzed chemical reactions, for gas storage/separation/purification, for information storage, laser printing or as an oxygen indicator, or as proton conductive material (fuel cells), optoelectronic material (photovoltaic cells including Grätzel cells), as a matrix for encapsulating active principles (medicaments, cosmetics), or else as sensing material.

  本发明涉及一种水稳定性钛基金属有机框架（MOF）材料，该材料具有较高的缩合度，即氧化物与钛的比率（或氧化物与金属的比率，在掺杂钛基MOF的情况下）大于1.0；制备方法及其用途，特别是用于异构催化化学反应、气体储存/分离/净化、信息储存、激光打印或作为氧指示剂，或作为质子传导材料（燃料电池）、光电材料（光伏电池，包括格栅电池）、作为封装活性成分的基质（药物、化妆品），或作为传感材料。
• Keil, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1947, vol. 282, p. 139
  作者：Keil

  DOI：——

  日期：——