4-(4-Nitro-furazan-3-yl)-morpholine | 292856-41-8

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 英文名称: 4-(4-Nitro-furazan-3-yl)-morpholine
• 英文别名: 4-(4-Nitro-1,2,5-oxadiazol-3-yl)morpholine
• CAS: 292856-41-8
• 化学式: C₆H₈N₄O₄
• 分子量: 200.154
• InChiKey: GUWBAOUILLXZIV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  97.2
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  4-(4-Nitro-furazan-3-yl)-morpholine 在 sodium hydroxide 作用下， 以 丙酮 为溶剂， 以90%的产率得到4-Morpholin-4-yl-furazan-3-ol
  参考文献：
  名称：

  Sheremetev; Kharitonova; Mantseva, Russian Journal of Organic Chemistry, 1999, vol. 35, # 10, p. 1525 - 1537

  摘要：

  DOI：
• 作为产物：
  描述：

  吗啉 、 3,4-dinitrofurazan 以 二氯甲烷 为溶剂， 以75%的产率得到4-(4-Nitro-furazan-3-yl)-morpholine
  参考文献：
  名称：

  Synthesis of secondary and tertiary aminofurazans

  摘要：

  Reactions of nitrofurazans with primary and secondary amines were studied. Conditions were found which allow the efficient replacement of the nitro group with these nucleophiles. Transformations of the amidoxime fragment, which is bound to the furazan ring and contains an amino substituent, enable one to substantially expand the spectrum of polyfunctional derivatives. The structures of the amines synthesized were studied by X-ray diffraction analysis.

  DOI：

  10.1023/b:rucb.0000035644.16331.f0

文献信息

• Synthesis of secondary and tertiary aminofurazans
  作者：A. B. Sheremetev、V. G. Andrianov、E. V. Mantseva、E. V. Shatunova、N. S. Aleksandrova、I. L. Yudin、D. E. Dmitriev、B. B. Averkiev、M. Yu. Antipin

  DOI：10.1023/b:rucb.0000035644.16331.f0

  日期：2004.3

  Reactions of nitrofurazans with primary and secondary amines were studied. Conditions were found which allow the efficient replacement of the nitro group with these nucleophiles. Transformations of the amidoxime fragment, which is bound to the furazan ring and contains an amino substituent, enable one to substantially expand the spectrum of polyfunctional derivatives. The structures of the amines synthesized were studied by X-ray diffraction analysis.
• Sheremetev; Kharitonova; Mantseva, Russian Journal of Organic Chemistry, 1999, vol. 35, # 10, p. 1525 - 1537
  作者：Sheremetev、Kharitonova、Mantseva、Kulagina、Shatunova、Aleksandrova、Mel'nikova、Ivanova、Dmitriev、Eman、Yudin、Kuz'min、Strelenko、Novikova、Lebedev、Khmel'nitskii

  DOI：——

  日期：——