4-methylstyrenesulfonic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methylstyrenesulfonic acid
• 英文别名: (E)-2-(4-methylphenyl)ethenesulfonic acid
• 化学式: C₉H₁₀O₃S
• 分子量: 198.243
• InChiKey: BBYUVXVYRXMRCG-VOTSOKGWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  62.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-methylstyrenesulfonic acid 在 磺酰氯 、 三苯基膦 作用下， 以 二氯甲烷 为溶剂， 反应 0.25h， 生成 2-(4-甲基苯基)乙烯磺酰氯
  参考文献：
  名称：

  Sulfonylated aminothiazoles as new small molecule inhibitors of protein phosphatases

  摘要：

  Based on a previously identified lead structure, SC-alpha alpha delta9, we have developed a versatile new chemical scaffold that can be readily modified to generate libraries of both Tyr and dual specificity phosphatase inhibitors with reduced molecular weight and lipophilicity. The most potent analogue identified to dare, aminothiazole 8z, inhibits the dual specificity phosphatase Cdc25B with a K-i of 4.6 +/- 0.4 muM and a Hill coefficient of 2. (C) 2001 Elsevier Science Ltd. Ail rights reserved.

  DOI：

  10.1016/s0960-894x(00)00658-2
• 作为产物：
  描述：

  ethyl (E)-2-(4-methylphenyl)ethenesulfonate 在 四丁基碘化铵 作用下， 以 丙酮 为溶剂， 生成 4-methylstyrenesulfonic acid
  参考文献：
  名称：

  Sulfonylated aminothiazoles as new small molecule inhibitors of protein phosphatases

  摘要：

  Based on a previously identified lead structure, SC-alpha alpha delta9, we have developed a versatile new chemical scaffold that can be readily modified to generate libraries of both Tyr and dual specificity phosphatase inhibitors with reduced molecular weight and lipophilicity. The most potent analogue identified to dare, aminothiazole 8z, inhibits the dual specificity phosphatase Cdc25B with a K-i of 4.6 +/- 0.4 muM and a Hill coefficient of 2. (C) 2001 Elsevier Science Ltd. Ail rights reserved.

  DOI：

  10.1016/s0960-894x(00)00658-2

文献信息

• SYNTHETIC RESIN EMULSION POWDER
  申请人：Tanimoto Seiji

  公开号：US20080293884A1

  公开（公告）日：2008-11-27

  Disclosed is a synthetic resin emulsion powder obtained by spray-drying a composition that comprises an emulsion (A) where the dispersoid is a polymer that having one or more unsaturated monomer units selected from ethylenic unsaturated monomers and dienic monomers, and a polyvinyl alcohol (B) having, in the molecule, from 1 to 12 mol % of ethylene units. The emulsion powder has good redispersibility and good water resistance. Its redispersion well form good films and has good storage stability at low temperatures. The emulsion powder is favorable for additives to hydraulic substances, as it well disperses in hydraulic substances such as cement mortar and gives hardened articles of high mechanical strength. The emulsion powder is also favorable for joint materials for hydraulic substances, as its adhesiveness and durability are both good and gives jointed articles of high mechanical strength.

  本发明公开了一种合成树脂乳液粉末，其通过喷雾干燥包含乳液（A）和聚乙烯醇（B）的组合物制得。其中，分散体是具有一种或多种乙烯基不饱和单体和二烯基单体的聚合物，聚乙烯醇（B）的分子中含有1-12摩尔％的乙烯基。该乳液粉末具有良好的再分散性和良好的耐水性。它的再分散性良好，形成的薄膜良好，并且在低温下具有良好的储存稳定性。该乳液粉末适用于水泥砂浆等水泥性物质的添加剂，因为它可以很好地分散在水泥性物质中，并且可以给出高机械强度的硬化制品。该乳液粉末也适用于水泥性物质的接缝材料，因为它的粘附性和耐久性都很好，并且可以给出高机械强度的接缝制品。
• METHODS OF REDUCING VIRULENCE IN BACTERIA
  申请人：Yang Ching-Hong

  公开号：US20120322769A1

  公开（公告）日：2012-12-20

  A method of reducing virulence in a bacterium comprising at least one of a GacS/GacA-type system, a HrpX/HrpY-type system, a T3SS-type system, and a Rsm-type system, the method comprising contacting the bacterium with an effective amount of a compound described herein.

  一种减少细菌毒力的方法，包括至少一种GacS/GacA型系统、HrpX/HrpY型系统、T3SS型系统和Rsm型系统中的一种，该方法包括将细菌与本文所述化合物的有效量接触。
• SERINE RACEMASE INHIBITOR
  申请人：National University Corporation University of Toyama

  公开号：US20140371291A1

  公开（公告）日：2014-12-18

  A novel serine racemase inhibitor exhibits sufficient activity and specificity. The serine racemase inhibitor includes one or more compounds selected from compounds respectively represented by the following general formulas [MM_1], [DR_1], [DR′_1], [LW_1], and [ED_1] as an active ingredient.

  一种新型的丝氨酸外消旋酶抑制剂表现出足够的活性和特异性。该丝氨酸外消旋酶抑制剂包括一种或多种选自以下通用式[MM_1]、[DR_1]、[DR′_1]、[LW_1]和[ED_1]所代表的化合物的化合物作为活性成分。
• A process for preparing poly(P-methylstyrene)
  申请人：MOBIL OIL CORPORATION

  公开号：EP0084715A1

  公开（公告）日：1983-08-03

  Poly(methylstyrene) suitable for injection molding has a molecular weight distribution of at least 4.0, a melt index of at least 5 and comprises the polymerization product of methylstyrene isomers in the following proportions: p-methylstyrene at least 90 weight percent; m-methylstyrene 0 to 10 weight percent; o-methylstyrene less than 0.1 weight percent. The product is prepared by mixing substantially all of the methylstyrene isomer mixture to be polymerized with polymerization initiators including a high temperature initiator and a low temperature initiator and reacting the mixture at a temperature sufficient to effect the required polymerization.

  适用于注塑成型的聚甲基苯乙烯的分子量分布至少为 4.0，熔融指数至少为 5，由甲基苯乙烯异构体按以下比例聚合而成： 对甲基苯乙烯 至少占 90%的重量百分比； 间甲基苯乙烯 0 至 10 重量百分比； 邻甲基苯乙烯小于 0.1%。 该产品的制备方法是将基本上所有待聚合的甲基苯乙烯异构体混合物与聚合引发剂（包括高温引发剂和低温引发剂）混合，并在足以实现所需聚合的温度下对混合物进行反应。
• Synthetic resin powder
  申请人：Kuraray Co., Ltd.

  公开号：EP0765885A1

  公开（公告）日：1997-04-02

  There is disclosed a synthetic resin powder comprising a polymer made from an ethylenically unsaturated monomer or a diolefinic monomer and a polyvinyl alcohol chemically bonded through a sulfide bond at an end thereof to the surface of a particle of the polymer. Although the synthetic resin powder of the present invention can be in the form of powder during transportation, it can easily be dispersed in water by adding water thereto under stirring, because it is excellent in dispersibility in water and blocking resistance. The synthetic resin powder is excellent also in film forming properties, and thus can preferably be used as an admixture for a mortar, etc.

  本发明公开了一种合成树脂粉末，它由乙烯不饱和单体或二烯烃单体制成的聚合物和聚乙烯醇组成，聚乙烯醇的一端通过硫化物键与聚合物颗粒的表面化学键合。虽然本发明的合成树脂粉在运输过程中可能呈粉末状，但由于其在水中的分散性和抗阻塞性极佳，在搅拌下加水即可轻松将其分散在水中。本发明的合成树脂粉末还具有优异的成膜性能，因此最好用作灰浆等的外加剂。