[3-cyano-4-(2-methoxyphenyl)-6-phenylpyridin-2-ylsulfanyl]-N-phenylacetamide | 384858-67-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: [3-cyano-4-(2-methoxyphenyl)-6-phenylpyridin-2-ylsulfanyl]-N-phenylacetamide
• 英文别名: 2-{[3-cyano-4-(2-methoxyphenyl)-6-phenylpyridin-2-yl]sulfanyl}-N-phenylacetamide；2-[3-cyano-4-(2-methoxyphenyl)-6-phenylpyridin-2-yl]sulfanyl-N-phenylacetamide
• CAS: 384858-67-7
• 化学式: C₂₇H₂₁N₃O₂S
• mdl: MFCD03035305
• 分子量: 451.549
• InChiKey: QQUWEVFSZFVXFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  100
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  [3-cyano-4-(2-methoxyphenyl)-6-phenylpyridin-2-ylsulfanyl]-N-phenylacetamide 在 sodium ethanolate 作用下， 以 乙醇 、 水 为溶剂， 反应 2.0h， 以3.7 g的产率得到3-amino-4-(2-methoxyphenyl)-N,6-diphenylthieno[2,3-b]pyridine-2-carboxamide
  参考文献：
  名称：

  A New Version of Multicomponent Synthesis of 4,6-Diaryl-2-sulfanylidene-1,2-dihydropyridine-3-carbonitrile Derivatives

  摘要：

  Multicomponent condensation of aromatic aldehydes with acetophenones, cyanothioacetamide, and alkylating agents has been shown to provide synthetic routes to various pyridine and thienopyridine derivatives. The structure of some of the synthesized heterocycles has been confirmed by X-ray analysis.

  DOI：

  10.1134/s1070428018090014
• 作为产物：
  描述：

  苯甲酰三氟丙酮 在 N-甲基吗啉 、 potassium hydroxide 作用下， 以 乙醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 生成 [3-cyano-4-(2-methoxyphenyl)-6-phenylpyridin-2-ylsulfanyl]-N-phenylacetamide
  参考文献：
  名称：

  Synthesis of 4-aryl-6-phenyl-2-thioxo-1,2-dihydropyridine-3-carbonitriles by three-component condensation of aromatic aldehydes with cyanothioacetamide and 4,4,4-trifluoro-1-phenylbutane-1,3-dione

  摘要：

  4-Aryl-6-phenyl-2-thioxo-1,2-dihydropyridine-3-carbonitriles were synthesized by three-component condensation of aromatic aldehydes with cyanothioacetamide and 4,4,4-trifluoro-1-phenylbutane-1,3-dione. The reaction involved initial formation of Michael adducts which underwent acyl cleavage.

  DOI：

  10.1134/s1070428011100150

文献信息

• DIARYLPYRIDINE ANTI-VIRAL COMPOUNDS
  申请人：Kineta, Inc.

  公开号：EP2977085A1

  公开（公告）日：2016-01-27

  Disclosed herein are compounds and related compositions for the treatment of viral infection, including RNA viral infection, and compounds that can modulate the RIG-I pathway in vertebrate cells, including compounds that can activate the RIG-I pathway.

  本文披露了用于治疗病毒感染的化合物和相关组合物，包括RNA病毒感染，并且可以调节脊椎动物细胞中的RIG-I途径的化合物，包括可以激活RIG-I途径的化合物。
• Anti-Viral Compounds
  申请人：Iadonato Shawn P.

  公开号：US20130039944A1

  公开（公告）日：2013-02-14

  Disclosed herein are compounds and related compositions for the treatment of viral infection, including RNA viral infection, and compounds that can modulate the RIG-I pathway in vertebrate cells, including compounds that can activate the RIG-I pathway.
• US9301952B2
  申请人：——

  公开号：US9301952B2

  公开（公告）日：2016-04-05
• [EN] ANTI-VIRAL COMPOUNDS<br/>[FR] COMPOSÉS ANTIVIRAUX
  申请人：KINETA INC

  公开号：WO2011133727A2

  公开（公告）日：2011-10-27

  Disclosed herein are compounds and related compositions for the treatment of viral infection, including RNA viral infection, and compounds that can modulate the RIG-I pathway in vertebrate cells, including compounds that can activate the RIG-I pathway.
• A New Version of Multicomponent Synthesis of 4,6-Diaryl-2-sulfanylidene-1,2-dihydropyridine-3-carbonitrile Derivatives
  作者：I. V. Dyachenko、V. D. Dyachenko、E. G. Polupanenko、P. V. Dorovatovskii、V. N. Khrustalev、V. G. Nenajdenko

  DOI：10.1134/s1070428018090014

  日期：2018.9

  Multicomponent condensation of aromatic aldehydes with acetophenones, cyanothioacetamide, and alkylating agents has been shown to provide synthetic routes to various pyridine and thienopyridine derivatives. The structure of some of the synthesized heterocycles has been confirmed by X-ray analysis.