2,3-dihydro-2-methyl-1H-pyrrolo[1,2-a]benzimidazole | 134856-49-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2,3-dihydro-2-methyl-1H-pyrrolo[1,2-a]benzimidazole
• 英文别名: 2-Methyl-2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazole
• CAS: 134856-49-8
• 化学式: C₁₁H₁₂N₂
• 分子量: 172.23
• InChiKey: KKJSGIGUGAIDPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-(2-methylprop-2-enyl)-2-nitrobenzenamine 在 dirhodium tetraacetate 、 三苯基膦 盐酸 、 氢气 、 铁粉 作用下， 以 乙醇 、 乙酸乙酯 为溶剂， 70.0 ℃ 、2.76 MPa 条件下， 反应 20.0h， 生成 2,3-dihydro-2-methyl-1H-pyrrolo[1,2-a]benzimidazole
  参考文献：
  名称：

  铑催化的N-烯基-1,2-二氨基苯的羰基化合成含稠环脂环的苯并咪唑

  摘要：

  铑催化的N-烯基-1,2-二氨基苯（3）与氢和一氧化碳的反应以优异的收率得到了含有稠合脂环族环（（8）和（9））的苯并咪唑。在某些情况下，可以分离出中间双环化合物，并且其中一种（3,4,5,6-四氢-4-甲基-3H-1,6-苯并重氮化合物）（1）的1 H和13 C nmr光谱显示不寻常的阻转异构现象的证据。

  DOI：

  10.1016/s0040-4020(01)90361-8

文献信息

• Intermolecular Coupling of Isomerizable Alkenes to Heterocycles via Rhodium-Catalyzed C−H Bond Activation
  作者：Kian L. Tan、Robert G. Bergman、Jonathan A. Ellman

  DOI：10.1021/ja0281129

  日期：2002.11.1

  intermolecular coupling of unactivated alkenes, including isomerizable alkenes, to a range of heterocycles using a Rh(I) catalyst. A variety of functional groups were incorporated, including esters, nitriles, and acetals. The intermolecular coupling became possible after it was discovered that weak acids dramatically increase the rate of both the inter- and intramolecular reactions.

  该报告首次使用 Rh(I) 催化剂将未活化的烯烃（包括可异构化的烯烃）分子间偶联到一系列杂环上。引入了多种官能团，包括酯、腈和缩醛。在发现弱酸显着提高分子间和分子内反应的速率后，分子间偶联成为可能。
• Synthesis of 2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazoles via the cyclopropyliminium rearrangement of substituted 2-cyclopropylbenzimidazoles
  作者：Rinat F. Salikov、Dmitry N. Platonov、Aleksandr E. Frumkin、Dmitry L. Lipilin、Yury V. Tomilov

  DOI：10.1016/j.tet.2013.02.021

  日期：2013.4

  2-Cyclopropylbenzimidazole derivatives with various substituents in the small ring undergo cyclopropyliminium rearrangement into 2,3-dihydropyrrolobenzimidazoles substituted at positions 1, 2 or 3. The substrates containing a functional group in position 1 of the cyclopropane ring form products substituted at position 3. Substituents at position 2 in most cases lead to the formation of a mixture of isomers. The reaction can be directed to yield one of the isomers predominantly by varying the solvent polarity. (C) 2013 Elsevier Ltd. All rights reserved.
• Microwave-Assisted C−H Bond Activation:  A Rapid Entry into Functionalized Heterocycles
  作者：Kian L. Tan、Anil Vasudevan、Robert G. Bergman、Jonathan A. Ellman、Andrew J. Souers

  DOI：10.1021/ol030050j

  日期：2003.6.1

  [GRAPHICS]Microwave irradiation strongly accelerates the rhodium-catalyzed intramolecular coupling of a benzimidazole C-H bond to pendant alkenes. The cyclic products were formed in moderate to excellent yields with reaction times less than 20 min. Additionally, the use of microwave irradiation allowed the reactions to be performed without any solvent purification and with minimal precautions to exclude air.
• Annulation of Alkenyl-Substituted Heterocycles via Rhodium-Catalyzed Intramolecular C−H Activated Coupling Reactions
  作者：K. L. Tan、R. G. Bergman、J. A. Ellman

  DOI：10.1021/ja0058738

  日期：2001.3.1
• A metal catalysed route to benzimidazoles containing a fused alicyclic ring
  作者：Despina Anastasiou、Hassan Chaouk、W. Roy Jackson

  DOI：10.1016/s0040-4039(00)74365-6

  日期：1991.11

  Rhodium catalysed reactions of N-alkenyl-1,2-diaminobenzenes (1) with hydrogen and carbon monoxide give benzimidazoles containing a fused alicyclic ring (6,7) in excellent yields.