5,5-diallyl-3-[2-(3,4-dimethoxyphenyl)-ethyl]thiazolidine-2,4-dione | 1010417-09-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5,5-diallyl-3-[2-(3,4-dimethoxyphenyl)-ethyl]thiazolidine-2,4-dione
• 英文别名: 3-[2-(3,4-Dimethoxyphenyl)ethyl]-5,5-bis(prop-2-enyl)-1,3-thiazolidine-2,4-dione；3-[2-(3,4-dimethoxyphenyl)ethyl]-5,5-bis(prop-2-enyl)-1,3-thiazolidine-2,4-dione
• CAS: 1010417-09-0
• 化学式: C₁₉H₂₃NO₄S
• 分子量: 361.462
• InChiKey: YFFFSOJRFDLJQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  25
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  81.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5,5-diallyl-3-[2-(3,4-dimethoxyphenyl)-ethyl]thiazolidine-2,4-dione 、 氯丙烯镁 以 四氢呋喃 为溶剂， 反应 6.0h， 以88%的产率得到4,5,5-triallyl-3-[2-(3,4-dimethoxyphenyl)ethyl]-4-hydroxythiazolidine-2-one
  参考文献：
  名称：

  Stereoselective synthesis of thiaerythrinanes based on an α-amidoalkylation/RCM approach

  摘要：

  Parham cyclisation-intermolecular alpha-amidoalkylation and nucleophilic addition-intramolecular alpha-amidoalkylation sequences constitute diastereocomplementary routes to 1,10b-cis and trans thiazolo[4,3-a]isoquinolinones. These thiazolidinediones, that incorporate allyl groups at C-1 and C-10b, are efficient precursors of thiacrythrinanes by ring-closing metathesis reactions. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.11.053
• 作为产物：
  描述：

  丙烯酰碘 、 3-<2-(3,4-dimethoxyphenyl)ethyl>thiazolidine-2,4-dione 在 四甲基乙二胺 、 仲丁基锂 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以40%的产率得到5,5-diallyl-3-[2-(3,4-dimethoxyphenyl)-ethyl]thiazolidine-2,4-dione
  参考文献：
  名称：

  Stereoselective synthesis of thiaerythrinanes based on an α-amidoalkylation/RCM approach

  摘要：

  Parham cyclisation-intermolecular alpha-amidoalkylation and nucleophilic addition-intramolecular alpha-amidoalkylation sequences constitute diastereocomplementary routes to 1,10b-cis and trans thiazolo[4,3-a]isoquinolinones. These thiazolidinediones, that incorporate allyl groups at C-1 and C-10b, are efficient precursors of thiacrythrinanes by ring-closing metathesis reactions. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.11.053

文献信息

• Stereoselective synthesis of thiaerythrinanes based on an α-amidoalkylation/RCM approach
  作者：Media Noori Abdullah、Sonia Arrasate、Esther Lete、Nuria Sotomayor

  DOI：10.1016/j.tet.2007.11.053

  日期：2008.2

  Parham cyclisation-intermolecular alpha-amidoalkylation and nucleophilic addition-intramolecular alpha-amidoalkylation sequences constitute diastereocomplementary routes to 1,10b-cis and trans thiazolo[4,3-a]isoquinolinones. These thiazolidinediones, that incorporate allyl groups at C-1 and C-10b, are efficient precursors of thiacrythrinanes by ring-closing metathesis reactions. (c) 2007 Elsevier Ltd. All rights reserved.