4-(3-氟-4-甲氧基苯基)噻唑-2-胺 | 716-75-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 4-(3-氟-4-甲氧基苯基)噻唑-2-胺
• 英文名称: 2-Amino-4-<3-fluor-4-methoxyphenyl>-thiazol
• 英文别名: 4-(3-fluoro-4-methoxy-phenyl)-thiazol-2-ylamine；4-(3-fluoro-4-methoxyphenyl)-1,3-thiazole-2-amine；4-(3-Fluoro-4-methoxyphenyl)-1,3-thiazol-2-amine
• CAS: 716-75-6
• 化学式: C₁₀H₉FN₂OS
• mdl: MFCD02663993
• 分子量: 224.259
• InChiKey: YNGDDNXKDDLUAK-UHFFFAOYSA-N

物化性质

• 溶解度：
  23.8 [ug/mL]

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  76.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-溴-1-(3-氟-4-甲氧基苯基)乙酮 、 硫脲 生成 4-(3-氟-4-甲氧基苯基)噻唑-2-胺
  参考文献：
  名称：

  Maziere,M. et al., Bulletin de la Societe Chimique de France, 1963, p. 1000 - 1003

  摘要：

  DOI：

文献信息

• QUINAZOLINEDIONE DERIVATIVES AS TRPA1 MODULATORS
  申请人：Muthuppalniappan Meyyappan

  公开号：US20090325987A1

  公开（公告）日：2009-12-31

  The present invention provides Quinazolinedione derivatives as TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1.

  本发明提供了喹唑啉二酮衍生物作为TRPA（瞬时受体电位亚家族A）调节剂。具体来说，本文描述的化合物可用于治疗或预防由TRPA1（瞬时受体电位亚家族A，成员1）调节的疾病、病况和/或疾病。本文还提供了制备本文描述的化合物的方法、用于合成的中间体、药物组合物以及治疗或预防由TRPA1调节的疾病、病况和/或疾病的方法。
• [EN] PYRIMIDINEDIONE-FUSED HETEROCYCLIC COMPOUNDS AS TRPA1 MODULATORS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES FUSIONNÉS À UNE PYRIMIDINE DIONE EN TANT QUE MODULATEURS DE TRPA1
  申请人：GLENMARK PHARMACEUTICALS SA

  公开号：WO2010125469A1

  公开（公告）日：2010-11-04

  The present invention is related to novel pyrimidinedione-fused heterocyclic compounds as TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1.

  本发明涉及作为TRPA（瞬时受体电位亚家族A）调节剂的新型嘧啶二酮并环杂环化合物。具体地，本文描述的化合物可用于治疗或预防由TRPA1（瞬时受体电位亚家族A，成员1）调节的疾病、症状和/或疾病。本文还提供了用于制备本文描述的化合物的方法、用于合成的中间体、其药物组成物以及治疗或预防由TRPA1调节的疾病、症状和/或疾病的方法。
• 2-ACYLAMINOTHIAZOLE DERIVATIVE OR SALT THEREOF
  申请人：ASTELLAS PHARMA INC.

  公开号：US20160002218A1

  公开（公告）日：2016-01-07

  [Problem] A compound which is useful as an active ingredient of a pharmaceutical composition for treating storage dysfunctions, voiding dysfunctions, and lower urinary tract diseases is provided. [Means for Solution] The present inventors have found that a thiazole derivative having pyrazine-2-carbonylamino substituted at the 2-position is an excellent muscarinic M 3 receptor positive allosteric modulator, and is useful as an agent for preventing and/or treating bladder or urinary tract diseases, related to bladder contraction by a muscarinic M 3 receptor, thereby completing the present invention. The 2-acylaminothiazole derivative or a salt thereof of the present invention can be used as an agent for preventing and/or treating bladder or urinary tract diseases, related to bladder contraction by a muscarinic M 3 receptor, for example, voiding dysfunctions such as underactive bladder.

  [问题]提供一种化合物，该化合物可用作治疗储存功能障碍、排尿功能障碍和下尿路疾病的药物组合物的活性成分。[解决方案]本发明人发现，在2位取代吡嗪-2-羧酰胺的噻唑衍生物是一种优秀的肌动蛋白M3受体正向变构调节剂，并且可用作预防和/或治疗与肌动蛋白M3受体引起的膀胱收缩有关的膀胱或尿路疾病的药物，从而完成了本发明。本发明的2-酰胺基噻唑衍生物或其盐可用作预防和/或治疗与肌动蛋白M3受体引起的膀胱收缩有关的膀胱或尿路疾病的药物，例如，排尿功能障碍，如无力膀胱。
• 2-ACYLAMINOTHIAZOLE DERIVATIVE AND SALT THEREOF
  申请人：Astellas Pharma Inc.

  公开号：EP2963036B1

  公开（公告）日：2019-08-28
• US7951814B2
  申请人：——

  公开号：US7951814B2

  公开（公告）日：2011-05-31