3-Amino-5-chloro-2-phenylindolizine-1-carbonitrile | 905975-90-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 3-Amino-5-chloro-2-phenylindolizine-1-carbonitrile
• CAS: 905975-90-8
• 化学式: C₁₅H₁₀ClN₃
• 分子量: 267.717
• InChiKey: ODLWJDMOWAOUTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-Amino-5-chloro-2-phenylindolizine-1-carbonitrile 、 乙酰氯 在 TEA 作用下， 以 二氯甲烷 为溶剂， 反应 16.0h， 以32%的产率得到N-(5-chloro-1-cyano-2-phenylindolizin-3-yl)acetamide
  参考文献：
  名称：

  Discovery of protein–protein binding disruptors using multi-component condensations small molecules

  摘要：

  A series of small molecule compounds interfering with the binding process of VEGF and NRP1 has been identified and further optimized. Full synthetic details as well as SAR are reported which demonstrate that expeditious MCC-based syntheses may lead to valuable molecules addressing challenging targets such as protein-protein interactions. Preliminary functional assay data confirm that these compounds may be further developed toward drug candidates. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.05.014
• 作为产物：
  描述：

  5-Chloro-3-[(2,4-dimethoxyphenyl)methylamino]-2-phenylindolizine-1-carbonitrile 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 3-Amino-5-chloro-2-phenylindolizine-1-carbonitrile
  参考文献：
  名称：

  Discovery of protein–protein binding disruptors using multi-component condensations small molecules

  摘要：

  A series of small molecule compounds interfering with the binding process of VEGF and NRP1 has been identified and further optimized. Full synthetic details as well as SAR are reported which demonstrate that expeditious MCC-based syntheses may lead to valuable molecules addressing challenging targets such as protein-protein interactions. Preliminary functional assay data confirm that these compounds may be further developed toward drug candidates. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.05.014

文献信息

• OXIDATION DYEING PROCESS USING A COMPOSITION COMPRISING AN AMINOBENZIMIDAZOLONE OXIDATION BASE AND A METAL CATALYST
  申请人：L'OREAL

  公开号：US20160136077A1

  公开（公告）日：2016-05-19

  The invention relates to a process for dyeing keratin fibres, comprising the use of one or more metal catalysts and of a composition (A) comprising: —one or more oxidizing agents, and —at least one aminobenzimidazole oxidation base of formula (I) in which the radicals R1 to R5 represent, independently of each other, a hydrogen atom; a halogen atom; a C1-C6 alkyl radical; a C1-C6 alkoxy radical; a C1-C6 dialkylamino radical; a carboxylic radical (—COOH); a sulfonic radical (—S03H); a phenyl radical; a sat orated or unsaturated 5- to 7-membered heterocyclic radical, comprising one or more heteroatoms chosen from N, O and S.
• [EN] OXIDATION DYEING PROCESS USING A COMPOSITION COMPRISING AN AMINOBENZIMIDAZOLONE OXIDATION BASE AND A METAL CATALYST<br/>[FR] PROCÉDÉ DE COLORATION PAR OXYDATION À L'AIDE D'UNE COMPOSITION COMPRENANT UNE BASE D'OXYDATION AMINOBENZIMIDAZOLONE ET UN CATALYSEUR MÉTALLIQUE
  申请人：OREAL

  公开号：WO2014202792A2

  公开（公告）日：2014-12-24

  The invention relates to a process for dyeing keratin fibres, comprising the use of one or more metal catalysts and of a composition (A) comprising : - one or more oxidizing agents, and - at least one aminobenzimidazole oxidation base of formula (I) in which the radicals R1 to R5 represent, independently of each other, a hydrogen atom; a halogen atom; a C1-C6 alkyl radical; a C1-C6 alkoxy radical; a C1-C6 dialkylamino radical; a carboxylic radical (- COOH); a sulfonic radical (-S03H); a phenyl radical; a saturated or unsaturated 5- to 7-membered heterocyclic radical, comprising one or more heteroatoms chosen from N, O and S.
• Discovery of protein–protein binding disruptors using multi-component condensations small molecules
  作者：Karim Bedjeguelal、Hugues Bienaymé、Antoine Dumoulin、Stéphane Poigny、Philippe Schmitt、Eric Tam

  DOI：10.1016/j.bmcl.2006.05.014

  日期：2006.8

  A series of small molecule compounds interfering with the binding process of VEGF and NRP1 has been identified and further optimized. Full synthetic details as well as SAR are reported which demonstrate that expeditious MCC-based syntheses may lead to valuable molecules addressing challenging targets such as protein-protein interactions. Preliminary functional assay data confirm that these compounds may be further developed toward drug candidates. (c) 2006 Elsevier Ltd. All rights reserved.