1,12-diacetamidododecane | 31991-77-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,12-diacetamidododecane
• 英文别名: N,N'-Diacetyl-1,12-dodecandiamin；N,N'-Diacetyl-1.12-diamino-dodecan；N-(12-acetamidododecyl)acetamide
• CAS: 31991-77-2
• 化学式: C₁₆H₃₂N₂O₂
• 分子量: 284.442
• InChiKey: FDLURLCYBKOPIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  20
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,12-diacetamidododecane 在 二异丁基氢化铝 作用下， 以 甲苯 为溶剂， 以90%的产率得到1,12-bis(N-ethylamino)dodecane
  参考文献：
  名称：

  N,N'-二取代的α,ω-烷二胺、线性双二硫代氨基甲酸酯的前体的合成

  摘要：

  摘要 线性双二硫代氨基甲酸酯可方便地从对称双取代的 α,ω-链烷二胺获得，其制备方法已有报道。

  DOI：

  10.1080/00397919608003643
• 作为产物：
  描述：

  1,12-二氨基十二烷 、 乙酸酐 在 吡啶 作用下， 以97%的产率得到1,12-diacetamidododecane
  参考文献：
  名称：

  Der [M + 11] + -Pick in Mass Masspeperen von Diaminen 38. Mitteilungübermassenspektrometrische Untersuchungen †

  摘要：

  二胺类质谱中的[M + U] + -峰

  DOI：

  10.1002/hlca.19820650521

文献信息

• USE OF COMPOUNDS WITH NITROGEN-CONTAINING FUNCTIONAL GROUPS FOR THERMAL ENERGY STORAGE
  申请人：Hidalgo Manuel

  公开号：US20130056175A1

  公开（公告）日：2013-03-07

  The present invention relates to the use of a compound consisting of a linear saturated C 8 -C 24 hydrocarbon-based chain bearing at each end a nitrogen-containing functional group, other than —NH 2 , for the storage of thermal energy. It also relates to a process for the storage and optionally for the release of thermal energy, comprising the contacting of a wall to be cooled with a first heat transfer fluid then of said first heat transfer fluid with a material comprising said compound and optionally the contacting of said material with a second heat transfer fluid then of said second heat transfer fluid with a wall to be heated.

  本发明涉及使用一种化合物，该化合物由一个线性饱和的C8-C24碳氢基链组成，每端带有一个含氮的功能基团（不包括—NH2），用于储存热能。它还涉及一种用于储存和可选释放热能的过程，包括将待冷却的壁与第一热传递流体接触，然后将该第一热传递流体与包含该化合物的材料接触，以及可选地将该材料与第二热传递流体接触，然后将该第二热传递流体与待加热的壁接触。
• METHOD FOR PRODUCING CARBAMATE COMPOUND
  申请人：Ube Industries, Ltd.

  公开号：EP2325167A1

  公开（公告）日：2011-05-25

  A task of the present invention is to provide a process for preparation a carbamate compound using a carbonic acid ester and an amide compound in the presence of a basic compound(s), wherein the process is a novel industrial method which is advantageous in that the reaction rate is faster than conventional and the by-produced ester compound can be recovered, and the present invention is directed to a method comprising reacting an amide compound represented by the formula (1) with a carbonic acid ester represented by the formula (2) in the presence of a basic compound(s) to obtain a carbamate compound represented by the formula (3).

  本发明的任务是提供一种在碱性化合物存在下使用碳酸酯和酰胺化合物制备氨基甲酸 酯化合物的工艺，其中该工艺是一种新颖的工业方法，其优点是反应速率比传统方法快， 且副生成的酯化合物可以回收、本发明涉及一种方法，包括在碱性化合物存在下，使式（1）代表的酰胺化合物与式（2）代表的碳酸酯反应，得到式（3）代表的氨基甲酸酯化合物。
• Synthetic polyamine analogs as antineoplastics
  作者：Raymond J. Bergeron、Allen H. Neims、James S. McManis、Thomas R. Hawthorne、John R. T. Vinson、Rita Bortell、Michael J. Ingeno

  DOI：10.1021/jm00401a019

  日期：1988.6

  In this paper, we report on the synthesis and biological activity of a number of N-alkylated spermine compounds. The dialkylspermines N1,N12-dimethylspermine (DMSPM-2), N1,N12-diethylspermine (DESPM-3), and N1,N12-dipropylspermine (DPSPM-4) are all shown to inhibit the growth of L1210 cells in culture with IC50 values of less than 1 microM at 96 h. Furthermore, DESPM-3 is shown to be similarly active against Daudi and HL-60 cells in culture. A structure-activity relationship is shown to exist between the position at which spermine is alkylated and its antiproliferative properties. The activity of 10 microM DESPM-3 against L1210 cells was shown to be cytostatic, with greater than 90% cell viability by trypan blue exclusion, even after a 144-h exposure. When L1210 cells were treated with 10 microM DESPM-3 over a 144-h period, their size and mitochondrial DNA content were gradually but substantially diminished. However, flow cytometric measurements of the nuclear DNA content of these treated cells at 96 h indicated only slightly reduced S and G2 populations and significant changes only after 144 h. A cloning assay performed on the cells after 96 h of exposure to this drug (10 microM) indicated that the cells were not growing. Finally, when male DBA/2 mice, inoculated with L1210 leukemia cells, were treated with DESPM-3, their life span was increased in excess of 200% relative to untreated controls. Moreover, many long-term survivors were apparently tumor free at the end of the experiment (60 days).
• BERGERON, RAYMOND J.;NEIMS, ALLEN H.;MCMANIS, JAMES S.;HAWTHORNE, THOMAS +, J. MED. CHEM., 31,(1988) N 6, 1183-1190
  作者：BERGERON, RAYMOND J.、NEIMS, ALLEN H.、MCMANIS, JAMES S.、HAWTHORNE, THOMAS +

  DOI：——

  日期：——
• INJECTION MOLDABLE AMIDE-IMIDE POLYMERS CONTAINING DIVALENT ALIPHATIC RADICALS DERIVED FROM ALIPHATIC DIAMINES
  申请人：AMOCO CORPORATION

  公开号：EP0043853B1

  公开（公告）日：1985-11-13