(2S,4'S,5'S)-2-(4-methoxymethyl-5-phenyl-2-oxazolin-2-yl)-1-oxaspiro[2,5]octane | 355410-80-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2S,4'S,5'S)-2-(4-methoxymethyl-5-phenyl-2-oxazolin-2-yl)-1-oxaspiro[2,5]octane
• 英文别名: (4S,5S)-4-(methoxymethyl)-2-[(2S)-1-oxaspiro[2.5]octan-2-yl]-5-phenyl-4,5-dihydro-1,3-oxazole
• CAS: 355410-80-9
• 化学式: C₁₈H₂₃NO₃
• 分子量: 301.386
• InChiKey: AOECYRWOWAYWBJ-HRCADAONSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2S,4'S,5'S)-2-(4-methoxymethyl-5-phenyl-2-oxazolin-2-yl)-1-oxaspiro[2,5]octane 在 盐酸 作用下， 以 甲醇 为溶剂， 反应 1.5h， 以85%的产率得到(2S,1'S,2'S)-(+)-2-(cyclohexen-1-yl)-2-hydroxy-N-(2-hydroxy-1-methoxymethyl-2-phenylethyl)acetamide
  参考文献：
  名称：

  Azaenolates of 2-Chloromethyl-4-methoxymethyl-5-phenyl-2-oxazoline − A Highly Diastereo- and Enantioselective Synthesis of Oxazolinyloxiranes

  摘要：

  The oxazoline-derived titanium azaenolate 6 couples highly stereoselectively with aldehydes affording highly optically pure oxazolinyloxiranes 7. The epoxide 7a has been deblocked to form the optically pure formyl oxirane 9. In contrast, the corresponding boron azaenolates 2 and 3 couple with very poor or no stereoselectivity. Lithium, aluminum and tin azaenolates have also been shortly studied.

  DOI：

  10.1002/1099-0690(200106)2001:11<2035::aid-ejoc2035>3.0.co;2-r
• 作为产物：
  描述：

  (4S,5S)-(-)-4-甲氧甲基-2-甲基-5-苯基-2-恶唑啉 在 sodium hydroxide 、 次氯酸叔丁酯 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 四氯化碳 、 异丙醇 为溶剂， 反应 4.0h， 生成 (2S,4'S,5'S)-2-(4-methoxymethyl-5-phenyl-2-oxazolin-2-yl)-1-oxaspiro[2,5]octane
  参考文献：
  名称：

  On the coupling reaction of lithium azaenolates of chiral oxazolines with carbonyl compounds

  摘要：

  Optically pure chloromethyloxazolines have been prepared, lithiated and then reacted with benzophenone to famish stereoselectively oxazolinyl oxiranes and formyl oxiranes. The stereoselection observed has been related to the geometry of the intermediate lithium azaenolates. Calculations have been carried out in order to evaluate the relative stability of the E and Z forms of the lithium azaenolates. The reaction of a lithium azaenolate with other ketones leading to oxazolinyl epoxides is also reported. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00611-1