1-(2-O-methyl-β-D-ribo-furanosyl)-6-(1,2-diacetoxyethyl)-4-ethoxy-2-pyrimidinone | 259823-19-3

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 1-(2-O-methyl-β-D-ribo-furanosyl)-6-(1,2-diacetoxyethyl)-4-ethoxy-2-pyrimidinone
• CAS: 259823-19-3
• 化学式: C₁₈H₂₆N₂O₁₀
• 分子量: 430.412
• InChiKey: HHXBWLOOZXQGPJ-KIPILBKWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.93
• 重原子数：
  30.0
• 可旋转键数：
  9.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  155.64
• 氢给体数：
  2.0
• 氢受体数：
  12.0

反应信息

• 作为反应物：
  描述：

  1-(2-O-methyl-β-D-ribo-furanosyl)-6-(1,2-diacetoxyethyl)-4-ethoxy-2-pyrimidinone 在 吡啶 、 4,5-二氰基咪唑 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 3.5h， 生成 6-(1,2-diacetoxyethyl)-1-[5-O-(4,4'-dimethoxytrityl)-2-O-methyl-β-D-ribo-furanosyl]-4-ethoxy-2-pyrimidinone-3'-O-(2-cyanosthyl-N,N-diisopropyl)-phosphoramidite
  参考文献：
  名称：

  Introduction of 6-Formylcytidine into a Myb Binding Sequence

  摘要：

  Single 6-formylcytidine was introduced into a oligonucleotide duplex (23 mers) as a substitute for thymidine in the Myb binding sequence of 3'-TTGAC-5'. The modified duplex showed Tm of 67 degrees C, which was six degrees lower than the Tm of the native duplex. Binding affinity of the 23-mers to the Myb protein was estimated by electrophoretic mobility shift assays, and the binding was almost completely abolished.

  DOI：

  10.1080/07328319908044640
• 作为产物：
  描述：

  1-[3,5-bis-O-(tert-butyldimethylsilyl)-2-O-methyl-β-D-ribo-furanosyl]-6-(1,2-dihydroxyethyl)-4-ethoxy-2-pyrimidinone 在 4-二甲氨基吡啶 、 四丁基氟化铵 、 溶剂黄146 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 4.0h， 生成 1-(2-O-methyl-β-D-ribo-furanosyl)-6-(1,2-diacetoxyethyl)-4-ethoxy-2-pyrimidinone
  参考文献：
  名称：

  Introduction of 6-Formylcytidine into a Myb Binding Sequence

  摘要：

  Single 6-formylcytidine was introduced into a oligonucleotide duplex (23 mers) as a substitute for thymidine in the Myb binding sequence of 3'-TTGAC-5'. The modified duplex showed Tm of 67 degrees C, which was six degrees lower than the Tm of the native duplex. Binding affinity of the 23-mers to the Myb protein was estimated by electrophoretic mobility shift assays, and the binding was almost completely abolished.

  DOI：

  10.1080/07328319908044640