(R)-ethyl-5-amino-3-hydroxy-5-oxopentanoate | 717127-73-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: (R)-ethyl-5-amino-3-hydroxy-5-oxopentanoate
• 英文别名: Ethyl (r)-4-carbamoyl-3-hydroxybutanoate；ethyl (3R)-5-amino-3-hydroxy-5-oxopentanoate
• CAS: 717127-73-6
• 化学式: C₇H₁₃NO₄
• 分子量: 175.185
• InChiKey: JDKCSANQGPFQGM-RXMQYKEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  89.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (R)-ethyl-5-amino-3-hydroxy-5-oxopentanoate 、 (2R)-3,3,3-trifluoro-2-hydroxy-2-phenylpropanoyl chloride 在 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Anhydrous Hydration of Nitriles to Amides using Aldoximes as the Water Source

  摘要：

  Anhydrous hydrolysis of nitriles to amides was developed using acetaldoxime as the water source in the presence of Rh catalyst. Conversion of various nitriles to amides was performed under neutral and anhydrous conditions, and the reaction displays excellent compatibility with acid or base labile and hydrolytically labile functional groups.

  DOI：

  10.1021/ol902309z
• 作为产物：
  描述：

  R(-)-4-氰基-3-羟基丁酸乙酯 在 Wilkinson's catalyst 、 2,2-dimethylpropionaldehyde oxime 作用下， 以 甲苯 为溶剂， 反应 4.0h， 以99%的产率得到(R)-ethyl-5-amino-3-hydroxy-5-oxopentanoate
  参考文献：
  名称：

  Anhydrous Hydration of Nitriles to Amides using Aldoximes as the Water Source

  摘要：

  Anhydrous hydrolysis of nitriles to amides was developed using acetaldoxime as the water source in the presence of Rh catalyst. Conversion of various nitriles to amides was performed under neutral and anhydrous conditions, and the reaction displays excellent compatibility with acid or base labile and hydrolytically labile functional groups.

  DOI：

  10.1021/ol902309z

文献信息

• Anhydrous Hydration of Nitriles to Amides using Aldoximes as the Water Source
  作者：Jinwoo Lee、Min Kim、Sukbok Chang、Hee-Yoon Lee

  DOI：10.1021/ol902309z

  日期：2009.12.17

  Anhydrous hydrolysis of nitriles to amides was developed using acetaldoxime as the water source in the presence of Rh catalyst. Conversion of various nitriles to amides was performed under neutral and anhydrous conditions, and the reaction displays excellent compatibility with acid or base labile and hydrolytically labile functional groups.