N,N'-1,3-bisbenzyl-dibutyramide | 205689-18-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N,N'-1,3-bisbenzyl-dibutyramide
• 英文别名: N-[3-(Butyrylamino-methyl)-benzyl]-butyramide；N-[[3-[(butanoylamino)methyl]phenyl]methyl]butanamide
• CAS: 205689-18-5
• 化学式: C₁₆H₂₄N₂O₂
• 分子量: 276.379
• InChiKey: INYQHTSZXMWVKU-UHFFFAOYSA-N

物化性质

• 沸点：
  548.6±43.0 °C(Predicted)
• 密度：
  1.039±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N'-1,3-bisbenzyl-dibutyramide 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 48.0h， 以50%的产率得到N,N'-Dibutyl-m-phenylen-dimethanamin
  参考文献：
  名称：

  Synthesis of Water-soluble Diaza-1,2,5-thiadiazolocyclophanes

  摘要：

  DOI：

  10.3987/com-97-s71
• 作为产物：
  描述：

  间苯二甲胺 、 丁酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.08h， 以95%的产率得到N,N'-1,3-bisbenzyl-dibutyramide
  参考文献：
  名称：

  双苄酰胺类CXCR4拮抗剂及其制备和应用

  摘要：

  本发明公开了双苄酰胺类CXCR4拮抗剂及其制备方法和在制备抗炎、抗肿瘤、通过拮抗CXCR4靶点来防治相关疾病的药物中的应用。双苄酰胺类CXCR4拮抗剂为具有如下通式(I)或(II)的化合物和/或及其可药用盐：本发明采用简便高效的一步法合成了一系列新型的双苄酰胺类CXCR4拮抗剂，具有抗肿瘤、抗炎、抗感染、抗自身免疫等多种药理活性，在众多疾病中具有广泛的应用优势。

  公开号：

  CN113845439A

文献信息

• 双苄酰胺类CXCR4拮抗剂及其制备和应用
  申请人：杭州师范大学

  公开号：CN113845439A

  公开（公告）日：2021-12-28

  本发明公开了双苄酰胺类CXCR4拮抗剂及其制备方法和在制备抗炎、抗肿瘤、通过拮抗CXCR4靶点来防治相关疾病的药物中的应用。双苄酰胺类CXCR4拮抗剂为具有如下通式(I)或(II)的化合物和/或及其可药用盐：本发明采用简便高效的一步法合成了一系列新型的双苄酰胺类CXCR4拮抗剂，具有抗肿瘤、抗炎、抗感染、抗自身免疫等多种药理活性，在众多疾病中具有广泛的应用优势。
• POLYMER FILM, POLARIZING PLATE AND LIQUID CRYSTAL DISPLAY DEVICE
  申请人：FUJIFILM Corporation

  公开号：US20160060405A1

  公开（公告）日：2016-03-03

  The polymer film comprises a carbonyl bond-containing polymer and a compound having δh of equal to or higher than 11.0 and δχ of equal to or lower than 1.50, wherein the δh is a value of hydrogen-bonding capacity calculated by Hoy method and the δχ is a value calculated by equation 1: δχ=| x −13.3|  Equation 1 wherein, in equation 1, χ represents an interatomic distance in the polymer film between atoms most distant from each other among molecules in the compound, excluding a hydrogen atom, calculated by molecular dynamics calculation.
• CELLULOSE ACYLATE FILM, NOVEL COMPOUND, POLARIZING PLATE, AND LIQUID-CRYSTAL DISPLAY DEVICE
  申请人：FUJIFILM Corporation

  公开号：US20160139303A1

  公开（公告）日：2016-05-19

  Disclosed is a cellulose acylate film containing a compound having at least one connecting group selected from a group consisting of a bivalent connecting group denoted by —NH—(C═O)—O— and a bivalent connecting group denoted by —NH—(C═O)—NR— in which R represents a hydrogen atom or a substituent group, and at least one polar group which is a residue of a compound having a C log P value of less than or equal to 0.85 (however, an aromatic hetero ring-containing group which is a residue of a compound having a C log P value of less than or equal to 0.85 is excluded from the polar group), in which an equivalent weight U obtained as a value which is obtained by dividing a molecular weight by the number of connecting groups included in one molecule is less than or equal to 515.
• CELLULOSE ESTER FILM, POLARIZING PLATE, AND LIQUID CRYSTAL DISPLAY DEVICE
  申请人：FUJIFILM Corporation

  公开号：US20160370522A1

  公开（公告）日：2016-12-22

  A cellulose ester film contains a compound having a structural unit denoted by —NR—(C═O)— in which R represents a hydrogen atom or a substituent, a surface having knoop hardness of greater than or equal to 210 N/mm 2 is provided, and loss tangent tan δ at 25° C. is greater than or equal to 0.03.
• Synthesis of Water-soluble Diaza-1,2,5-thiadiazolocyclophanes
  作者：Otohiko Tsuge、Taizo Hatta、Muneo Kawano、Yuji Imaizumi、Akihiko Tsuge、Tetsuji Moriguchi、Hironori Maeda

  DOI：10.3987/com-97-s71

  日期：——