(4S,5S)-4-isopropyl-5-methyl oxazolidinone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: (4S,5S)-4-isopropyl-5-methyl oxazolidinone
• 英文别名: (4S,5S)-5-methyl-4-propan-2-yl-1,3-oxazolidin-2-one
• 化学式: C₇H₁₃NO₂
• 分子量: 143.186
• InChiKey: DXKWZMBVJVXZPZ-WDSKDSINSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (4S)-4-异丙基-5,5-二甲基-1,3-恶唑烷-2-硫酮 在 四氧化锇 sodium tetrahydroborate 、 sodium periodate 、 sodium hydride 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 为溶剂， 生成 (4S,5S)-4-isopropyl-5-methyl oxazolidinone
  参考文献：
  名称：

  Synthesis of N-substituted 2,4-thiazolidinediones from oxazolidinethiones

  摘要：

  A novel reaction has been found between oxazolidinethione and bromoacetyl bromide to afford N-substituted 2,4-thiazolidinediones through an intramolecular nucleophilic substitution reaction. Interestingly a step of elimination was carried out in trisubstituted oxazolidinethiones forming a double bond. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.09.116

文献信息

• Versatile Cp*Co(III)(LX) Catalyst System for Selective Intramolecular C–H Amidation Reactions
  作者：Jia Lee、Jeonghyo Lee、Hoimin Jung、Dongwook Kim、Juhyeon Park、Sukbok Chang

  DOI：10.1021/jacs.0c04448

  日期：2020.7.15

  Herein, we report the development of a tailored cobalt catalyst system of Cp*Co(III)(LX) toward intramolecular C-H nitrene insertion of azidoformates to afford cyclic carbamates. The cobalt complexes were easy to prepare and bench-stable, thus offering a convenient reaction protocol. The catalytic reactivity was significantly improved by the electronic tuning of the bidentate LX ligands, and the observed

  在此，我们报告了针对叠氮甲酸酯的分子内 CH 氮烯插入以提供环状氨基甲酸酯的 Cp*Co(III)(LX) 定制钴催化剂系统的开发。钴配合物易于制备且在实验室中稳定，因此提供了方便的反应方案。双齿LX配体的电子调谐显着提高了催化反应性，并且通过构象分析和过渡态的DFT计算使观察到的区域选择性合理化。新开发的钴催化剂体系的优异性能可广泛应用于温和条件下的 C(sp2)-H 和 C(sp3)-H 氨基甲酸化反应。
• Novel rearrangement of N-enoyl oxazolidinethiones to N-substituted 1,3-thiazine-2,4-diones promoted by NbCl5
  作者：Hector Hernández、Sylvain Bernès、Leticia Quintero、Estibaliz Sansinenea、Aurelio Ortiz

  DOI：10.1016/j.tetlet.2005.12.019

  日期：2006.2

  NbCl5 has been employed as promoter of a novel rearrangement to afford chiral N-substituted 1,3-thiazine-2,4-diones with one or two new stereogenic centers from di- and trisubstituted N-enoyl oxazolidinethiones. The trisubstituted E-isomers provide the anti-diastereomers mainly.

  NbCl 5已被用作新型重排的促进剂，以提供具有一个或两个来自二和三取代的N-烯酰基恶唑烷硫酮的新的立体异构中心的手性N-取代的1,3-噻嗪-2,4-二酮。三取代的E-异构体主要提供抗-非对映异构体。
• Synthesis of N-substituted 2,4-thiazolidinediones from oxazolidinethiones
  作者：Guadalupe Mendoza、Hector Hernández、Leticia Quintero、Martha Sosa-Rivadeneyra、Sylvain Bernès、Estibaliz Sansinenea、Aurelio Ortiz

  DOI：10.1016/j.tetlet.2005.09.116

  日期：2005.11

  A novel reaction has been found between oxazolidinethione and bromoacetyl bromide to afford N-substituted 2,4-thiazolidinediones through an intramolecular nucleophilic substitution reaction. Interestingly a step of elimination was carried out in trisubstituted oxazolidinethiones forming a double bond. (c) 2005 Elsevier Ltd. All rights reserved.