5-{2-[4-(5-mercapto-1,3,4-oxadiazol-2-yl)phenylamino]phenyl}-1,3,4-oxadiazole-2-thiol | 1245567-49-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-{2-[4-(5-mercapto-1,3,4-oxadiazol-2-yl)phenylamino]phenyl}-1,3,4-oxadiazole-2-thiol
• 英文别名: 5-[4-[2-(2-sulfanylidene-3H-1,3,4-oxadiazol-5-yl)anilino]phenyl]-3H-1,3,4-oxadiazole-2-thione
• CAS: 1245567-49-0
• 化学式: C₁₆H₁₁N₅O₂S₂
• 分子量: 369.428
• InChiKey: ZLOOVLLHZRGDQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  143
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  5-{2-[4-(5-mercapto-1,3,4-oxadiazol-2-yl)phenylamino]phenyl}-1,3,4-oxadiazole-2-thiol 、 alkaline earth salt of/the/ methylsulfuric acid 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 24.0h， 以85%的产率得到2-[5-(benzylthio)-1,3,4-oxadiazol-2-yl]-N-{4-[5-(benzylthio)-1,3,4-oxadiazol-2-yl]phenyl}aniline
  参考文献：
  名称：

  Synthesis and biological evaluation of novel 2,4′-bis substituted diphenylamines as anticancer agents and potential epidermal growth factor receptor tyrosine kinase inhibitors

  摘要：

  Four new series of 2,4'-bis diphenylamine hydrazones 14, 2,4'-bis aminothiadiazole 16, 2,4'-bis mercaptotriazole 17-18 and 2,4'-bis mercapto-oxadiazole diphenylamine derivatives 19-20 were synthesized and evaluated for their ability to inhibit EGFR tyrosine kinase. Compound N-ethyl-5-{2-[4(5-(ethylamino)-1,3,4-thiadiazol-2-yl)- phenylaminolphenyl}-1,3,4-thiadiazol-2-amine 16a was the most active enzyme inhibitor (98% inhibition at 10 mu M). Moreover, all compounds that showed enzyme inhibition activity were tested in vitro on human breast carcinoma cell line (MCF-7) in which EGFR is highly expressed. The tested compounds exploited potent antitumor activity with IC50 values ranging 0.73-2.38 mu M. Molecular modeling and docking of the synthesized compounds into the active site of EGFR kinase domain showed good agreement with the obtained biological results. The present work represents a novel class of diphenylamine based derivatives with potent cytotoxicity and promising EGFR PTK inhibition activity. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.05.072
• 作为产物：
  描述：

  二硫化碳 、 2-[4-(hydrazinecarbonyl)phenylamino]benzoic acid hydrazide 在 potassium hydroxide 作用下， 以 乙醇 为溶剂， 以81%的产率得到5-{2-[4-(5-mercapto-1,3,4-oxadiazol-2-yl)phenylamino]phenyl}-1,3,4-oxadiazole-2-thiol
  参考文献：
  名称：

  Synthesis and biological evaluation of novel 2,4′-bis substituted diphenylamines as anticancer agents and potential epidermal growth factor receptor tyrosine kinase inhibitors

  摘要：

  Four new series of 2,4'-bis diphenylamine hydrazones 14, 2,4'-bis aminothiadiazole 16, 2,4'-bis mercaptotriazole 17-18 and 2,4'-bis mercapto-oxadiazole diphenylamine derivatives 19-20 were synthesized and evaluated for their ability to inhibit EGFR tyrosine kinase. Compound N-ethyl-5-{2-[4(5-(ethylamino)-1,3,4-thiadiazol-2-yl)- phenylaminolphenyl}-1,3,4-thiadiazol-2-amine 16a was the most active enzyme inhibitor (98% inhibition at 10 mu M). Moreover, all compounds that showed enzyme inhibition activity were tested in vitro on human breast carcinoma cell line (MCF-7) in which EGFR is highly expressed. The tested compounds exploited potent antitumor activity with IC50 values ranging 0.73-2.38 mu M. Molecular modeling and docking of the synthesized compounds into the active site of EGFR kinase domain showed good agreement with the obtained biological results. The present work represents a novel class of diphenylamine based derivatives with potent cytotoxicity and promising EGFR PTK inhibition activity. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.05.072

文献信息

• Synthesis and biological evaluation of novel 2,4′-bis substituted diphenylamines as anticancer agents and potential epidermal growth factor receptor tyrosine kinase inhibitors
  作者：Sahar Mahmoud Abou-Seri

  DOI：10.1016/j.ejmech.2010.05.072

  日期：2010.9

  Four new series of 2,4'-bis diphenylamine hydrazones 14, 2,4'-bis aminothiadiazole 16, 2,4'-bis mercaptotriazole 17-18 and 2,4'-bis mercapto-oxadiazole diphenylamine derivatives 19-20 were synthesized and evaluated for their ability to inhibit EGFR tyrosine kinase. Compound N-ethyl-5-2-[4(5-(ethylamino)-1,3,4-thiadiazol-2-yl)- phenylaminolphenyl}-1,3,4-thiadiazol-2-amine 16a was the most active enzyme inhibitor (98% inhibition at 10 mu M). Moreover, all compounds that showed enzyme inhibition activity were tested in vitro on human breast carcinoma cell line (MCF-7) in which EGFR is highly expressed. The tested compounds exploited potent antitumor activity with IC50 values ranging 0.73-2.38 mu M. Molecular modeling and docking of the synthesized compounds into the active site of EGFR kinase domain showed good agreement with the obtained biological results. The present work represents a novel class of diphenylamine based derivatives with potent cytotoxicity and promising EGFR PTK inhibition activity. (C) 2010 Elsevier Masson SAS. All rights reserved.