((15,35,55,75-tetra-tert-butyl-32,72-dimethoxy-1,3,5,7(1,3)-tetrabenzenacyclooctaphane-12,52-diyl)bis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate) | 1070867-06-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ((15,35,55,75-tetra-tert-butyl-32,72-dimethoxy-1,3,5,7(1,3)-tetrabenzenacyclooctaphane-12,52-diyl)bis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate)
• CAS: 1070867-06-9
• 化学式: C₆₄H₈₀O₁₀S₂
• 分子量: 1073.47
• InChiKey: ARNBAVRVGBLMLW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.76
• 重原子数：
  76.0
• 可旋转键数：
  14.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  123.66
• 氢给体数：
  0.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  (R,R)-2-[furfuryl-(2-hydroxy-2-phenylethyl)-amino]-1-phenylethanol 、 ((15,35,55,75-tetra-tert-butyl-32,72-dimethoxy-1,3,5,7(1,3)-tetrabenzenacyclooctaphane-12,52-diyl)bis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate) 以 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 反应 50.0h， 生成
  参考文献：
  名称：

  手性杯[4]氮杂卓氨基酸对氨基酸衍生物的对映体识别

  摘要：

  在这项研究中，已经报道了新的手性杯[4]氮杂row衍生物的合成。通过使用紫外可见光谱研究了手性受体的对映选择性。所有手性杯[4]芳烃衍生物对苯丙氨酸（Phe-OMe·HCl）和丙氨酸甲酯盐酸盐（Ala-OMe·HCl）的对映异构体均表现出一定的手性识别能力。作为手性受体，糠基武装杯[4]氮杂冠醚7具有用于α氨基酸酯盐酸盐最好对映体分辨力（高达ķ大号/ ķ d = 2.08，ΔΔ ģ 0 = -1.82千焦耳摩尔-1）在CHCl 3中。还从热力学的角度讨论了对映体的对映体识别能力。

  DOI：

  10.1016/j.tet.2009.01.087
• 作为产物：
  描述：

  1,3-二甲氧基-4-叔丁基杯芳烃 在 吡啶 、 lithium aluminium tetrahydride 、 potassium carbonate 作用下， 以 乙醚 、 丙酮 为溶剂， 生成 ((15,35,55,75-tetra-tert-butyl-32,72-dimethoxy-1,3,5,7(1,3)-tetrabenzenacyclooctaphane-12,52-diyl)bis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate)
  参考文献：
  名称：

  Synthesis and application of an efficient calix[4]arene-based anion receptor bearing imidazole groups for Cr(VI) anionic species

  摘要：

  We synthesized the new calix[4]arene amines bearing two and four imidazole or tert-butylamine moieties (9a,b/10a,b) by the reaction of di-or tetra-tosylated calix[4]arene derivatives (7 and 8, respectively) with 1-(3-aminopropyl)imidazole and/or tert-butylamine, respectively. After the characterization of 9a,b/10a,b their extraction abilities toward Cr(VI) anionic species (CAS) was evaluated and compared by the liquid liquid extraction method. The extraction results revealed that calix[4]arene amine having four imidazole groups (10a) was an efficient anion receptor for CAS. Moreover, the extraction of CAS by 10a in the presence of other anions such as Cl-, NO3-, and PO43- showed that 10a could be a selective anion receptor for CAS in the presence of those anions. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.03.103

文献信息

• Synthesis of new chiral calix[4]azacrowns for enantiomeric recognition of carboxylic acids
  作者：Havva Nur Demirtas、Selahattin Bozkurt、Mustafa Durmaz、Mustafa Yilmaz、Abdulkadir Sirit

  DOI：10.1016/j.tetasy.2008.08.015

  日期：2008.9

  Two novel chiral calix[4]azacrown ethers 4 and 5 bearing a furfuryl group on the nitrogen atom were developed by the reaction of dibromo- or ditosyl derivatives of p-tert-butylcalix[4]arenes 2 and 3 with a chiral diol, 1. The enantioselective recognition of these receptors towards the enantiomers of racemic carboxylic acids has been studied by H-1 NMR spectroscopy. The molar ratio and the association constants of the chiral compounds 4 and 5 with each of the enantiomers of guest molecules were determined by using job plots and a nonlinear least-squares fitting method, respectively. The job plots indicate that both of the hosts form 1:1 instantaneous complexes with (R)- OF (S)-mandelic acid and (L)- or (D)-dibenzoyl-tartaric acid. The receptors exhibited different chiral recognition abilities towards the enantiomers of racemic guests. (C) 2008 Elsevier Ltd. All rights reserved.