Synthesis of Functionalized β-Lactams and Pyrrolidine-2,5-diones through a Metal-Free Sequential Ugi-4CR/Cyclization Reaction
摘要:
An efficient approach for the synthesis of functionalized beta-lactams and pyrrolidine-2,5-diones was achieved through a sequential Ugi-4CR/cyclization reaction. Diversity-oriented synthesis, good to high yields, easy workup, and short reaction times are advantages of this procedure.
顺序Ugi四组分反应(4-CR)/ C ?使用(二乙酰氧基碘)苯进行H活化以合成3-(二苯基亚甲基)-2,3-二氢-1H-吲哚-2-酮
摘要:
一个顺序的Ugi四组分反应(4-CR)/ C 报道ħ激活使用(二乙酰氧基碘)苯。该过程是芳香醛,苯胺衍生物,异氰化物,苯丙酸(3-苯丙-2-炔酸)和(二乙酰氧基碘)苯的五组分反应,用于合成3-(二苯甲叉基)-2,3-二氢‐1 H‐吲哚‐2‐1。该方法具有许多优点,例如产率高,形成键的效率高,选择性高以及反应时间短。
An efficient method for the stereoselective synthesis of 3-(diarylmethylene)-2-oxindoles and 3-(arylmethylene)-2-oxindoles via carbopalladation is described. In this approach. an Ugi-4-component reaction (4-CR) adduct was used as the starting material. A one-pot sequence involving intermolecular carbopalladation C-H activation/C-C bond formation efficiently afforded the oxindole derivatives. (C) 2011 Elsevier Ltd. All rights reserved.