2-<3-Hydroxy-propyl>-benzotriazol | 69218-38-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并三唑类
• 英文名称: 2-<3-Hydroxy-propyl>-benzotriazol
• 英文别名: 3-benzotriazol-2-yl-propan-1-ol；3-(Benzotriazol-2-yl)propan-1-ol
• CAS: 69218-38-8
• 化学式: C₉H₁₁N₃O
• 分子量: 177.206
• InChiKey: AOKCBOTXTQLKJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  50.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-<3-Hydroxy-propyl>-benzotriazol 在 三乙胺 作用下， 以 苯 为溶剂， 反应 144.0h， 生成 2-{3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-propyl}-2H-benzotriazole
  参考文献：
  名称：

  Synthesis and pharmacological evaluation of aryl/heteroaryl piperazinyl alkyl benzotriazoles as ligands for some serotonin and dopamine receptor subtypes

  摘要：

  Thirteen [(aryl/heteroaryl-piperazinyl)alkyl]benzotriazoles were prepared as potential trazodone- and buspirone-like drugs. The synthesized compounds displayed from moderate to good affinity to the serotonin 5-HT1A receptor and only modest or poor affinity to the dopamine D-2 receptor, similar to buspirone. The introduction of substituents on the benzotriazole ring did,not improve the affinity to the 5-HT1A receptor, compared to the previously described unsubstituted derivatives. In a general pharmacological screening, which concerned only three of these compounds so far (5, 7 and 13), several in vitro and in vivo activities were observed.The guinea pig ileum contractions, induced either electrically or by several agonists, were strongly inhibited; at higher concentrations also the spontaneous tone of the guinea pig trachea was reduced. Compound 13 exhibited good analgesic activity in mice in the formalin-induced algesia and in the writhing test. The same at 30 mg kg(-1) p.o. also displayed antihypertensive activity probably related to calcium channel blockade and adrenergic alpha(1) antagonism. In binding assays, 13 showed a IC50 = 580 nM for displacing [H-3]prazosin from alpha(1) receptor.Finally, compound 5 (and, to a minor extent, compound 13) protected mice against potassium cyanide induced hypoxia. (C) 2001 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(01)01033-3
• 作为产物：
  描述：

  T406石油添加剂 、 3-氯-1-丙醇 在 sodium hydroxide 作用下， 反应 1.5h， 生成 2-<3-Hydroxy-propyl>-benzotriazol 、 3-(1H-benzo[d][1,2,3]triazol-1-yl)propan-1-ol
  参考文献：
  名称：

  Synthesis and pharmacological evaluation of aryl/heteroaryl piperazinyl alkyl benzotriazoles as ligands for some serotonin and dopamine receptor subtypes

  摘要：

  Thirteen [(aryl/heteroaryl-piperazinyl)alkyl]benzotriazoles were prepared as potential trazodone- and buspirone-like drugs. The synthesized compounds displayed from moderate to good affinity to the serotonin 5-HT1A receptor and only modest or poor affinity to the dopamine D-2 receptor, similar to buspirone. The introduction of substituents on the benzotriazole ring did,not improve the affinity to the 5-HT1A receptor, compared to the previously described unsubstituted derivatives. In a general pharmacological screening, which concerned only three of these compounds so far (5, 7 and 13), several in vitro and in vivo activities were observed.The guinea pig ileum contractions, induced either electrically or by several agonists, were strongly inhibited; at higher concentrations also the spontaneous tone of the guinea pig trachea was reduced. Compound 13 exhibited good analgesic activity in mice in the formalin-induced algesia and in the writhing test. The same at 30 mg kg(-1) p.o. also displayed antihypertensive activity probably related to calcium channel blockade and adrenergic alpha(1) antagonism. In binding assays, 13 showed a IC50 = 580 nM for displacing [H-3]prazosin from alpha(1) receptor.Finally, compound 5 (and, to a minor extent, compound 13) protected mice against potassium cyanide induced hypoxia. (C) 2001 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(01)01033-3

文献信息

• Uv-resistant hot-melt contact adhesive, a method for producing the same and adhesive objects produced therefrom
  申请人：——

  公开号：US20040014863A1

  公开（公告）日：2004-01-22

  The invention relates to a hot-melt contact adhesive, containing at least one unsaturated polymer and a particulate inorganic compound which has an average particle diameter d50 of between 0.05 and 300 &mgr;m. The invention also relates to a method for producing the same and to the use of inorganic particulate compounds of this type for producing a hot-melt contact adhesive. In addition, The invention relates to adhesive objects which are produced using a hot-melt contact adhesive of this type.

  本发明涉及一种热熔接触粘合剂，其中至少含有一种不饱和聚合物和一种颗粒状无机化合物，其平均颗粒直径 d50 在 0.05 至 300 微米之间。本发明还涉及一种生产方法，以及使用这种类型的无机颗粒化合物生产热熔接触胶粘剂。此外，本发明还涉及使用此类热熔接触粘合剂生产的粘合物体。
• Synthesis and pharmacological evaluation of aryl/heteroaryl piperazinyl alkyl benzotriazoles as ligands for some serotonin and dopamine receptor subtypes
  作者：Alessandro Boido、Caterina Canu Boido、Fabio Sparatore

  DOI：10.1016/s0014-827x(01)01033-3

  日期：2001.4

  Thirteen [(aryl/heteroaryl-piperazinyl)alkyl]benzotriazoles were prepared as potential trazodone- and buspirone-like drugs. The synthesized compounds displayed from moderate to good affinity to the serotonin 5-HT1A receptor and only modest or poor affinity to the dopamine D-2 receptor, similar to buspirone. The introduction of substituents on the benzotriazole ring did,not improve the affinity to the 5-HT1A receptor, compared to the previously described unsubstituted derivatives. In a general pharmacological screening, which concerned only three of these compounds so far (5, 7 and 13), several in vitro and in vivo activities were observed.The guinea pig ileum contractions, induced either electrically or by several agonists, were strongly inhibited; at higher concentrations also the spontaneous tone of the guinea pig trachea was reduced. Compound 13 exhibited good analgesic activity in mice in the formalin-induced algesia and in the writhing test. The same at 30 mg kg(-1) p.o. also displayed antihypertensive activity probably related to calcium channel blockade and adrenergic alpha(1) antagonism. In binding assays, 13 showed a IC50 = 580 nM for displacing [H-3]prazosin from alpha(1) receptor.Finally, compound 5 (and, to a minor extent, compound 13) protected mice against potassium cyanide induced hypoxia. (C) 2001 Elsevier Science S.A. All rights reserved.