tetramethyl 1-phenylpyrrole-2,3,4,5-tetracarboxylate | 37802-39-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: tetramethyl 1-phenylpyrrole-2,3,4,5-tetracarboxylate
• 英文别名: 2,3,4,5-Tetracarbomethoxy-N-phenyl-pyrrol；Tetramethyl-1-phenylpyrrol-2,3,4,5-tetracarboxylat；1-phenyl-pyrrole-2,3,4,5-tetracarboxylic acid tetramethyl ester；1-Phenyl-pyrrol-2,3,4,5-tetracarbonsaeure-tetramethylester
• CAS: 37802-39-4
• 化学式: C₁₈H₁₇NO₈
• 分子量: 375.335
• InChiKey: NHWARBIPXKEQHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  27
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  110
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  tetramethyl 1-phenylpyrrole-2,3,4,5-tetracarboxylate 在 硫酸 、 硝酸 作用下， 生成 tetramethyl 1-(p-nitrophenyl)pyrrole-2,3,4,5-tetracarboxylate
  参考文献：
  名称：

  A New Route to 1-Aryl Pyrroles¹

  摘要：

  DOI：

  10.1021/ja01583a046
• 作为产物：
  描述：

  dimethyl anilinofumarate 在 lead(IV) acetate 、 硫酸 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 生成 tetramethyl 1-phenylpyrrole-2,3,4,5-tetracarboxylate
  参考文献：
  名称：

  Vernon, John M.; Carr, Richard M.; Sukari, Mohamed A., Journal of Chemical Research, Miniprint, 1982, # 5, p. 1310 - 1334

  摘要：

  DOI：

文献信息

• One-Pot Silver-Catalyzed and PIDA-Mediated Sequential Reactions: Synthesis of Polysubstituted Pyrroles Directly from Alkynoates and Amines
  作者：Weibing Liu、Huanfeng Jiang、Liangbin Huang

  DOI：10.1021/ol9026478

  日期：2010.1.15

  The addition/oxidative cyclization of alkynes with amines in the presence of AgBF4 catalyst and PIDA oxidant leads to polysubstituted pyrroles. The reaction corresponds to the construction of a pyrrole fragment, which also provides a new way to the formation of C-C bonds.
• Conventional and Microwave-Assisted Facile One-Pot Synthesis of N-Substituted Pyrrole-2,3,4,5-tetracarboxylates Under Neat Conditions
  作者：H. Valizadeh、M. M. Heravi、M. Amiri

  DOI：10.1080/00397910903531680

  日期：2010.11.16

  Highly substituted pyrroles 3a,f were prepared conveniently in a reaction of (dimethyl- and diethyl-)acethylenedicarboxylates 1a-b with N-(methyl- and aryl-) hydroxylamines 2a-d in the presence of NaHCO3 using both conventional heating and microwave irradiation. Excelent yields of the very pure products were isolated under solvent-free conditions both at classical as well as microwave heating.
• VERNON, J. M.;CARR, R. M.;SUKARI, M. A., J. CHEM. RES. MICROFICHE, 1982, N 5, 115
  作者：VERNON, J. M.、CARR, R. M.、SUKARI, M. A.

  DOI：——

  日期：——