3-[[3-[(3-Phenylmethoxyphenyl)methoxy]phenyl]methoxy]benzaldehyde | 670274-74-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-[[3-[(3-Phenylmethoxyphenyl)methoxy]phenyl]methoxy]benzaldehyde
• CAS: 670274-74-5
• 化学式: C₂₈H₂₄O₄
• 分子量: 424.496
• InChiKey: CITDXAYDAFRLLP-UHFFFAOYSA-N

物化性质

• 沸点：
  610.3±50.0 °C(Predicted)
• 密度：
  1.195±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  32
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-[[3-[(3-Phenylmethoxyphenyl)methoxy]phenyl]methoxy]benzaldehyde 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 生成 [3-[[3-[(3-Phenylmethoxyphenyl)methoxy]phenyl]methoxy]phenyl]methanol
  参考文献：
  名称：

  Synthesis of Ether Oligomers

  摘要：

  Hydroxyaromatic aldehydes and ketones were used as building blocks to prepare ether oligomers. An iterative two-step protocol involving Mitsunobu coupling and carbonyl reduction provided a protecting-group-free route with high yields. Activity screening of an 84-member library against proteases led to the discovery of micromolar inhibitors for trypsin, chymotrypsin, and subtilisin.

  DOI：

  10.1021/ol036300d
• 作为产物：
  描述：

  3-苄氧基苯甲醛 在 sodium tetrahydroborate 、 偶氮二甲酸二异丙酯 、 三苯基膦 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 3-[[3-[(3-Phenylmethoxyphenyl)methoxy]phenyl]methoxy]benzaldehyde
  参考文献：
  名称：

  Synthesis of Ether Oligomers

  摘要：

  Hydroxyaromatic aldehydes and ketones were used as building blocks to prepare ether oligomers. An iterative two-step protocol involving Mitsunobu coupling and carbonyl reduction provided a protecting-group-free route with high yields. Activity screening of an 84-member library against proteases led to the discovery of micromolar inhibitors for trypsin, chymotrypsin, and subtilisin.

  DOI：

  10.1021/ol036300d

文献信息

• Synthesis of Ether Oligomers
  作者：Olivier Renaudet、Jean-Louis Reymond

  DOI：10.1021/ol036300d

  日期：2004.2.1

  Hydroxyaromatic aldehydes and ketones were used as building blocks to prepare ether oligomers. An iterative two-step protocol involving Mitsunobu coupling and carbonyl reduction provided a protecting-group-free route with high yields. Activity screening of an 84-member library against proteases led to the discovery of micromolar inhibitors for trypsin, chymotrypsin, and subtilisin.