tert-butyl (2R,3S)-3-((tert-butyldimethylsilyl)oxy)-2-(1-(hydroxyimino)propyl)pyrrolidine-1-carboxylate | 945469-28-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: tert-butyl (2R,3S)-3-((tert-butyldimethylsilyl)oxy)-2-(1-(hydroxyimino)propyl)pyrrolidine-1-carboxylate
• CAS: 945469-28-3
• 化学式: C₁₈H₃₆N₂O₄Si
• 分子量: 372.58
• InChiKey: RHLNTECVBBXZDX-LSDHHAIUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.63
• 重原子数：
  25.0
• 可旋转键数：
  4.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  71.36
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  tert-butyl (2R,3S)-3-((tert-butyldimethylsilyl)oxy)-2-(1-(hydroxyimino)propyl)pyrrolidine-1-carboxylate 在 palladium on activated charcoal 、 tris(dibenzylideneacetone)dipalladium (0) 、 chiral ferrocenyl catalyst 、 镍 氢气 、 caesium carbonate 、 三氟乙酸 作用下， 以 甲醇 、 二氯甲烷 、 水 、 二甲基亚砜 、 甲苯 为溶剂， 20.0~100.0 ℃ 、551.59 kPa 条件下， 反应 51.0h， 生成
  参考文献：
  名称：

  Discovery of Potent and Muscle Selective Androgen Receptor Modulators through Scaffold Modifications

  摘要：

  A novel series of imidazolin-2-ones were designed and synthesized as highly potent, orally active and muscle selective androgen receptor modulators (SARMs), with most of the compounds exhibiting low nM in vitro potency in androgen receptor (AR) binding and functional assays. Once daily oral treatment with the lead compound 11a (AR K-i = 0.9 nM, EC50 = 1.8 nM) for 14 days induced muscle growth with an ED50 of 0.09 mg/kg, providing approximately 50-fold selectivity over prostate growth in an orchidectomized rat model. Pharmacokinetic studies in rats demonstrated that the lead compound 11a had oral bioavailability of 65% and a plasma half-life of 5.5 h. On the basis of their preclinical profiles, the SARMs in this series are expected to provide beneficial anabolic effects on muscle with minimal androgenic effects on prostate tissue.

  DOI：

  10.1021/jm070312d
• 作为产物：
  描述：

  tert-butyl (2S,3S)-3-[tert-butyl(dimethyl)silyl]oxy-2-propanoylpyrrolidine-1-carboxylate 在 sodium acetate 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以100%的产率得到tert-butyl (2R,3S)-3-((tert-butyldimethylsilyl)oxy)-2-(1-(hydroxyimino)propyl)pyrrolidine-1-carboxylate
  参考文献：
  名称：

  Discovery of Potent and Muscle Selective Androgen Receptor Modulators through Scaffold Modifications

  摘要：

  A novel series of imidazolin-2-ones were designed and synthesized as highly potent, orally active and muscle selective androgen receptor modulators (SARMs), with most of the compounds exhibiting low nM in vitro potency in androgen receptor (AR) binding and functional assays. Once daily oral treatment with the lead compound 11a (AR K-i = 0.9 nM, EC50 = 1.8 nM) for 14 days induced muscle growth with an ED50 of 0.09 mg/kg, providing approximately 50-fold selectivity over prostate growth in an orchidectomized rat model. Pharmacokinetic studies in rats demonstrated that the lead compound 11a had oral bioavailability of 65% and a plasma half-life of 5.5 h. On the basis of their preclinical profiles, the SARMs in this series are expected to provide beneficial anabolic effects on muscle with minimal androgenic effects on prostate tissue.

  DOI：

  10.1021/jm070312d