N-<4,6-Bis-(diethylamino)-1,3,5-triazin-2-yl>-p-nitro-anilin | 326914-05-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-<4,6-Bis-(diethylamino)-1,3,5-triazin-2-yl>-p-nitro-anilin
• 英文别名: N,N,N',N'-tetraethyl-N''-(4-nitro-phenyl)-[1,3,5]triazine-2,4,6-triamine；N,N,N',N'-Tetraethyl-N''-(4-nitro-phenyl)-[1,3,5]triazine-2,4,6-triamine；2-N,2-N,4-N,4-N-tetraethyl-6-N-(4-nitrophenyl)-1,3,5-triazine-2,4,6-triamine
• CAS: 326914-05-0
• 化学式: C₁₇H₂₅N₇O₂
• mdl: MFCD00580071
• 分子量: 359.431
• InChiKey: BTLPXFFYNJUWKE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  103
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  4,6-dichloro-N-(4-nitrophenyl)-1,3,5-triazin-2-amine 、 二乙胺 在 potassium carbonate 作用下， 以 四氢呋喃 为溶剂， 生成 N-<4,6-Bis-(diethylamino)-1,3,5-triazin-2-yl>-p-nitro-anilin
  参考文献：
  名称：

  Syntheses of 2,4,6-trisubstituted triazines as antimalarial agents

  摘要：

  A series of 2,4,6-trisubstituted-1,3,5-triazines (2a-s) were synthesized and evaluated for their in vitro antimalarial activity against P. falciparum. Out of the 19 compounds synthesized eight compounds showed MIC in the range of 1-2 mug/mL. These compounds are in vitro several times more active than cycloguanil. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.11.052

文献信息

• Syntheses of 2,4,6-trisubstituted triazines as antimalarial agents
  作者：Anu Agarwal、Kumkum Srivastava、S.K. Puri、Prem M.S. Chauhan

  DOI：10.1016/j.bmcl.2004.11.052

  日期：2005.2

  A series of 2,4,6-trisubstituted-1,3,5-triazines (2a-s) were synthesized and evaluated for their in vitro antimalarial activity against P. falciparum. Out of the 19 compounds synthesized eight compounds showed MIC in the range of 1-2 mug/mL. These compounds are in vitro several times more active than cycloguanil. (C) 2004 Elsevier Ltd. All rights reserved.